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公开(公告)号:EP3898997A1
公开(公告)日:2021-10-27
申请号:EP19898487.4
申请日:2019-12-20
发明人: BELL, John C. , HUH, Michael S. , TANG, Matthew Y. , PELIN, Adrian , BREITBACH, Caroline J. , BURGESS, Michael F. , BERNSTEIN, Steven H.
IPC分类号: C12N15/863 , A61K35/768 , A61P35/00 , C07K14/07 , C07K14/54 , C07K14/575 , C07K16/28 , C12N15/12 , C12N15/13 , C12N15/24 , C12N15/39 , C12N5/10 , C12N7/01
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公开(公告)号:EP4137578A1
公开(公告)日:2023-02-22
申请号:EP22175898.0
申请日:2019-01-04
发明人: BELL, John , LE BOEUF, Fabrice , HUH, Michael S. , TANG, Matthew Y. , KELLER, Brian Andrew , PELIN, Adrian
IPC分类号: C12N15/863 , A61K35/76 , A61K35/768 , A61P35/00 , C07K14/07 , C12N15/39 , C12N5/10 , C12N7/01
摘要: The disclosure relates to modified vaccinia virus vectors derived from the Copenhagen strain of vaccinia virus, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified Copenhagen-derived vaccinia virus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.
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公开(公告)号:EP3735467A1
公开(公告)日:2020-11-11
申请号:EP19736225.4
申请日:2019-01-04
发明人: BELL, John C. , LE BOEUF, Fabrice , HUH, Michael S. , TANG, Matthew Y. , KELLER, Brian Andrew , PELIN, Adrian
IPC分类号: C12N15/863 , A61K35/76 , A61K35/768 , A61P35/00 , C07K14/07 , C12N15/39 , C12N5/10 , C12N7/01
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公开(公告)号:EP3735466A1
公开(公告)日:2020-11-11
申请号:EP19736067.0
申请日:2019-01-04
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公开(公告)号:EP3898998A1
公开(公告)日:2021-10-27
申请号:EP19899693.6
申请日:2019-12-20
发明人: BELL, John C. , HUH, Michael S. , TANG, Matthew Y. , PELIN, Adrian , BREITBACH, Caroline J. , BURGESS, Michael F. , BERNSTEIN, Steven H.
IPC分类号: C12N15/863 , A61K35/768 , A61P35/00 , C07K14/065 , C07K16/28 , C12N15/12 , C12N15/13 , C12N15/19 , C12N15/24 , C12N15/39 , C12N15/52 , C12N5/10 , C12N7/01
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