公开(公告)号：EP3735466A1

公开(公告)日：2020-11-11

申请号：EP19736067.0

申请日：2019-01-04

申请人： Ottawa Hospital Research Institute ,  TURNSTONE BIOLOGICS CORP.

发明人： BELL, John C. ,  LE BOEUF, Fabrice ,  HUH, Michael S. ,  TANG, Matthew Y. ,  PELIN, Adrian ,  KELLER, Brian Andrew ,  BREITBACH, Caroline J. ,  BURGESS, Michael F. ,  BERNSTEIN, Steven H.

IPC分类号： C12N15/863 ,  C12N15/12 ,  C12N15/13 ,  C12N15/37 ,  C12N15/39 ,  C12N15/52 ,  C12N7/01

公开(公告)号：EP4137578A1

公开(公告)日：2023-02-22

申请号：EP22175898.0

申请日：2019-01-04

申请人： Ottawa Hospital Research Institute

发明人： BELL, John ,  LE BOEUF, Fabrice ,  HUH, Michael S. ,  TANG, Matthew Y. ,  KELLER, Brian Andrew ,  PELIN, Adrian

IPC分类号： C12N15/863 ,  A61K35/76 ,  A61K35/768 ,  A61P35/00 ,  C07K14/07 ,  C12N15/39 ,  C12N5/10 ,  C12N7/01

摘要： The disclosure relates to modified vaccinia virus vectors derived from the Copenhagen strain of vaccinia virus, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified Copenhagen-derived vaccinia virus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.

公开(公告)号：EP3735467A1

公开(公告)日：2020-11-11

申请号：EP19736225.4

申请日：2019-01-04

申请人： Ottawa Hospital Research Institute

发明人： BELL, John C. ,  LE BOEUF, Fabrice ,  HUH, Michael S. ,  TANG, Matthew Y. ,  KELLER, Brian Andrew ,  PELIN, Adrian

IPC分类号： C12N15/863 ,  A61K35/76 ,  A61K35/768 ,  A61P35/00 ,  C07K14/07 ,  C12N15/39 ,  C12N5/10 ,  C12N7/01