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    WHSC1 AND WHSC1L1 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS
    1.
    发明公开
    WHSC1 AND WHSC1L1 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS 审中-公开
    WHSC1和WHSC1L1靶基因用于癌症治疗和诊断

    公开(公告)号：EP2531598A1

    公开(公告)日：2012-12-12

    申请号：EP11739560.8

    申请日：2011-02-02

    申请人： OncoTherapy Science, Inc.

    发明人： HAMAMOTO, Ryuji ,  NAKAMURA, Yusuke ,  TSUNODA, Takuya

    IPC分类号： C12N15/09 ,  A61K31/713 ,  A61P35/00 ,  C12Q1/68

    CPC分类号： C12N15/1137 ,  A61K31/713 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/53

    摘要： Objective methods for diagnosing a predisposition to developing cancer, for example, bladder cancer, breast cancer, cholangiocellular carcinoma, CML, esophageal cancer, HCC, NSCLC, SCLC, osteosarcoma, pancreatic cancer, prostate cancer, renal cell carcinoma, soft tissue tumor and lymphoma, are described herein. In one embodiment, the diagnostic method involves determining an expression level of a WHSC1 or WHSC1L1 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of WHSC1 or WHSC1L1 associated disease, such as a cancer, e.g., bladder cancer, breast cancer, cholangiocellular carcinoma, CML, esophageal cancer, HCC, NSCLC, SCLC, osteosarcoma, pancreatic cancer, prostate cancer, renal cell carcinoma, soft tissue tumor and lymphoma. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of WHSC1 or WHSC1L1 associated diseases. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions including them. Also, disclosed are methods of identifying substances for treating or/and preventing lung cancer, using as an index their effect on expression of a WHSC1 or WHSC1L1 gene, or a biological activity of a WHSC1 or WHSC1L1 polypeptide.

    PRMT1 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS
    4.
    发明公开
    PRMT1 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS 有权
    PRMT1用于癌症治疗和诊断的靶基因

    公开(公告)号：EP2329044A1

    公开(公告)日：2011-06-08

    申请号：EP09809533.4

    申请日：2009-08-25

    申请人： Oncotherapy Science, Inc.

    发明人： NAKAMURA, Yusuke ,  HAMAMOTO, Ryuji ,  TOGASHI, Akira

    IPC分类号： C12Q1/68 ,  C12N15/00

    CPC分类号： C12N15/1137 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Y201/01125 ,  G01N33/57407 ,  G01N33/57484 ,  G01N2500/10

    摘要： Objective methods for diagnosing a predisposition to developing cancer, particularly bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer, are described herein. In one embodiment, the diagnostic method involves determining an expression level of PRMT1 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRMT1 associated disease, such as a cancer, e.g. bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of PRMT1 associated diseases. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions comprising them.

    摘要翻译： 本文描述了用于诊断癌症发生倾向的客观方法，特别是膀胱癌，胃癌，结肠直肠癌，乳腺癌，食道癌，肺癌，淋巴瘤，胰腺癌和睾丸癌。 在一个实施方案中，诊断方法涉及确定PRMT1基因的表达水平。 本发明进一步提供了筛选可用于治疗PRMT1相关疾病例如癌症的治疗剂的方法。 膀胱癌，胃癌，结肠直肠癌，乳腺癌，食道癌，肺癌，淋巴瘤，胰腺癌和睾丸癌。 本发明还提供了抑制细胞生长和治疗或缓解PRMT1相关疾病症状的方法。 本发明的特征还在于产物，包括双链分子和编码它们的载体以及包含它们的组合物。