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1.发明授权N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS 有权N，N-二SUBSTIUIERTE健身3-氨基吡咯烷作为MONO胺回收抑制剂的
公开(公告)号：EP1881975B1
公开(公告)日：2014-01-08
申请号：EP06756356.9
申请日：2006-05-12
发明人： KURIMURA, Muneaki , TAIRA, Shinichi , TOMOYASU, Takahiro , ITO, Nobuaki , TAI, Kuninori , TAKEMURA, Noriaki , MATSUZAKI, Takayuki , MENJO, Yasuhiro , MIYAMURA, Shin , SAKURAI, Yohji , WATANABE, Akihito , SAKATA, Yasuyo , MASUMOTO, Takumi , AKAZAWA, Kohei , SUGINO, Harukiho , AMADA, Naoki , OHASHI, Satoshi , SHINOHARA, Tomoichi , SASAKI, Hirofumi , MORITA, Chisako , YAMASHITA, Junko , NAKAJIMA, Satoko
IPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D207/14 , C07D405/12 , C07D407/12 , A61K31/497 , A61K31/4439 , A61K31/40 , A61P25/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D407/14
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
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公开(公告)号：EP2254873B1
公开(公告)日：2014-06-04
申请号：EP09713382.1
申请日：2009-02-20
发明人： OSHIMA, Kunio , OSHIYAMA, Takashi , TAIRA, Shinichi , MENJO, Yasuhiro , YAMABE, Hokuto , MATSUMURA, Shuuji , UEDA, Masataka , KOGA, Yasuo , TAI, Kuninori , NAKAYAMA, Sunao , ONOGAWA, Toshiyuki , TSUJIMAE, Kenji
IPC分类号： C07D243/12 , C07D401/12 , C07D401/14 , C07D491/04 , C07D405/14 , C07D417/14 , C07D409/14 , C07D495/04 , C07D471/04 , C07D513/04 , C07D413/14 , A61K31/551 , A61P9/06
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
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3.发明授权N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS 有权N，N-取代的3-氨基吡咯烷化合物可用作单胺再用抑制剂
公开(公告)号：EP1881975B8
公开(公告)日：2014-04-09
申请号：EP06756356.9
申请日：2006-05-12
发明人： KURIMURA, Muneaki , TAIRA, Shinichi , TOMOYASU, Takahiro , ITO, Nobuaki , TAI, Kuninori , TAKEMURA, Noriaki , MATSUZAKI, Takayuki , MENJO, Yasuhiro , MIYAMURA, Shin , SAKURAI, Yohji , WATANABE, Akihito , SAKATA, Yasuyo , MASUMOTO, Takumi , AKAZAWA, Kohei , SUGINO, Haruhiko , AMADA, Naoki , OHASHI, Satoshi , SHINOHARA, Tomoichi , SASAKI, Hirofumi , MORITA, Chisako , YAMASHITA, Junko , NAKAJIMA, Satoko
IPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D207/14 , C07D405/12 , C07D407/12 , A61K31/497 , A61K31/4439 , A61K31/40 , A61P25/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D407/14
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
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公开(公告)号：EP2254873A1
公开(公告)日：2010-12-01
申请号：EP09713382.1
申请日：2009-02-20
发明人： OSHIMA, Kunio , OSHIYAMA, Takashi , TAIRA, Shinichi , MENJO, Yasuhiro , YAMABE, Hokuto , MATSUMURA, Shuuji , UEDA, Masataka , KOGA, Yasuo , TAI, Kuninori , NAKAYAMA, Sunao , ONOGAWA, Toshiyuki , TSUJIMAE, Kenji
IPC分类号： C07D243/12 , C07D401/12 , C07D401/14 , C07D491/04 , C07D405/14 , C07D417/14 , C07D409/14 , C07D495/04 , C07D471/04 , C07D513/04 , C07D413/14 , A61K31/551 , A61P9/06
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention provides a novel benzodiazepine compound that blocks the I
Kur current or the Kv1.5 channel or the IKACH current (the GIRK1/4 channel) potently and more selectively than other K
+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R
1 , R
2 , R
3 , and R
4 are each independently hydrogen or lower alkyl; R
2 and R
3 may be linked to form lower alkylene; A
1 is lower alkylene optionally substituted with one or more hydroxy; and R
5 is group represented by wherein R
6 and R
7 are each independently hydrogen or organic group; X
A and X
B are each independently bond, lower alkylene, etc.-
公开(公告)号：EP2170831A1
公开(公告)日：2010-04-07
申请号：EP08765871.2
申请日：2008-06-26
发明人： KONDO, Kazumi , MENJO, Yasuhiro , TOMOYASU, Takahiro , MIYAMURA, Shin , TOMOHIRA, Yuso , MATSUDA, Takakuni , YAMADA, Keigo , KATO, Yusuke
IPC分类号： C07D223/16 , C07D405/12 , A61K31/55 , A61P7/00 , A61P9/00
CPC分类号： C07D223/16 , C07D405/12 , C07F9/5535 , Y02P20/55
摘要： The present invention provides a benzazepine compound that can maintain for a long period of time the blood level of tolvaptan enabling to provide the desired pharmaceutical effects. The benzazepine compound of the present invention is represented by general formula (1) wherein R 1 represents a -CO-(CH 2 ) n -COR 2 group (wherein n is an integer of 1 to 4, and R 2 is (2-1) a hydroxy group; (2-2) a lower alkoxy group optionally substituted with a hydroxy group, a lower alkanoyl group, a lower alkanoyloxy group, a lower alkoxycarbonyloxy group, a cycloalkyloxycarbonyloxy group, or 5-methyl-2-oxo-1,3-dioxol-4-yl; or (2-3) an amino group optionally substituted with a hydroxy-lower alkyl group), or the like.
