公开(公告)号：EP0671922A4

公开(公告)日：1996-08-21

申请号：EP94900605

申请日：1993-11-10

申请人： PURDUE RESEARCH FOUNDATION ,  METHODIST HOSPITAL INDIANA ,  KNAPP PETER M JR

发明人： BADYLAK STEPHEN F ,  HILES MICHAEL ,  WOYTIK SHERRY ,  DEMETER ROBERT J ,  KNAPP PETER M JR

IPC分类号： A61F2/02 ,  A61F2/28 ,  A61F2/30 ,  A61F2/38 ,  A61F2/44 ,  A61K35/38 ,  A61L27/00 ,  A61L27/36 ,  A61P3/00 ,  A61P43/00

CPC分类号： A61L27/3695 ,  A61F2/28 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2210/0004 ,  A61K35/38 ,  A61L27/3629 ,  A61L27/3645 ,  A61L27/365 ,  A61L27/367 ,  A61L27/3683 ,  A61L27/3691 ,  A61L2400/06

摘要： A fluidized, injectable tissue graft composition is described. The composition comprises comminuted intestinal submucosa or protease-digested intestinal submucosa. Methods for the preparation and use of injectable tissue graft compositions are described. In preferred embodiments the tissue graft material is prepared from the intestinal submucosa comprising the tunica submucosa, the muscularis mucosa and the stratum compactum of a segment of intestinal tissue of a warm-blooded vertebrate. Effective amounts of the fluidized graft compositions can be injected to promote repair tissue defects by inducing formation of endogenous tissues.

公开(公告)号：EP0655903A4

公开(公告)日：1995-11-02

申请号：EP94908154

申请日：1993-08-19

申请人： METHODIST HOSPITAL INDIANA ,  PURDUE RESEARCH FOUNDATION

发明人： DEMETER ROBERT J ,  BADYLAK STEPHEN F ,  FOSTER KIRK S ,  GEDDES LESLIE A

IPC分类号： A61J7/00 ,  A61J9/00 ,  A61J11/00 ,  A61J17/00

CPC分类号： A61J7/0046 ,  A61J7/0053 ,  A61J9/001 ,  A61J11/00 ,  A61J17/001 ,  A61J17/006

摘要： A device is provided for facilitating oral administration of unit dosages of liquid formulations, particularly to pediatric and geriatric patients. Sealed cartridges (28) containing unit doses of liquid nutrients or medications can be locked into the device and at the same time, breached so that the contained-liquid formulation (30) can flow from the cartridge (28) into a hollow nipple (14) for facile oral consumption. The liquid formulation-containing sealed cartridge (28) includes a container (72) having a side wall collapsible responsive to withdrawal of liquid from the hollow nipple.

摘要翻译： 提供了用于促进单位剂量液体制剂口服给药的装置，特别是儿科和老年患者。 含有单位剂量的液体营养剂或药物的密封盒（28）可以被锁定在装置中，并且同时被破坏，使得所包含的液体制剂（30）可以从药筒（28）流入空心接头（14 ）轻松口服消费。 含有液体制剂的密封盒（28）包括容器（72），该容器具有响应液体从中空乳头抽出而可收缩的侧壁。

公开(公告)号：EP0809691A4

公开(公告)日：2000-06-21

申请号：EP96905458

申请日：1996-02-09

申请人： PURDUE RESEARCH FOUNDATION ,  METHODIST HEALTH GROUP INC ,  LILLY CO ELI

发明人： BADYLAK STEPHEN F ,  BODER GEORGE ,  VOYTIK SHERRY ,  DEMETER ROBERT J ,  CRITSER JOHN K ,  LIU CHI

IPC分类号： C12M3/00 ,  C12N5/00 ,  C12N5/071 ,  C12N5/077 ,  A61K35/37 ,  A61K35/38

CPC分类号： C12N5/0655 ,  C12M23/34 ,  C12M25/02 ,  C12N5/0068 ,  C12N5/0676 ,  C12N5/0679 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2533/92 ,  Y10S623/915

摘要： A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing eukaryotic cells are described. Submucosal tissue used in accordance with the present invention supports the proliferation and differentiation of eukaryotic cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.

公开(公告)号：EP0820301A4

公开(公告)日：1998-07-08

申请号：EP96911561

申请日：1996-04-03

申请人： PURDUE RESEARCH FOUNDATION ,  METHODIST HEALTH GROUP INC

发明人： KNAPP PETER M JR ,  LINGEMAN JAMES E ,  DEMETER ROBERT J ,  BADYLAK STEPHEN F

IPC分类号： A61L27/00 ,  A61F2/04 ,  A61K35/38 ,  A61L27/36 ,  A61K38/35

CPC分类号： A61L27/3629 ,  A61K35/38 ,  A61L27/3679 ,  A61L2430/22

摘要： A method for surgical repair of a diseased or damaged bladder is described. Diseased or damaged bladder tissue is surgically replaced with submucosal tissue of a warm blooded vertebrate to promote regrowth of endogenous urinary bladder tissue.