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1.发明公开DNA VACCINE CONTAINING VEGF-SPECIFIC EPITOPE AND/OR ANGIOPOIETIN-2-SPECIFIC EPITOPE 审中-公开DNA-IMPFSTOFFHALTIGES VEGF-SPEZIFISCHES EPITOP UND / ODER ANGIOPOIETIN-2-SPEZIFISCHES EPITOP
公开(公告)号：EP2891497A1
公开(公告)日：2015-07-08
申请号：EP13832772.1
申请日：2013-08-28
申请人： Osaka University , AnGes MG, Inc.
CPC分类号： A61K39/0011 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N7/00 , C12N2730/10134 , C12N2730/10143
摘要： The present invention provides a therapeutic or prophylactic agent for cancer, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of VEGF and/or a specific epitope of angiopoietin-2, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
摘要翻译： 本发明提供了一种癌症治疗剂或预防剂，其含有编码嵌合乙型肝炎病毒核心抗原多肽的表达载体，其插入含有VEGF特异性表位的氨基酸序列和/或血管生成素-2的特异性表位，其中， 将包含特异性表位的氨基酸序列插入到乙型肝炎病毒核心抗原多肽的氨基酸残基80和81之间。
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公开(公告)号：EP3222289A1
公开(公告)日：2017-09-27
申请号：EP15861370.3
申请日：2015-11-20
CPC分类号： A61K39/292 , A61K39/0008 , A61K2039/53 , A61K2039/545 , A61K2039/70 , C12N7/00 , C12N2730/10134
摘要： The present invention provides a combination preparation for inducing a specific immune response to an antigenic peptide, which contains
(I) the antigenic peptide, and
(II) an expression vector encoding a chimeric hepatitis B virus core antigen polypeptide, into which the antigenic peptide has been inserted or added, wherein said antigenic peptide is inserted in a region of amino acid residues 74 - 87 or 130 - 138 of the hepatitis B virus core antigen polypeptide, or added to the N-terminal or C-terminal of the hepatitis B virus core antigen polypeptide, wherein
the antigenic peptide of (I) and the expression vector of (II) are substantially simultaneously administered to a subject.摘要翻译： 本发明提供了用于诱导针对抗原肽的特异性免疫应答的组合制剂，所述抗原肽包含（I）抗原肽和（II）编码嵌合乙型肝炎病毒核心抗原多肽的表达载体，所述抗原肽具有 被插入或添加，其中所述抗原肽被插入乙型肝炎病毒核心抗原多肽的氨基酸残基74-87或130-138的区域，或被添加到乙型肝炎病毒的N-末端或C-末端 （I）的抗原肽和（II）的表达载体基本上同时施用于受试者的核心抗原多肽。
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3.发明公开
公开(公告)号：EP2436688A1
公开(公告)日：2012-04-04
申请号：EP10780549.1
申请日：2010-05-25
申请人： AnGes MG, Inc.
发明人： GEMBA, Takefumi , TOMIOKA, Hideki , TAMURA, Nao , SATA, Ryoko , MAEDA, Akito , TENMA, Akiko , KANAMORI, Toshihide , SAITO, Yoshimi , KOMABA, Shintaro , MORISHITA, Ryuichi
摘要： A novel polypeptide which has an excellent angiogenesis-inducing activity and an excellent antibacterial activity, and a novel angiogenesis-inducing agent which contains the polypeptide as an effective ingredient or a novel agent for treating a wound(s) which contains the polypeptide as an effective ingredient are disclosed. The polypeptide of the present invention is a polypeptide whose amino acid sequence is shown in any one of SEQ ID NOs:1 to 6, 8 and 10. The angiogenesis-inducing agent which contains the polypeptide of the present invention as an effective ingredient is useful for the prevention, amelioration or treatment of a disease such as a bums, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliteran.
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4.发明公开NOVEL POLYPEPTIDE HAVING ANGIOGENESIS-INDUCING ACTIVITY AND ANTIBACTERIAL ACTIVITY, AND USE THEREOF FOR MEDICAL PURPOSES 有权具有血管生成诱导活性和抗细菌活性的新型多肽及其用于医疗目的的用途
公开(公告)号：EP2371840A9
公开(公告)日：2012-02-22
申请号：EP09829160.2
申请日：2009-11-27
申请人： AnGes MG, Inc.
