公开(公告)号：EP2168440B1

公开(公告)日：2018-03-28

申请号：EP08777224.0

申请日：2008-06-13

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： TOMINAGA, Michiaki ,  TAKI, Takao ,  MATSUMOTO, Toshiaki ,  HANYA, Izumi ,  IMADA, Takuma ,  MATSUOKA, Kunihiko ,  KISHIMOTO, Takuya ,  UCHIYAMA, Yuko ,  TSUNEISHI, Hiromasa ,  TSUJI, Machiko ,  VALDES-GONZALEZ, Tania ,  TADANO, Kentaro ,  KAMEDA, Kyoko

IPC分类号： A23L33/105 ,  A23L11/00 ,  A23L27/00

CPC分类号： A23L11/09 ,  A21D2/368 ,  A23C9/1307 ,  A23C9/1315 ,  A23C9/1544 ,  A23C11/02 ,  A23C11/103 ,  A23C20/025 ,  A23F3/163 ,  A23F5/243 ,  A23L2/52 ,  A23L5/23 ,  A23L7/196 ,  A23L9/12 ,  A23L13/426 ,  A23L13/65 ,  A23L17/70 ,  A23L21/15 ,  A23L23/00 ,  A23L27/50 ,  A23L27/60 ,  A23L33/105 ,  A61K31/353 ,  A61K36/48

摘要： The present invention relates to an extract obtained by extracting useful components containing equol from an equol-containing fermented soybean hypocotyl, and to a method for producing the same. The present invention makes it possible to efficiently obtain useful components containing equol from the fermented soybean hypocotyl by subjecting an equol-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution as an extractant. The present invention reduces the content of saponin, which causes an unpleasant taste, by sequentially subjecting the equol-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution and ethanol, while efficiently extracting equol and glycitein.

公开(公告)号：EP0724004A1

公开(公告)日：1996-07-31

申请号：EP95925102.6

申请日：1995-07-12

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： TAKAICHI, Akihisa 172-3, Aza Nakajima ,  OKAMOTO, Toshihiko ,  MATSUMOTO, Toshiaki

IPC分类号： C09K15/02 ,  C09K15/04 ,  C09K15/08 ,  A23L2/00 ,  A23L2/40 ,  A23L3/34

CPC分类号： C09K15/34 ,  A23L2/395 ,  A23L2/40 ,  A23L2/44 ,  A23L3/3463 ,  A23L3/358 ,  A23L33/15 ,  A23V2002/00 ,  A61K9/0007 ,  A61K31/015 ,  A61K31/353 ,  A61K31/355 ,  C09K15/04 ,  Y10S514/962 ,  A23V2250/628 ,  A23V2250/044 ,  A23V2250/708 ,  A23V2250/211 ,  A23V2250/712 ,  A23V2250/2132 ,  A23V2250/5028 ,  A23V2250/6416 ,  A23V2250/056 ,  A23V2250/032 ,  A23V2250/1614 ,  A23V2250/642

摘要： This invention provides an antioxidant-containing effervescent composition comprising, as essential components, 0.05 to 15% by weight of an antioxidant-containing powder, 10 to 35% by weight of sodium hydrogencarbonate and/or sodium carbonate, 10 to 70% by weight of a neutralizing agent and 30 to 55% by weight of an excipient. The antioxidant-containing effervescent composition of the invention stably contains an antioxidant and is excellent in solubility.

摘要翻译： 本发明提供一种含抗氧化剂的泡腾组合物，其包含作为必要组分的0.05至15重量％的含抗氧化剂的粉末，10至35重量％的碳酸氢钠和/或碳酸钠，10至70重量％ 中和剂和30至55重量％的赋形剂。 本发明的含抗氧化剂的泡腾组合物稳定地含有抗氧化剂，溶解性优异。

公开(公告)号：EP2168440A1

公开(公告)日：2010-03-31

申请号：EP08777224.0

申请日：2008-06-13

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： TOMINAGA, Michiaki ,  TAKI, Takao ,  MATSUMOTO, Toshiaki ,  HANYA, Izumi ,  IMADA, Takuma ,  MATSUOKA, Kunihiko ,  KISHIMOTO, Takuya ,  UCHIYAMA, Yuko ,  TSUNEISHI, Hiromasa ,  TSUJI, Machiko ,  VALDES-GONZALEZ, Tania ,  TADANO, Kentaro ,  KAMEDA, Kyoko

IPC分类号： A23L1/20 ,  A23L1/00 ,  A23L1/30 ,  A61K31/353 ,  A61K35/74 ,  A61K36/48 ,  A61P19/10 ,  A61P35/00

CPC分类号： A23L1/3002 ,  A21D2/368 ,  A23C9/1307 ,  A23C9/1315 ,  A23C9/1544 ,  A23C11/02 ,  A23C11/103 ,  A23C20/025 ,  A23F3/163 ,  A23F5/243 ,  A23L2/52 ,  A23L5/23 ,  A23L7/196 ,  A23L9/12 ,  A23L11/09 ,  A23L13/426 ,  A23L13/65 ,  A23L17/70 ,  A23L21/15 ,  A23L23/00 ,  A23L27/50 ,  A23L27/60 ,  A23L33/105 ,  A61K31/353 ,  A61K36/48

摘要： The present invention relates to an extract obtained by extracting useful components containing equol from an equol-containing fermented soybean hypocotyl, and to a method for producing the same.
The present invention makes it possible to efficiently obtain useful components containing equol from the fermented soybean hypocotyl by subjecting an equol-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution as an extractant. The present invention reduces the content of saponin, which causes an unpleasant taste, by sequentially subjecting the equol-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution and ethanol, while efficiently extracting equol and glycitein.

摘要翻译： 本发明涉及从含雌马酚发酵大豆下胚轴中提取含雌马酚的有用成分而得到的提取物及其制造方法。 本发明通过使用乙醇水溶液作为提取剂对含雌马酚的发酵大豆胚轴进行提取，可以有效地从发酵大豆下胚轴中获得含有雌马酚的有用组分。 本发明通过使用乙醇水溶液和乙醇依次对含有雌马酚的发酵大豆下胚轴进行提取，同时有效地提取雌马酚和黄豆黄素，从而降低引起不愉快味道的皂角苷的含量。

公开(公告)号：EP0788791A1

公开(公告)日：1997-08-13

申请号：EP96927897.7

申请日：1996-08-23

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： TAKAICHI, Akihisa 172-3, Aza Nakajima Takashima ,  OKAMOTO, Toshihiko ,  MATSUMOTO, Toshiaki

IPC分类号： A61K9/46 ,  A61K47/10

CPC分类号： A61K9/0007

摘要： The present invention provides a low-pressure-tableted effervescent preparation which is satisfactory in tablet hardness and dissolution properties, the preparation comprising 10 to 35% by weight of sodium hydrogencarbonate and/or sodium carbonate, 10 to 70% by weight of a neutralizing agent and 0.02 to 40% by weight of at least one member selected from the group consisting of maltitol, sorbitol, maltose, trehalose, mannitol, lactitol and xylitol.

摘要翻译： 本发明提供了一种片剂硬度和溶解性能令人满意的低压平片泡腾制剂，其制备方法包括10至35重量％的碳酸氢钠和/或碳酸钠，10至70重量％的中和剂 和0.02〜40重量％的选自麦芽糖醇，山梨糖醇，麦芽糖，海藻糖，甘露糖醇，乳糖醇和木糖醇中的至少一种。