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44 条记录 (耗时 0.014 秒)

    Process for preparing 2-alpha-methyl-2-beta-(1,2,3-triazol-1-yl)methyl-penam-3-alpha-carboxylic acid derivatives
    4.
    发明公开
    Process for preparing 2-alpha-methyl-2-beta-(1,2,3-triazol-1-yl)methyl-penam-3-alpha-carboxylic acid derivatives 失效
    Verfahren zur Herstellung von 2-α-Methyl-2-β-（1,2,3-三唑-1-基）甲基扑灭-3-α-碳二烯酸酯。

    公开(公告)号：EP0331395A1

    公开(公告)日：1989-09-06

    申请号：EP89301926.5

    申请日：1989-02-27

    申请人： TAIHO PHARMACEUTICAL COMPANY LIMITED ,  OTSUKA KAGAKU KABUSHIKI KAISHA

    发明人： Torii, Sigeru ,  Tanaka, Hideo ,  Tanaka, Motoaki ,  Yamada, Shozo ,  Nakai, Akira

    IPC分类号： C07D499/00 ,  C07D499/44

    CPC分类号： C07D499/00 ,  Y02P20/55

    摘要： 2α-Methyl-2β-(1,2,3-triazol-1-yl)methylpenam-3α-­carboxylic acid derivatives are prepared by reacting a penicillanic acid sulfoxide derivative of the formula
    wherein R is a penicillin carboxyl protecting group, and R₁ is hydrogen or halogen, R₂ is hydrogen, lower alkyl or the like with a triazole derivative of the formula
    wherein R₃ and R₄ are hydrogen, trialkylsilyl, lower alkyl, lower alkoxy or the like and R₅ is hydrogen or silyl substituted with 3 groups selected from the class consisting of lower alkyl, benzyl and phenyl in a solvent.

    摘要翻译： 2α-甲基-2β-（1,2,3-三唑-1-基）甲基亚磺酸-3α-羧酸衍生物通过使式的青霉烷酸亚砜衍生物，其中R是青霉素羧基 R 1为氢或卤素，R 2为氢，低级烷基等与式CHEM的三唑衍生物反应，其中R 3和R 4为氢，三烷基甲硅烷基，低级烷基，低级烷氧基等，R 5为氢 或在溶剂中由选自低级烷基，苄基和苯基的3种基团取代的甲硅烷基。

    Process for preparing 2 beta-substituted-methylpenicillin derivatives
    5.
    发明公开
    Process for preparing 2 beta-substituted-methylpenicillin derivatives 失效
    Verfahren zur Herstellung von 2-beta-substitutionierten-Methyl-penicillinderivaten。

    公开(公告)号：EP0331394A1

    公开(公告)日：1989-09-06

    申请号：EP89301925.7

    申请日：1989-02-27

    申请人： TAIHO PHARMACEUTICAL COMPANY LIMITED ,  OTSUKA KAGAKU KABUSHIKI KAISHA

    发明人： Torii, Sigeru ,  Tanaka, Hideo ,  Tanaka, Motoaki ,  Yamada, Shozo ,  Nakai, Akira

    IPC分类号： C07D499/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D499/00 ,  Y02P20/55

    摘要： A process for preparing a 2β-substituted-­methylpenicillin compound of the formula
    wherein -N Y is an optionally substituted heterocyclic group containing 2 to 4 nitrogen atoms as the hetero atom in the ring structure, and R₁ is a penicillin carboxyl protecting group, the process comprising reacting an azetidinonedisulfide compound of the formula
    wherein R₁ is as defined above and R is a substituted or unsubstituted heterocyclic group with a nitrogen-­containing heterocyclic compound of the formula
    wherein
    is as defined above in the presence of a metal compound.