发明人： GEMBA, Takefumi , TOMIOKA, Hideki , SATA, Ryoko , TAMURA, Nao , MAEDA, Akito , KANAMORI, Toshihide , SAITO, Yoshimi , KOMABA, Shintaro , MORISHITA, Ryuichi
IPC分类号： C07K7/08 , A61K38/00 , A61P9/00 , A61P9/10 , A61P17/00 , A61P17/02 , A61P31/04 , C07K14/435 , C07K14/515
CPC分类号： C07K14/001 , A61K38/00 , C07K14/515
摘要： Novel polypeptides which have an excellent angiogenesis-inducing activity and an excellent antibacterial activity and medical uses thereof are disclosed. The amino acid sequences of the novel polypeptides are shown in any one of SEQ ID NOs:1 to 6. These polypeptides have angiogenesis-inducing and antibacterial activities. Such polypeptides are useful for the prevention, amelioration or treatment of skin wounds caused by a cut wound, surgical wound, erosion, burn, decubitus,intractable wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease or arteriosclerosis obliteran, and for the prevention, amelioration or treatment of bacterial infection in such skin wounds, and the like.
摘要翻译： 公开了具有优异的血管生成诱导活性和优异的抗菌活性的新型多肽及其医学用途。 新多肽的氨基酸序列显示于SEQ ID NO：1至6中的任何一个中。这些多肽具有诱导血管发生和抗菌活性。 这样的多肽可用于预防，改善或治疗由切伤，手术伤口，侵蚀，烧伤，褥疮，顽固性伤口，皮肤溃疡，腿部溃疡，糖尿病性溃疡，闭塞性动脉疾病或闭塞性动脉硬化症引起的皮肤伤口， 在这种皮肤伤口中预防，改善或治疗细菌感染等。
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5.发明授权
公开(公告)号：EP2436688B1
公开(公告)日：2014-07-09
申请号：EP10780549.1
申请日：2010-05-25
申请人： AnGes MG, Inc.
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6.发明授权NOVEL POLYPEPTIDE HAVING ANGIOGENESIS-INDUCING ACTIVITY AND ANTIBACTERIAL ACTIVITY, AND USE THEREOF FOR MEDICAL PURPOSES 有权新的多肽血管生成INTRODUCTORY活动与抗菌活性和用于医疗目的
公开(公告)号：EP2371840B1
公开(公告)日：2014-04-16
申请号：EP09829160.2
申请日：2009-11-27
申请人： AnGes MG, Inc.
发明人： GEMBA, Takefumi , TOMIOKA, Hideki , SATA, Ryoko , TAMURA, Nao , MAEDA, Akito , KANAMORI, Toshihide , SAITO, Yoshimi , KOMABA, Shintaro , MORISHITA, Ryuichi
IPC分类号： C07K7/08 , A61K38/00 , A61P9/00 , A61P9/10 , A61P17/00 , A61P17/02 , A61P31/04 , C07K14/435 , C07K14/515
CPC分类号： C07K14/001 , A61K38/00 , C07K14/515
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公开(公告)号：EP2404932B1
公开(公告)日：2014-07-23
申请号：EP10748830.6
申请日：2010-03-05
申请人： AnGes MG, Inc.
发明人： GEMBA, Takefumi , TOMIOKA, Hideki , TAMURA, Nao , TENMA, Akiko
IPC分类号： C07K14/21 , C07K7/08 , A61K9/08 , A61K9/12 , A61K9/70 , A61K38/00 , A61L15/44 , A61P7/00 , A61P9/10 , A61P17/00 , A61P17/02 , A61P31/02 , A61L15/46
CPC分类号： A61L15/46 , A61K38/00 , A61L2300/25 , A61L2300/404 , C07K7/08 , C07K14/212
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公开(公告)号：EP2404932A1
公开(公告)日：2012-01-11
申请号：EP10748830.6
申请日：2010-03-05
申请人： AnGes MG, Inc.