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6.发明授权
公开(公告)号：EP2467364B9
公开(公告)日：2015-02-18
申请号：EP10751720.3
申请日：2010-08-20
发明人： OSHIMA, Kunio , MATSUMURA, Shuuji , YAMABE, Hokuto , ISONO, Naohiro , TAKEMURA, Noriaki , TAIRA, Shinichi , OSHIYAMA, Takashi , MENJO, Yasuhiro , NAGASE, Tsuyoshi , UEDA, Masataka , KOGA, Yasuo , NAKAYAMA, Sunao , TSUJIMAE, Kenji , ONOGAWA, Toshiyuki , TAI, Kuninori , ITOTANI, Motohiro
IPC分类号： C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/048 , C07D495/04 , C07D401/06 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/12 , C07D519/00 , C07D471/04 , C07D215/227
CPC分类号： C07D491/048 , C07D213/38 , C07D215/227 , C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
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公开(公告)号：EP1968990B1
公开(公告)日：2015-02-11
申请号：EP06843686.4
申请日：2006-12-22
发明人： KOMATSU, Makoto , GOTO, Fumitaka , MENJO, Yasuhiro , YAMADA, Keigo , MATSUDA, Takakuni , KATO, Yusuke
IPC分类号： C07F9/553 , A61K31/675
CPC分类号： C07F9/5535 , Y02P20/55
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8.发明授权
公开(公告)号：EP2467364B1
公开(公告)日：2014-04-16
申请号：EP10751720.3
申请日：2010-08-20
发明人： OSHIMA, Kunio , MATSUMURA, Shuuji , YAMABE, Hokuto , ISONO, Naohiro , TAKEMURA, Noriaki , TAIRA, Shinichi , OSHIYAMA, Takashi , MENJO, Yasuhiro , NAGASE, Tsuyoshi , UEDA, Masataka , KOGA, Yasuo , NAKAYAMA, Sunao , TSUJIMAE, Kenji , ONOGAWA, Toshiyuki , TAI, Kuninori , ITOTANI, Motohiro
IPC分类号： C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/048 , C07D495/04 , C07D401/06 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/12 , C07D519/00 , C07D471/04 , C07D215/227
CPC分类号： C07D491/048 , C07D213/38 , C07D215/227 , C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
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9.发明公开N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS 有权N，N-二SUBSTIUIERTE健身3-氨基吡咯烷作为MONO胺回收抑制剂的
公开(公告)号：EP1881975A1
公开(公告)日：2008-01-30
申请号：EP06756356.9
申请日：2006-05-12
发明人： KURIMURA, Muneaki , TAIRA, Shinichi , TOMOYASU, Takahiro , ITO, Nobuaki , TAI, Kuninori , TAKEMURA, Noriaki , MATSUZAKI, Takayuki , MENJO, Yasuhiro , MIYAMURA, Shin , SAKURAI, Yohji , WATANABE, Akihito , SAKATA, Yasuyo , MASUMOTO, Takumi , AKAZAWA, Kohei , SUGINO, Harukiho , AMADA, Naoki , OHASHI, Satoshi , SHINOHARA, Tomoichi , SASAKI, Hirofumi , MORITA, Chisako , YAMASHITA, Junko , NAKAJIMA, Satoko
IPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D207/14 , C07D405/12 , C07D407/12 , A61K31/497 , A61K31/4439 , A61K31/40 , A61P25/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D407/14
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
摘要： The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.
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公开(公告)号：EP4347597A1
公开(公告)日：2024-04-10
申请号：EP22732679.0
申请日：2022-06-01
发明人： UEMATSU, Yukitaka , OKADA, Minoru , SAITO, Akihiro , TAKAHASHI, Akira , NAKAMURA, Yuichi , HANARI, Taiki , MENJO, Yasuhiro , YAMAUCHI, Takahito , YAMAGUCHI, Atsushi , YUKI, Yohei , WATANABE, Kenji , MATSUDA, Satoshi
IPC分类号： C07D487/04 , A61P17/00 , A61P37/00 , A61K31/519
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