    摘要翻译： 一种制备式CHEM的2β-取代 - 甲基青霉素化合物的方法，其中-NY是含有2-4个氮原子的任选取代的杂环基，作为环结构中的杂原子，R1是青霉素羧基保护基 该方法包括使式的氮杂环丁二烯硫醚化合物（其中R 1如上定义）和R是取代或未取代的杂环基与式CHEM的含氮杂环化合物反应，其中CHEM>如上所定义 在金属化合物的存在下。 ñ

    Process for preparing 2beta-substituted-methyl-penicillin derivatives
    7.
    发明公开
    Process for preparing 2beta-substituted-methyl-penicillin derivatives 失效
    Verfahren zur Herstellung von 2-β-substitutedierten甲基青霉素衍生物。

    公开(公告)号：EP0273599A1

    公开(公告)日：1988-07-06

    申请号：EP87310582.9

    申请日：1987-12-01

    申请人： TAIHO PHARMACEUTICAL COMPANY LIMITED ,  Otsuka Kagaku Kabushiki Kaisha

    发明人： Torii, Sigeru ,  Tanaka, Hideo ,  Tanaka, Motoaki, ,  Yamada, Shozo, ,  Nakai, Akira, ,  Ohbayashi, Hisashi, ,  Ohno, Tomoyasu,

    IPC分类号： C07D499/00

    CPC分类号： C07D499/00 ,  Y02P20/55

    摘要： Disclosed is a process for preparing 2β-substituted-methylpenicillin derivative of the formula
    wherein R is H or carboxyl protecting group, R 1 is H or halo, R 2 is H, lower alkyl. lower alkoxy, halogen. azido, lower alkylthio, phthalimide or a group -NHR 3 (wherein R 3 is H or acyl), and -
    is an optionally substituted monocyclic or bicyclic heterocyclic group having 1 to 4 nitrogen atoms in the ring structure, the process comprising reacting a compound of the formula
    wherein X is Cl or Br, and R, R 1 and R 2 are as defined above with a heterocyclic compound of the formula

    wherein -
    is as defined above.

    摘要翻译： 公开了制备式CHEM的2β-取代 - 甲基青霉素衍生物的方法，其中R为H或羧基保护基，R 1为H或卤素，R 2为H，低级烷基，低级烷氧基，卤素，叠氮基，低级烷硫基 ，邻苯二甲酰亚胺或-NHR 3基团（其中R 3为H或酰基），和 - @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@ 式其中X是Cl或Br，并且R 1，R 2和R 2如上定义，与下式的杂环化合物H @@@（III）其中 - @@@@如上所定义。 米

    Process for preparing exo-methylenepenam compounds
    9.
    发明公开
    Process for preparing exo-methylenepenam compounds 失效
    Verfahren zur Herstellung von Exo-Methylenpenam-Derivaten

    公开(公告)号：EP1225176A2

    公开(公告)日：2002-07-24

    申请号：EP02004762.7

    申请日：1996-03-07

    申请人： OTSUKA KAGAKU KABUSHIKI KAISHA

    发明人： Torii, Sigeru ,  Tanaka, Hideo ,  Sasaoka, Michio, Otsuka Kagaku Kabushiki Kaisha ,  Kameyama, Yutaka, Otsuka Kagaku Kabushiki Kaisha

    IPC分类号： C07D499/00

    CPC分类号： C07D499/00 ,  C07D205/09

    摘要： The present invention provides a process for for preparing an exo-methylenepenam compound represented by the general formula (5) characterized in that a β -lactam halide compound represented by the general formula (2) is reduced with a metal having a standard oxidation-reduction potential of up to -0.3 (V/SCE) in an amount of at least one mole per mole of the halide compound and with a metal compound having a higher standard oxidation-reduction potential than the metal in an amount of 0.0001 to 10 moles per mole of the halide compound, or is subjected to an electroreduction process to obtain the exo-methylenepenam compound.

    摘要翻译： 本发明提供一种制备由通式（5）表示的外亚甲基培南化合物的方法，其特征在于用通常的式（2）表示的β-内酰胺卤化物用具有标准氧化还原的金属还原 相对于每摩尔卤化物为至少1摩尔的量的高达-0.3（V / SCE）的电位，并且具有比金属高的标准氧化还原电位的金属化合物的量为0.0001至10摩尔/ 摩尔的卤化物化合物，或进行电还原处理，得到外亚甲基对甲酚化合物。