发明人： GEMBA, Takefumi , TOMIOKA, Hideki , TAMURA, Nao , TENMA, Akiko
IPC分类号： C07K7/08 , A61K9/08 , A61K9/12 , A61K9/70 , A61K38/00 , A61L15/44 , A61P7/00 , A61P9/10 , A61P17/00 , A61P17/02 , A61P31/02 , A61P31/04 , C07K14/00
CPC分类号： A61L15/46 , A61K38/00 , A61L2300/25 , A61L2300/404 , C07K7/08 , C07K14/212
摘要： A novel polypeptide, and an antibacterial agent, antifungal agent and/or antiseptic containing as an effective ingredient the polypeptide are disclosed. The polypeptide of this invention has an amino acid sequence shown in SEQ ID NOs:1 to 12 and 13 to 31. This antibacterial agent, antifungal agent and/or antiseptic is useful for the prevention, amelioration or treatment of diseases such as burn, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliterans, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, skin abscess, necrotizing subcutaneous infection, staphylococcal scalded skin syndrome (SSSS), folliculitis, facial furuncle, suppurative hidradenitis, carbuncle, infectious paronychia, erythrasma and severe infection (sepsis).
摘要翻译： 公开了一种新颖的多肽，以及含有多肽的有效成分的抗菌剂，抗真菌剂和/或防腐剂。 本发明的多肽具有SEQ ID NO：1至12和13至31所示的氨基酸序列。该抗菌剂，抗真菌剂和/或防腐剂可用于预防，改善或治疗诸如烧伤，褥疮 ，伤口，皮肤溃疡，腿部溃疡，糖尿病性溃疡，闭塞性动脉疾病和闭塞性动脉硬化症，蜂窝织炎，急性淋巴管炎，淋巴结炎，丹毒，皮肤脓肿，坏死性皮下感染，葡萄球菌性烫伤皮肤综合征（SSSS），毛囊炎，面部le疮，化脓性头痛 ，carb疮，感染性甲沟炎，红斑狼疮和严重感染（败血症）。
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9.发明公开NOVEL POLYPEPTIDE HAVING ANGIOGENESIS-INDUCING ACTIVITY AND ANTIBACTERIAL ACTIVITY, AND USE THEREOF FOR MEDICAL PURPOSES 有权新的多肽血管生成INTRODUCTORY活动与抗菌活性和用于医疗目的
公开(公告)号：EP2371840A1
公开(公告)日：2011-10-05
申请号：EP09829160.2
申请日：2009-11-27
申请人： AnGes MG, Inc.
发明人： GEMBA, Takefumi , TOMIOKA, Hideki , SATA, Ryoko , TAMURA, Nao , MAEDA, Akito , KANAMORI, Toshihide , SAITO, Yoshimi , KOMABA, Shintaro , MORISHITA, Ryuichi
IPC分类号： C07K7/08 , A61K38/00 , A61P9/00 , A61P9/10 , A61P17/00 , A61P17/02 , A61P31/04 , C07K14/435 , C07K14/515
CPC分类号： C07K14/001 , A61K38/00 , C07K14/515
摘要： Novel polypeptides which have an excellent angiogenesis-inducing activity and an excellent antibacterial activity and medical uses thereof are disclosed. The amino acid sequences of the novel polypeptides are shown in any one of SEQ ID NOs:1 to 6. These polypeptides have angiogenesis-inducing and antibacterial activities. Such polypeptides are useful for the prevention, amelioration or treatment of skin wounds caused by a cut wound, surgical wound, erosion, bum, decubitus,intractable wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease or arteriosclerosis obliteran, and for the prevention, amelioration or treatment of bacterial infection in such skin wounds, and the like.
摘要翻译： 新颖多肽，其具有优异的血管生成诱导活性和优异的抗菌活性和医药用途它们的游离缺失光盘。 该新的多肽的氨基酸序列分别示于SEQ ID NO中的任一项：1至6。这些多肽具有血管生成诱导和抗菌活性。 搜索多肽是用于预防，改善或治疗由刀伤，手术创面，糜烂，烧伤，褥疮，顽固性伤口，皮肤溃疡，下肢溃疡，糖尿病性溃疡，闭塞性动脉疾病或动脉硬化obliteran引起皮肤伤口，以及用于 预防，改善或治疗细菌感染的寻求皮肤伤口，等等。
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