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1.发明公开
公开(公告)号：EP2467364A2
公开(公告)日：2012-06-27
申请号：EP10751720.3
申请日：2010-08-20
发明人： OSHIMA, Kunio , MATSUMURA, Shuuji , YAMABE, Hokuto , ISONO, Naohiro , TAKEMURA, Noriaki , TAIRA, Shinichi , OSHIYAMA, Takashi , MENJO, Yasuhiro , NAGASE, Tsuyoshi , UEDA, Masataka , KOGA, Yasuo , NAKAYAMA, Sunao , TSUJIMAE, Kenji , ONOGAWA, Toshiyuki , TAI, Kuninori , ITOTANI, Motohiro
IPC分类号： C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/048 , C07D495/04 , C07D401/06 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/12 , C07D519/00 , C07D471/04 , C07D215/227
CPC分类号： C07D491/048 , C07D213/38 , C07D215/227 , C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
摘要： The present invention provides a novel diazepine compound that blocks the I
Kur current or the Kv1.5 channel potently and more selectively than other K
+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R
1 , R
2 , R
3 , and R
4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R
2 and R
3 may be linked to form lower alkylene; A
1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y
1 and Y
2 are each independently -N= or -CH=; and R
5 is group represented by (2) wherein R
6 and R
7 are each independently hydrogen or organic group; R
6 and R
7 may be linked to form a ring together with the neighboring group -X
A -N-X
B -; X
A and X
B are each independently a bond, lower alkylene, etc.-
2.发明授权PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS 有权PIPERAZINSUBSTITUIERTE苯并精神疾病的治疗
公开(公告)号：EP1869025B1
公开(公告)日：2011-01-26
申请号：EP06732069.7
申请日：2006-04-12
发明人： YAMASHITA, Hiroshi, , MATSUBARA, Jun , OSHIMA, Kunio , KURODA, Hideaki , ITO, Nobuaki , MIYAMURA, Shin , SHIMIZU, Satoshi , TANAKA, Tatsuyoshi , TAKAHASHI, Haruka
IPC分类号： C07D409/12
CPC分类号： A61K31/496 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
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公开(公告)号：EP2254873A1
公开(公告)日：2010-12-01
申请号：EP09713382.1
申请日：2009-02-20
发明人： OSHIMA, Kunio , OSHIYAMA, Takashi , TAIRA, Shinichi , MENJO, Yasuhiro , YAMABE, Hokuto , MATSUMURA, Shuuji , UEDA, Masataka , KOGA, Yasuo , TAI, Kuninori , NAKAYAMA, Sunao , ONOGAWA, Toshiyuki , TSUJIMAE, Kenji
IPC分类号： C07D243/12 , C07D401/12 , C07D401/14 , C07D491/04 , C07D405/14 , C07D417/14 , C07D409/14 , C07D495/04 , C07D471/04 , C07D513/04 , C07D413/14 , A61K31/551 , A61P9/06
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention provides a novel benzodiazepine compound that blocks the I
Kur current or the Kv1.5 channel or the IKACH current (the GIRK1/4 channel) potently and more selectively than other K
+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R
1 , R
2 , R
3 , and R
4 are each independently hydrogen or lower alkyl; R
2 and R
3 may be linked to form lower alkylene; A
1 is lower alkylene optionally substituted with one or more hydroxy; and R
5 is group represented by wherein R
6 and R
7 are each independently hydrogen or organic group; X
A and X
B are each independently bond, lower alkylene, etc.-
公开(公告)号：EP2254873B1
公开(公告)日：2014-06-04
申请号：EP09713382.1
申请日：2009-02-20
