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公开(公告)号：EP1856278A2
公开(公告)日：2007-11-21
申请号：EP06713825.5
申请日：2006-02-09
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2500/00
摘要： Objective methods for detecting and diagnosing bladder cancer (BLC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BLC-associated gene that discriminates between BLC cells and normal cells. The present invention further provides means for predicting and preventing bladder cancer metastasis using BLC-associated genes having unique altered expression patterns in bladder cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of bladder cancer, methods of treating bladder cancer and method for vaccinating a subject against bladder cancer. In particular, the present application provides novel human genes C2093, B5860Ns and C6055s whose expression is markedly elevated in bladder cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of bladder cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of bladder cancer.
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2.发明公开
公开(公告)号：EP1789801A1
公开(公告)日：2007-05-30
申请号：EP05770406.6
申请日：2005-08-09
IPC分类号： G01N33/574
CPC分类号： G01N33/5011 , G01N33/5035 , G01N33/57419 , G01N2500/02
摘要： The present invention provides methods and kits for identifying inhibitors of the interaction between C20orf20 and p120 which find utility in the treatment and prevention of colon cancer. Also disclosed herein are compositions for treating or preventing colon cancer identified by the screening method of the present invention and methods of using same in the treatment and prevention of colon cancer.
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3.发明公开NON-SMALL CELL LUNG CANCER-RELATED GENE, ANLN, AND ITS INTERACTIONS WITH RHOA 有权GEN ANLN与非小细胞肺癌及其与RhoA的相互作用
公开(公告)号：EP1787122A1
公开(公告)日：2007-05-23
申请号：EP05770407.4
申请日：2005-08-09
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G01N33/574 , G01N2333/82 , G01N2500/02
摘要： The present invention provides compositions and methods for identifying compounds for treating cancer as well as methods for predicting a prognosis of cancer. In particular, the present invention provides methods and kits for identifying inhibitors of the interaction between ANLN and RhoA which find utility in the treatment and prevention of cancer, particularly lung cancers such as non-small cell lung cancer (NSCLC). Also disclosed herein are compositions for treating or preventing cancer identified by the screening method of the present invention and methods of using same in the treatment and prevention of cancer.
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公开(公告)号：EP1430152B1
公开(公告)日：2007-03-07
申请号：EP02765617.2
申请日：2002-09-25
发明人： NAKAMURA, Yusuke , FURUKAWA, Yoichi
IPC分类号： C12Q1/68
CPC分类号： C07K14/4748 , C12Q1/6809 , C12Q1/6886 , C12Q2600/158
摘要： The present application provides a novel human gene ZNFN3A1 whose expression is markedly elevated in a great majority of HCCs compared to corresponding non-cancerous liver tissues. The gene encodes a protein having a zinc finger domain as well as a SET domain and has been found to form a regulatory complex with RNA helicase and RNA polymerase.
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公开(公告)号：EP1556518A2
公开(公告)日：2005-07-27
申请号：EP03799104.9
申请日：2003-09-12
CPC分类号： G01N33/57438 , A61K38/00 , C07K14/47 , C07K14/82 , C12Q1/6837 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , Y02A90/26
摘要： Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.
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公开(公告)号：EP1551998A2
公开(公告)日：2005-07-13
申请号：EP03753941.8
申请日：2003-09-22
CPC分类号： G01N33/57423 , A61K31/7088 , C07K14/47 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , G01N2800/50
摘要： Disclosed are methods for detecting non-small cell lung cancer using differentially expressed genes. Furthermore, novel human genes whose expression is elevated in non-small cell lung cancer compared to no-cancerous tissues are provided. Also disclosed are methods of identifying compounds for treating and preventing non-small cell lung cancer.
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公开(公告)号：EP1546411A2
公开(公告)日：2005-06-29
申请号：EP03799119.7
申请日：2003-09-22
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of PRC -associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.
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公开(公告)号：EP1546197A2
公开(公告)日：2005-06-29
申请号：EP03799120.5
申请日：2003-09-22
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
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公开(公告)号：EP1537243A1
公开(公告)日：2005-06-08
申请号：EP03795220.7
申请日：2003-08-12
IPC分类号： C12Q1/68
CPC分类号： G01N33/689 , C12Q1/6883 , C12Q2600/158 , G01N2800/364
摘要： Disclosed are methods of detecting ovarian endometriosis using differentially expressed genes. Also disclosed are methods of screening compounds serving as agents for treating ovarian endometriosis, and methods of treating ovarian endometriosis and method or vaccinating a subject against ovarian endometriosis.
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公开(公告)号：EP1668156A2
公开(公告)日：2006-06-14
申请号：EP04773526.1
申请日：2004-09-24
CPC分类号： C12Q1/6886 , C07K14/4702 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/04
摘要： Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer.
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