公开(公告)号：EP2057187B1

公开(公告)日：2016-12-28

申请号：EP07805938.3

申请日：2007-08-10

申请人： Oncotherapy Science, Inc.

发明人： NAKAMURA, Yusuke ,  KATAGIRI, Toyomasa ,  NAKATSURU, Shuichi

IPC分类号： C07K14/43

CPC分类号： C07K16/18 ,  A61K31/7088 ,  C07K14/47 ,  C07K14/4748 ,  C12N2310/14 ,  C12Q1/485 ,  G01N33/5011 ,  G01N33/5035 ,  G01N33/57415 ,  G01N2333/9121 ,  G01N2510/00

公开(公告)号：EP2362904B1

公开(公告)日：2016-11-16

申请号：EP09809506.0

申请日：2009-08-21

申请人： Oncotherapy Science, Inc.

发明人： NAKAMURA, Yusuke ,  KATAGIRI, Toyomasa ,  TOGASHI, Akira

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K14/82 ,  C07K19/00 ,  G01N33/574 ,  G01N33/50 ,  C12N15/113

CPC分类号： C07K14/82 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/10 ,  C12N15/113 ,  C12N2310/14 ,  G01N33/5011

公开(公告)号：EP2044123B1

公开(公告)日：2013-03-13

申请号：EP06783136.2

申请日：2006-08-24

申请人： Oncotherapy Science, Inc.

发明人： NAKAMURA, Yusuke ,  KATAGIRI, Toyomasa ,  NAKATSURU, Shuichi ,  ENDO, Keigo ,  KUHARA, Motoki ,  YAGI, Kasumi

IPC分类号： C07K16/30 ,  A61K39/395

CPC分类号： C07K16/30 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0041 ,  A61K49/0058 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/24 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57426 ,  G01N33/57446

公开(公告)号：EP2057187A2

公开(公告)日：2009-05-13

申请号：EP07805938.3

申请日：2007-08-10

申请人： Oncotherapy Science, Inc.

发明人： NAKAMURA, Yusuke ,  KATAGIRI, Toyomasa ,  NAKATSURU, Shuichi

IPC分类号： C07K14/43

CPC分类号： C07K16/18 ,  A61K31/7088 ,  C07K14/47 ,  C07K14/4748 ,  C12N2310/14 ,  C12Q1/485 ,  G01N33/5011 ,  G01N33/5035 ,  G01N33/57415 ,  G01N2333/9121 ,  G01N2510/00

摘要： The present application provides novel human genes A7322, whose expression is markedly elevated in breast cancer. The present application also provides human genes F3374 whose expression is markedly elevated in breast cancer. These genes and polypeptides encoded thereby can be used, for example, in the diagnosis of breast cancer, and as target molecules for developing drugs against breast cancer. The invention features methods of screening for modulators of the kinase activity of PBK/TOPK. The invention further provides methods of screening for agents to prevent or treat cancer, such as breast cancer.

公开(公告)号：EP1546410A2

公开(公告)日：2005-06-29

申请号：EP03799103.1

申请日：2003-09-12

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  KATAGIRI, Toyomasa

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Objective methods for detecting and diagnosing testicular seminoma (TS) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of TS -associated gene that discriminate between TS and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of TS, methods of treating TS and method of vaccinating a subject against TS.

公开(公告)号：EP2362904A1

公开(公告)日：2011-09-07

申请号：EP09809506.0

申请日：2009-08-21

申请人： Oncotherapy Science, Inc.

发明人： NAKAMURA, Yusuke ,  KATAGIRI, Toyomasa ,  TOGASHI, Akira

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K14/82 ,  C07K19/00

CPC分类号： C07K14/82 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/10 ,  C12N15/113 ,  C12N2310/14 ,  G01N33/5011

摘要： The present invention provides therapeutic agents and methods for treating cancer using the polypeptides composed of an amino acid sequence which includes a polypeptide fragment of DEPDC1. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine. Furthermore, the present invention provides methods of screening for therapeutic agents or compounds useful in inhibition of the DEPDC1/ZNF224 complex formation or the treatment of cancer. The present invention also provides siRNAs targeting the ZNF224 gene, which are suggested to be useful in the treatment of bladder cancer.

公开(公告)号：EP1856278A2

公开(公告)日：2007-11-21

申请号：EP06713825.5

申请日：2006-02-09

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  KATAGIRI, Toyomasa ,  NAKATSURU, Shuichi

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2500/00

摘要： Objective methods for detecting and diagnosing bladder cancer (BLC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BLC-associated gene that discriminates between BLC cells and normal cells. The present invention further provides means for predicting and preventing bladder cancer metastasis using BLC-associated genes having unique altered expression patterns in bladder cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of bladder cancer, methods of treating bladder cancer and method for vaccinating a subject against bladder cancer. In particular, the present application provides novel human genes C2093, B5860Ns and C6055s whose expression is markedly elevated in bladder cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of bladder cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of bladder cancer.

公开(公告)号：EP1556518A2

公开(公告)日：2005-07-27

申请号：EP03799104.9

申请日：2003-09-12

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  KATAGIRI, Toyomasa

IPC分类号： C12Q1/68 ,  C07K14/82

CPC分类号： G01N33/57438 ,  A61K38/00 ,  C07K14/47 ,  C07K14/82 ,  C12Q1/6837 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y02A90/26

摘要： Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.

公开(公告)号：EP1546411A2

公开(公告)日：2005-06-29

申请号：EP03799119.7

申请日：2003-09-22

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  KATAGIRI, Toyomasa ,  NAKAGAWA, Hidewaki ,  NAKATSURU, Shuichi

IPC分类号： C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of PRC -associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.

公开(公告)号：EP1546197A2

公开(公告)日：2005-06-29

申请号：EP03799120.5

申请日：2003-09-22

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  KATAGIRI, Toyomasa ,  NAKAGAWA, Hidewaki ,  NAKATSURU, Shuichi

IPC分类号： C07K14/47 ,  C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.