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公开(公告)号：EP1456208A1
公开(公告)日：2004-09-15
申请号：EP02789842.8
申请日：2002-12-19
IPC分类号： C07D471/06 , A61K31/498 , A61P31/22
CPC分类号： C07D471/06 , C07D241/44
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R?1 and R2¿ are as defined in the specification. The compounds are useful for the treatment of viral infections.
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2.发明公开
公开(公告)号：EP1467999A1
公开(公告)日：2004-10-20
申请号：EP03703799.1
申请日：2003-01-14
IPC分类号： C07D495/04 , A61K31/44 , A61P31/12 , A61P31/18
CPC分类号： C07D495/04
摘要： The invention provides a compound of formula (I) wherein G, R?2, and R3¿ have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection using such compounds or salts.
摘要翻译： 本发明提供了其中G，R 2和R 3具有本说明书中定义的任何值的式（I）化合物或其药学上可接受的盐，以及可用于制备该化合物或盐的方法和中间体 以及使用这些化合物或盐治疗疱疹病毒感染的方法。
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3.发明授权AMINOGUANIDINE CARBOXYLATES FOR THE TREATMENT OF NON-INSULIN-DEPENDENT DIABETES MELLITUS 失效羧基化氨基胍胰岛素依赖性糖尿病的治疗
公开(公告)号：EP0793646B1
公开(公告)日：2001-09-05
申请号：EP95939672.2
申请日：1995-11-13
发明人： LARSEN, Scott, D. , VAILLANCOURT, Valerie, A. , MAY, Paul, D. , TANIS, Steven, P. , TUCKER, John, A. , MEGLASSON, Martin, D. , SCHOSTAREZ, Heinrich, J.
IPC分类号： C07C281/16 , C07C281/18 , A61K31/195
CPC分类号： A61K31/195 , A61K31/198 , C07C281/16 , C07C281/18
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公开(公告)号：EP0991619A1
公开(公告)日：2000-04-12
申请号：EP98931521.3
申请日：1998-06-23
发明人： LOBL, Thomas J.-Coulter Pharmaceutical , RISHTON, Gil , TEEGARDEN, Bradley , POLINSKY, Alex , YAMAGISHI, Masafumi , TANIS, Steven, P. , FISHER, Jed, F. , THOMAS, Edward, W. , CHRUSCIEL, Robert, A.
IPC分类号： C07C233/63 , C07C233/87 , A61K31/16
CPC分类号： C07D213/81 , C07C229/46 , C07C233/60 , C07C233/63 , C07C233/83 , C07C233/87 , C07C235/40 , C07C235/64 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C255/29 , C07C255/46 , C07C259/08 , C07C271/22 , C07C271/28 , C07C275/26 , C07C275/42 , C07C311/21 , C07C311/64 , C07D207/16 , C07D209/20 , C07D213/64 , C07D213/82 , C07D217/26 , C07D233/64 , C07D295/185 , C07D295/192 , C07D307/68 , C07D333/24
摘要： The present invention relates to small molecules according to formula (I), which are potent inhibitors of α4β1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing α4β1 adhesion mediated conditions in a mammal such as a human.
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公开(公告)号：EP0991619B1
公开(公告)日：2003-09-10
申请号：EP98931521.3
申请日：1998-06-23
发明人： LOBL, Thomas J., Coulter Pharmaceutical , RISHTON, Gil , TEEGARDEN, Bradley , POLINSKY, Alex , YAMAGISHI, Masafumi , TANIS, Steven, P. , FISHER, Jed, F. , THOMAS, Edward, W. , CHRUSCIEL, Robert, A.
IPC分类号： C07C233/63 , C07C233/87 , A61K31/16
CPC分类号： C07D213/81 , C07C229/46 , C07C233/60 , C07C233/63 , C07C233/83 , C07C233/87 , C07C235/40 , C07C235/64 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C255/29 , C07C255/46 , C07C259/08 , C07C271/22 , C07C271/28 , C07C275/26 , C07C275/42 , C07C311/21 , C07C311/64 , C07D207/16 , C07D209/20 , C07D213/64 , C07D213/82 , C07D217/26 , C07D233/64 , C07D295/185 , C07D295/192 , C07D307/68 , C07D333/24
摘要： The present invention relates to small molecules according to formula (I), which are potent inhibitors of α4β1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing α4β1 adhesion mediated conditions in a mammal such as a human.
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公开(公告)号：EP1089989A1
公开(公告)日：2001-04-11
申请号：EP99930614.5
申请日：1999-06-23
发明人： BLINN, James, R. , CHRUSCIEL, Robert, A. , FISHER, Jed, F. , TANIS, Steven, P. , THOMAS, Edward, William , LOBL, Thomas, J. , TEEGARDEN, Bradley, R.
