公开(公告)号：EP3088892B1

公开(公告)日：2018-07-25

申请号：EP16174438.8

申请日：2013-01-18

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： KANALEY, James D. ,  DING, Zhong ,  HOSIMER, Philip C. ,  SCALICE, Edward R. ,  DANIELSON, Susan ,  TOMASSO, David A. ,  WARREN, Timothy C.

IPC分类号： G01N33/543 ,  B01L3/00

CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/086 ,  G01N1/28 ,  Y10T436/2575

摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner.

公开(公告)号：EP3088892A1

公开(公告)日：2016-11-02

申请号：EP16174438.8

申请日：2013-01-18

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： KANALEY, James D. ,  DING, Zhong ,  HOSIMER, Philip C. ,  SCALICE, Edward R. ,  DANIELSON, Susan ,  TOMASSO, David A. ,  WARREN, Timothy C.

IPC分类号： G01N33/543 ,  B01L3/00

CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/086 ,  G01N1/28 ,  Y10T436/2575

摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner.

摘要翻译： 测定装置包括：液体样品区; 试剂区下游并与含有试剂材料的样品区流体连通; 检测区，其与具有与其结合的捕获元件的试剂区流体连通; 以及与捕获区流体连通的吸收区，其具有接收从检测区流动的液体样品的能力。 样品接收区域，试剂区域，检测区域和芯吸区域限定了流体流动路径，并且流体流动路径的至少一部分具有基底和从基底基本垂直延伸的突起，其中突起具有高度 ，横截面和彼此之间的距离，其限定能够产生平行于衬底表面的毛细管流动的突起之间的空间。 此外，具有突起的流体流路包括改变流路方向的角部。 修改拐角部分中或周围的突出部分，以在角部与拐角之前基本相同的构造下维持样品流动通过流路的流动前端的构型。