公开(公告)号：EP1247526B1

公开(公告)日：2005-12-14

申请号：EP00900174.4

申请日：2000-01-11

申请人： Ophtecs Corporation

发明人： YONEDA, Toyoaki ,  NAKAYAMA, Yoshio ,  MIICHI, Hiroaki ,  SAITO, Fumio ,  NAKAMURA, Shigeru

IPC分类号： A61K33/10 ,  A61K9/08 ,  A61P27/02

CPC分类号： A61K47/26 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/19 ,  A61K31/662 ,  A61K33/06 ,  A61K33/10 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K2300/00

摘要： One-pack type perfusion liquid preparations which are excellent in the effect of protecting eye tissues and corneal endothelial cells during and after cataract operation, intraocular lens transplantation, glaucoma operation, vitreous body operation and penetrating keratoplasty, and have a high biological safety. These preparations comprise an aqueous solution containing at least one compound selected from among D-3-hydroxybutyric acid and salts thereof, a hydrogencarbonate and calcium glycerophosphate and remain stable as a preparation even under severe temperature conditions.

摘要翻译： 在白内障手术，人工晶状体移植，青光眼手术，玻璃体手术和穿透性角膜移植术期间和之后保护眼组织和角膜内皮细胞的效果优异并且具有高生物学安全性的单液型灌注液制剂。 这些制剂包含含有至少一种选自D-3-羟基丁酸及其盐，碳酸氢盐和甘油磷酸钙的化合物的水溶液，并且即使在苛刻的温度条件下也能保持稳定。

公开(公告)号：EP1247526A1

公开(公告)日：2002-10-09

申请号：EP00900174.4

申请日：2000-01-11

申请人： Ophtecs Corporation

发明人： YONEDA, Toyoaki ,  NAKAYAMA, Yoshio ,  MIICHI, Hiroaki ,  SAITO, Fumio ,  NAKAMURA, Shigeru

IPC分类号： A61K33/10 ,  A61K9/08 ,  A61P27/02

CPC分类号： A61K47/26 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/19 ,  A61K31/662 ,  A61K33/06 ,  A61K33/10 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K2300/00

摘要： A one-pack irrigating solution preparation for ocular surgery of cataract, intraocular lens implantation, glaucoma, vitrectomy or penetrating keratoplasty, which is excellent in the protection of ocular tissues and corneal endothelial cells during and after the surgery and has a high in a living body safety. This preparation comprises an aqueous solution containing at least one compound selected from the group consisting of D-3-hydroxybutyric acid and its salts, bicarbonates, and calcium glycerophosphate and is stable under severe temperature conditions.

摘要翻译： 一包液体灌注制剂包含至少一种D-3-羟基丁酸或其盐，碳酸氢盐和甘油磷酸钙的水溶液。 活动：眼科。 在将针头插入荷兰兔的角膜的试验中，将含有1.0mM磷酸甘油磷酸钙，25.0mM碳酸氢钠和20.0mM D-3-羟基丁酸钠的灌注溶液以10ml / min的速度插入120分钟显着（p为 小于0.05）眼睛组织损伤减轻。 行动机制：无给予。