IPC分类号： C07D277/00
CPC分类号： C07D207/26 , C07D205/04 , C07D207/16 , C07D207/28 , C07D211/60 , C07D211/62 , C07D223/06 , C07D263/06 , C07D277/06 , C07D277/60 , C07D279/12 , C07D281/06 , C07D401/06 , C07D405/04 , C07D405/06 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10 , C07K5/06139
摘要： The present invention relates to compound of formula (I), that are potent inhibitors of α4β1 mediated adhesion to either VCAM or CS-1 and which could be useful for the treatment of inflammatory diseases. Specifically, the molecules of the present invention can be used for treating or preventing α4β1 adhesion mediated conditions in a mammal such as a human. This method may comprise administering to a mammal or a human patient an effective amount of the compound or composition as explained in the present specification.
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公开(公告)号：EP1472260A2
公开(公告)日：2004-11-03
申请号：EP03715930.8
申请日：2003-01-14
发明人： LARSEN, Scott, D. , MAY, Paul, D. , ROMINES, Karen , SCHNUTE, Mark, E. , TANIS, Steven, P. , NIEMAN, James, A. , ANDERSON, David, John , KIM, Euibong, J. , TURNER, Steven, Ronald
IPC分类号： C07D495/04 , C07D213/89 , C07D231/12 , C07D233/54 , C07D241/12 , C07D265/36 , C07D277/28 , C07D295/12 , C07C215/34 , C07C233/43 , C07C311/37 , C07C317/32 , A61K31/4365 , A61P31/22
CPC分类号： C07D495/04
摘要： The invention provides a compound of formula I: (F) wherein G, R2, R3, and R4 have any of the values defined in specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of preventing or treating a herpesvirus infection using such compounds or salts.
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8.发明公开4-OXO-4,7-DIHYDROFURO(2,3-B)PYRIDINE-5-CARBOXAMIDE ANTIVIRAL AGENTS 审中-公开抗病毒4-氧代-4,7-二氢呋喃并（2,3-B）吡啶-5-羧酰胺化合物
公开(公告)号：EP1465895A2
公开(公告)日：2004-10-13
申请号：EP03715931.6
申请日：2003-01-14
发明人： CUDAHY, Michele, M. , SHNUTE, Mark, E. , TANIS, Steven, P. , PERRAULT, William, R. , HERRINTON, Paul, Matthew , NAIR, Sajiv, K.
IPC分类号： C07D491/04 , A61K31/4355 , A61P31/12
CPC分类号： C07D491/04
摘要： The invention provides a compound of formula I: (I) Wherein G, R2, R3, and R4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection using such compounds or salts.
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9.发明公开COMPOUNDS AND METHODS FOR DIAGNOSING AND TREATING AMYLOID-RELATED CONDITIONS 审中-公开化合物和方法进行诊断和治疗淀粉样蛋白相关疾病
公开(公告)号：EP1318982A1
公开(公告)日：2003-06-18
申请号：EP01968919.9
申请日：2001-09-17
发明人： RAUB, Thomas, J. , TANIS, Steven, P. , BUHL, Allen, Edwin , CARTER, Donald, Bainbridge , BANDIERA, Tiziano , LANSEN, Jacqueline , PELLERANO, Cesare , SAVINI, Luisa
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： C07D215/38 , A61K31/47 , A61K45/06 , A61K51/0455 , A61K2300/00 , A61K31/00
摘要： The invention provides methods for diagnosing and treating amyloid-related conditions and compounds useful for the same. The invention provides for detecting, imaging, monitoring, diagnosing, and treating conditions characterized by the binding or aggregation of amyloid fibrils. More particularly, the invention relates to using quinolinehydrazone compounds for diagnosing and treating amyloidotic conditions and also as an antioxidant.
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公开(公告)号：EP1458719A1
公开(公告)日：2004-09-22
申请号：EP02786775.3
申请日：2002-12-19
发明人： STROHBACH, Joseph, W. , TANIS, Steven, P. , MOON, Malcolm, W. , NIEMAN, James, A. , BEAUCHAMP, Thomas, J. , NORTHUIS, Jill, M. , MCGHEE, William, D.
IPC分类号： C07D471/06 , A61K31/497 , A61P31/12 , C07D333/58 , C07D307/14 , C07D215/12 , C07D213/74 , C07D333/38 , C07D239/26 , C07D241/12 , C07D277/28 , C07D307/81 , C07D215/56
CPC分类号： C07D213/74 , C07D215/12 , C07D215/56 , C07D239/26 , C07D241/12 , C07D277/28 , C07D307/14 , C07D307/81 , C07D333/38 , C07D333/58 , C07D471/06
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R?1, R2 and R3¿ are as defined in the specification. The compounds are useful for the treatment of viral infections.
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