发明人： OSHIMA, Kunio , OSHIYAMA, Takashi , TAIRA, Shinichi , MENJO, Yasuhiro , YAMABE, Hokuto , MATSUMURA, Shuuji , UEDA, Masataka , KOGA, Yasuo , TAI, Kuninori , NAKAYAMA, Sunao , ONOGAWA, Toshiyuki , TSUJIMAE, Kenji
IPC分类号： C07D243/12 , C07D401/12 , C07D401/14 , C07D491/04 , C07D405/14 , C07D417/14 , C07D409/14 , C07D495/04 , C07D471/04 , C07D513/04 , C07D413/14 , A61K31/551 , A61P9/06
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
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5.发明公开PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS 有权PIPERAZINSUBSTITUIERTE苯并精神疾病的治疗
公开(公告)号：EP1869025A1
公开(公告)日：2007-12-26
申请号：EP06732069.7
申请日：2006-04-12
发明人： YAMASHITA, Hiroshi, , MATSUBARA, Jun , OSHIMA, Kunio , KURODA, Hideaki , ITO, Nobuaki , MIYAMURA, Shin , SHIMIZU, Satoshi , TANAKA, Tatsuyoshi , OSHIRO, Yasuo , SHIMADA, Jun , MAEDA, Kenji , TADORI, Yoshihiro , AMADA, Naoki , AKAZAWA, Hitomi , YAMASHITA, Junko , MORI, Atsushi , UWAHODO, Yasufumi , MASUMOTO, Takumi , KIKUCHI, Tetsuro , HASHIMOTO, Kazuya , TAKAHASHI, Haruka
IPC分类号： C07D409/12
CPC分类号： A61K31/496 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
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6.发明授权PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS 有权PIPERAZINSUBSTITUIERTE苯并精神疾病的治疗
公开(公告)号：EP1869025B3
公开(公告)日：2016-08-31
申请号：EP06732069.7
申请日：2006-04-12
发明人： YAMASHITA, Hiroshi, , MATSUBARA, Jun , OSHIMA, Kunio , KURODA, Hideaki , ITO, Nobuaki , MIYAMURA, Shin , SHIMIZU, Satoshi , TANAKA, Tatsuyoshi , TAKAHASHI, Haruka
IPC分类号： C07D409/12
CPC分类号： A61K31/496 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
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7.发明授权
公开(公告)号：EP2467364B9
公开(公告)日：2015-02-18
申请号：EP10751720.3
申请日：2010-08-20
发明人： OSHIMA, Kunio , MATSUMURA, Shuuji , YAMABE, Hokuto , ISONO, Naohiro , TAKEMURA, Noriaki , TAIRA, Shinichi , OSHIYAMA, Takashi , MENJO, Yasuhiro , NAGASE, Tsuyoshi , UEDA, Masataka , KOGA, Yasuo , NAKAYAMA, Sunao , TSUJIMAE, Kenji , ONOGAWA, Toshiyuki , TAI, Kuninori , ITOTANI, Motohiro
IPC分类号： C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/048 , C07D495/04 , C07D401/06 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/12 , C07D519/00 , C07D471/04 , C07D215/227
CPC分类号： C07D491/048 , C07D213/38 , C07D215/227 , C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
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8.发明授权
公开(公告)号：EP2467364B1
公开(公告)日：2014-04-16
申请号：EP10751720.3
申请日：2010-08-20
发明人： OSHIMA, Kunio , MATSUMURA, Shuuji , YAMABE, Hokuto , ISONO, Naohiro , TAKEMURA, Noriaki , TAIRA, Shinichi , OSHIYAMA, Takashi , MENJO, Yasuhiro , NAGASE, Tsuyoshi , UEDA, Masataka , KOGA, Yasuo , NAKAYAMA, Sunao , TSUJIMAE, Kenji , ONOGAWA, Toshiyuki , TAI, Kuninori , ITOTANI, Motohiro
IPC分类号： C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/048 , C07D495/04 , C07D401/06 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/12 , C07D519/00 , C07D471/04 , C07D215/227
CPC分类号： C07D491/048 , C07D213/38 , C07D215/227 , C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
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