公开(公告)号：EP3101027A1

公开(公告)日：2016-12-07

申请号：EP13899076.7

申请日：2013-12-09

申请人： Olymvax Biopharmaceuticals Inc. ,  Third Military Medical University Of PLA

发明人： ZOU, Quanming ,  ZENG, Hao ,  FAN, Shaowen ,  LU, Lu ,  FENG, Qiang ,  ZHANG, Jinyong ,  JING, Haiming ,  DONG, Yandong ,  WU, Yi ,  CAI, Changzhi

IPC分类号： C07K14/31 ,  C07K1/36 ,  C07K16/12 ,  C12N15/31 ,  C12N15/70 ,  C12N1/21 ,  C12P21/02 ,  A61K39/085 ,  A61K39/40 ,  A61P31/04 ,  G01N33/569

CPC分类号： C07K14/31 ,  A61K39/085 ,  A61K39/40 ,  A61K2039/55505 ,  A61K2039/575 ,  C07K16/12 ,  C07K16/1271 ,  C07K2319/00 ,  C12N15/70 ,  G01N33/56938 ,  G01N2333/31 ,  G01N2469/20 ,  G01N2800/26

摘要： Provided is staphylococcus protein A expressed by a mutational Staphylococcus aureus and its coding sequence, as well as a vector, host bacteria, composition or kit which contains the coding sequence of the mutational protein. Also provided is the use of the mutational protein and the composition thereof in the preparation of vaccines, therapeutic antibodies, diagnostic kits and the like, and for the prevention, treatment and detection of infections by Staphylococcus aureus . Also provided are methods for producing, fermenting and purifying the mutational protein.

摘要翻译： 提供了由突变金黄色葡萄球菌及其编码序列表达的葡萄球菌蛋白A，以及含有突变蛋白的编码序列的载体，宿主细菌，组合物或试剂盒。 还提供了突变蛋白及其组合物在制备疫苗，治疗性抗体，诊断试剂盒等中的用途，以及用于预防，治疗和检测金黄色葡萄球菌感染的用途。 还提供了用于产生，发酵和纯化突变蛋白的方法。