公开(公告)号：EP2427193A1

公开(公告)日：2012-03-14

申请号：EP10772372.8

申请日：2010-05-03

申请人： Omeros Corporation

发明人： BERGMANN, John, E. ,  CUTSHALL, Neil, S. ,  DEMOPULOS, Gregory, A. ,  FLORIO, Vincent, A. ,  GAITANARIS, George ,  GRAY, Patrick ,  HOHMANN, John ,  ONRUST, Rene ,  ZENG, Hongkui

IPC分类号： A61K31/50 ,  A61K31/415 ,  A61K31/38

CPC分类号： A61K31/551 ,  A61K31/00 ,  A61K31/085 ,  A61K31/122 ,  A61K31/137 ,  A61K31/192 ,  A61K31/195 ,  A61K31/198 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4162 ,  A61K31/425 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/527 ,  A61K31/542 ,  A61K45/06 ,  C07D471/04 ,  A61K2300/00

摘要： A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.

公开(公告)号：EP3226857A2

公开(公告)日：2017-10-11

申请号：EP15865551.4

申请日：2015-11-30

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  FLORIO, Vincent, A.

IPC分类号： A61K31/407 ,  A61K31/138 ,  A61K9/08

CPC分类号： A61K31/407 ,  A61K9/0048 ,  A61K31/137 ,  A61K31/192 ,  A61K31/405 ,  A61K31/4174 ,  A61K2300/00

摘要： The present invention provides methods for inhibiting postoperative inflammatory conditions following ophthalmologic surgical procedures by administering intraocularly during an ophthalmologic surgical procedure a solution including a nonsteroidal anti-inflammatory agent and an alpha-1 adrenergic mydriatic agent, such as a liquid irrigation solution of ketorolac and phenylephrine.

摘要翻译： 本发明提供了用于在眼科手术操作后抑制术后炎性病症的方法，其在眼科手术过程中通过眼内施用包含非甾体抗炎剂和α-1肾上腺素能散瞳剂的溶液，例如酮咯酸和苯福林 。

公开(公告)号：EP2427193B1

公开(公告)日：2018-07-11

申请号：EP10772372.8

申请日：2010-05-03

申请人： Omeros Corporation

发明人： BERGMANN, John, E. ,  CUTSHALL, Neil, S. ,  DEMOPULOS, Gregory, A. ,  FLORIO, Vincent, A. ,  GAITANARIS, George ,  GRAY, Patrick ,  HOHMANN, John ,  ONRUST, Rene ,  ZENG, Hongkui

IPC分类号： A61K31/50 ,  A61K31/415 ,  A61K31/38 ,  A61P25/14 ,  A61K31/137 ,  A61K31/195 ,  A61K31/425 ,  A61K31/433 ,  A61K31/00 ,  A61K31/519 ,  A61K31/527 ,  A61K45/06 ,  C07D471/06 ,  A61K31/085 ,  A61K31/122 ,  C07D471/04

CPC分类号： A61K31/551 ,  A61K31/00 ,  A61K31/085 ,  A61K31/122 ,  A61K31/137 ,  A61K31/192 ,  A61K31/195 ,  A61K31/198 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4162 ,  A61K31/425 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/527 ,  A61K31/542 ,  A61K45/06 ,  C07D471/04 ,  A61K2300/00

摘要： A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.

公开(公告)号：EP2139475B1

公开(公告)日：2014-12-17

申请号：EP08744515.1

申请日：2008-03-27

申请人： Omeros Corporation

发明人： BERGMANN, John, E. ,  CUTSHALL, Neil, S. ,  DEMOPULOS, Gregory, A. ,  FLORIO, Vincent, A. ,  GAITANARIS, George ,  GRAY, Patrick ,  HOHMANN, John ,  ONRUST, Rene ,  ZENG, Hongkui

IPC分类号： A61K31/435 ,  A61K31/195 ,  A61K31/433 ,  A61K31/519 ,  A61K31/527

CPC分类号： A61K31/195 ,  A61K31/433 ,  A61K31/519 ,  A61K31/527

公开(公告)号：EP2139475A2

公开(公告)日：2010-01-06

申请号：EP08744515.1

申请日：2008-03-27

申请人： Omeros Corporation

发明人： BERGMANN, John, E. ,  CUTSHALL, Neil, S. ,  DEMOPULOS, Gregory, A. ,  FLORIO, Vincent, A. ,  GAITANARIS, George ,  GRAY, Patrick ,  HOHMANN, John ,  ONRUST, Rene ,  ZENG, Hongkui

IPC分类号： A61K31/435

CPC分类号： A61K31/195 ,  A61K31/433 ,  A61K31/519 ,  A61K31/527

摘要： A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.