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公开(公告)号：EP1328509B1
公开(公告)日：2006-03-22
申请号：EP01987740.6
申请日：2001-10-17
IPC分类号： C07C271/16 , C07C309/65 , C07C309/72 , C07D303/36 , C07D263/20 , C07D413/10
CPC分类号： C07D263/20 , C07B2200/07 , C07C271/16 , C07D303/36 , C07D413/10
摘要： Methods of synthesizing pharmacologically useful oxazolidinones are disclosed, and, in particular, a method of manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a carbamate with a tert-butylcarbamoyl protected derivative of glycidylamine or 3-amino-1-halopropanol.
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2.发明公开4-OXO-4,7-DIHYDROFURO(2,3-B)PYRIDINE-5-CARBOXAMIDE ANTIVIRAL AGENTS 审中-公开抗病毒4-氧代-4,7-二氢呋喃并（2,3-B）吡啶-5-羧酰胺化合物
公开(公告)号：EP1465895A2
公开(公告)日：2004-10-13
申请号：EP03715931.6
申请日：2003-01-14
发明人： CUDAHY, Michele, M. , SHNUTE, Mark, E. , TANIS, Steven, P. , PERRAULT, William, R. , HERRINTON, Paul, Matthew , NAIR, Sajiv, K.
IPC分类号： C07D491/04 , A61K31/4355 , A61P31/12
CPC分类号： C07D491/04
摘要： The invention provides a compound of formula I: (I) Wherein G, R2, R3, and R4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection using such compounds or salts.
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公开(公告)号：EP0690848B1
公开(公告)日：1998-01-21
申请号：EP94912203.0
申请日：1994-03-15
IPC分类号： C07D213/74
CPC分类号： C07D213/74
摘要： The invention is a process to produce 3-alkylamino-2-piperazinylpyridines (III), where R3 is -CH2-CH3 or -CH(CH3)2, a process to purify them and their water clathrates. The 3-alkylamino-2-piperazinylpyridines (III) are used in the production of known compounds useful for treating individuals who are HIV positive.
摘要翻译： 本发明是生产3-烷基氨基-2-哌嗪基吡啶（III）的方法，其中R 3是-CH 2 -CH 3或-CH（CH 3）2，一种净化它们及其水包合物的方法。 3-烷基氨基-2-哌嗪基吡啶（III）用于生产用于治疗HIV阳性个体的已知化合物。
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公开(公告)号：EP1456208A1
公开(公告)日：2004-09-15
申请号：EP02789842.8
申请日：2002-12-19
IPC分类号： C07D471/06 , A61K31/498 , A61P31/22
CPC分类号： C07D471/06 , C07D241/44
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R?1 and R2¿ are as defined in the specification. The compounds are useful for the treatment of viral infections.
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公开(公告)号：EP0892792B1
公开(公告)日：2001-11-21
申请号：EP97915865.6
申请日：1997-03-28
发明人： PEARLMAN, Bruce, A. , PERRAULT, William, R. , BARBACHYN, Michael, R. , MANNINEN, Peter, R. , TOOPS, Dana, S. , HOUSER, David, J. , FLECK, Thomas, J.
IPC分类号： C07D263/24 , C07D263/20 , C07D413/10 , C07D487/04 , C07D413/04
CPC分类号： C07D487/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/20 , C07D263/24 , C07D413/04 , C07D413/10
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公开(公告)号：EP0892792A1
公开(公告)日：1999-01-27
申请号：EP97915865.0
申请日：1997-03-28
发明人： PEARLMAN, Bruce, A. , PERRAULT, William, R. , BARBACHYN, Michael, R. , MANNINEN, Peter, R. , TOOPS, Dana, S. , HOUSER, David, J. , FLECK, Thomas, J.
CPC分类号： C07D487/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/20 , C07D263/24 , C07D413/04 , C07D413/10
摘要： The present invention includes processes for producing 5-hydroxymethyl substituted oxazolidinone alcohols (III) from carbamates (IIA) or a trifluoroacetamide (IIB) using a dihydroxy compound (I) or glycidol (IV) starting material and for the transformation of the hydroxymethyl substituted oxazolidinone alcohols (III) to the corresponding amino compounds, 5-aminomethyl substituted oxazolidinone amines (VII) which are acylated to form commercially useful antibacterial 5-acylamidomethyl substituted oxazolidinone (VIII).
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公开(公告)号：EP1380121A2
公开(公告)日：2004-01-14
申请号：EP02725224.6
申请日：2002-04-15
IPC分类号： H04B7/00
CPC分类号： C07D263/20 , C07C233/18 , C07D413/10
摘要： Process for preparing a compoud of formula (I) which comprises reacting a N-aryl-O-alkylcarbamate of formula (II) with a compound of formula (III). W1 is Cl, Br, or -OS(O)2-R; W2 is H or -C(O)_R1. Starting materials (III) are partly new.
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公开(公告)号：EP1380121B1
公开(公告)日：2007-09-26
申请号：EP02725224.6
申请日：2002-04-15
IPC分类号： H04B7/00
CPC分类号： C07D263/20 , C07C233/18 , C07D413/10
摘要： Process for preparing a compoud of formula (I) which comprises reacting a N-aryl-O-alkylcarbamate of formula (II) with a compound of formula (III). W1 is Cl, Br, or -OS(O)2-R; W2 is H or -C(O)_R1. Starting materials (III) are partly new.
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公开(公告)号：EP1328509A1
公开(公告)日：2003-07-23
申请号：EP01987740.6
申请日：2001-10-17
IPC分类号： C07C271/16 , C07C309/65 , C07C309/72 , C07D303/36 , C07D263/20 , C07D413/10
CPC分类号： C07D263/20 , C07B2200/07 , C07C271/16 , C07D303/36 , C07D413/10
摘要： Methods of synthesizing pharmacologically useful oxazolidinones are disclosed, and, in particular, a method of manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a carbamate with a tert-butylcarbamoyl protected derivative of glycidylamine or 3-amino-1-halopropanol.
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