公开(公告)号：EP2383285B1

公开(公告)日：2017-07-12

申请号：EP11157383.8

申请日：2007-02-05

申请人： Peptcell Limited

发明人： Caparrós-Wanderley, Wilson Romero ,  Stoloff, Gregory Alan

IPC分类号： C07K14/005 ,  A61K39/145 ,  A61K38/12

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2039/70 ,  C07K7/08 ,  C07K14/005 ,  C07K14/11 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16271

摘要： Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-6, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-6 that has the same length as the epitope: wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete influenza virus protein.

公开(公告)号：EP2392587A1

公开(公告)日：2011-12-07

申请号：EP11167363.8

申请日：2007-03-09

申请人： Peptcell Limited

发明人： Stoloff, Gregory Alan ,  Caparros-Wanderley, Wilson Romero

IPC分类号： C07K14/16 ,  A61K38/16 ,  A61P31/18

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/55544 ,  C07K14/005 ,  C07K2319/01 ,  C12N7/00 ,  C12N2740/16034 ,  C12N2740/16071 ,  C12N2740/16322 ,  C12N2740/16334

摘要： Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-4, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-4 that has the same length as the epitope:
SEQ ID 1 GDTWAGVEAIIRILQQLLFIHFRIGCQHSR
SEQ ID 2 KVGSLQYLALTALITPKKIKPPLPSVKKLTEDRWNKPQKT
SEQ ID 3 EPVPLQLPPLERLTLDCSEDCGTSGTQ
SEQ ID 4 YKGALDLSHFLKEKGGLEGLIYSQKRQDILDLWVYHTQGYFPD

wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete HIV virus protein.

摘要翻译： 提供了不超过100个氨基酸的多肽，所述多肽包含与SEQ ID 1-4中的任一个具有至少60％同源性的一个或多个序列，或者包含两个或更多个具有7个氨基酸或更多氨基酸的表位，每个表位具有 与任何SEQ ID 1-4具有相同的长度的表位的亚序列至少60％同源性：SEQ ID 1 GDTWAGVEAIIRILQQLLFIHFRIGCQHSR SEQ ID 2 KVGSLQYLALTALITPKKIKPPLPSVKKLTEDRWNKPQKT SEQ ID 3 EPVPLQLPPLERLTLDCSEDCGTSGTQ SEQ ID 4 YKGALDLSHFLKEKGGLEGLIYSQKRQDILDLWVYHTQGYFPD其中，所述多肽是免疫原性 表达主要组织相容性复合体（MHC）等位基因的脊椎动物，并且其中所述多肽不是完整的HIV病毒蛋白。

公开(公告)号：EP2383284B1

公开(公告)日：2016-08-24

申请号：EP11157382.0

申请日：2007-02-05

申请人： Peptcell Limited

发明人： Caparrós-Wanderley, Wilson Romero ,  Stoloff, Gregory Alan

IPC分类号： C07K14/11 ,  A61K39/145 ,  A61K39/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2039/70 ,  C07K7/08 ,  C07K14/005 ,  C07K14/11 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16271

摘要： Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-6, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-6 that has the same length as the epitope: wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete influenza virus protein.

公开(公告)号：EP2567706A2

公开(公告)日：2013-03-13

申请号：EP12177189.3

申请日：2008-09-05

申请人： Peptcell Limited

发明人： Stoloff, Gregory Alan ,  Capapros-Wanderley, Wilson Romero

IPC分类号： A61K38/01 ,  C07K14/435 ,  A61K39/005

CPC分类号： C07K14/43577 ,  A61K38/00 ,  A61K39/005 ,  A61K2039/53 ,  Y10S530/806 ,  Y10S530/855 ,  Y10S530/858

摘要： Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40kDA or less, and wherein the polypeptides are selected independently from:
the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or
from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.

摘要翻译： 提供了包含一种或多种多肽的多肽组合物，所述多肽在脊椎动物中是免疫原性的，使得它们引起脊椎动物产生能够识别来自节肢动物唾液蛋白组分的至少一种表位的免疫系统细胞，其中节肢动物唾液蛋白组分具有 40kDa或更低的质量，并且其中所述多肽独立地选自：SEQ ID 1-44的多肽序列或来自这些序列的子序列，具有7个氨基酸或更多的子序列; 或来自与一个或多个上述序列具有85％同源性或更高同源性且包含在一个或多个以下数据库中的多肽序列：GenBank，蛋白质数据库（PDB），SwissProt，蛋白质信息资源（PIR），蛋白质研究基金会 （PRF）或这些CDS翻译。

公开(公告)号：EP2567706A3

公开(公告)日：2013-06-12

申请号：EP12177189.3

申请日：2008-09-05

申请人： Peptcell Limited

发明人： Stoloff, Gregory Alan ,  Capapros-Wanderley, Wilson Romero

IPC分类号： A61K38/01 ,  C07K14/435 ,  A61K39/005

CPC分类号： C07K14/43577 ,  A61K38/00 ,  A61K39/005 ,  A61K2039/53 ,  Y10S530/806 ,  Y10S530/855 ,  Y10S530/858

摘要： Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40kDA or less, and wherein the polypeptides are selected independently from:
the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or
from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.

公开(公告)号：EP2783694B1

公开(公告)日：2018-02-28

申请号：EP14162925.3

申请日：2008-09-05

申请人： Peptcell Limited

发明人： Stoloff, Gregory Alan ,  Caparros-Wanderley, Wilson Romero

IPC分类号： A61K38/00 ,  A61K39/005 ,  C07K14/435 ,  A61K39/00

CPC分类号： C07K14/43577 ,  A61K38/00 ,  A61K39/005 ,  A61K2039/53 ,  Y10S530/806 ,  Y10S530/855 ,  Y10S530/858

摘要： Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40kDA or less, and wherein the polypeptides are selected independently from: the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.

公开(公告)号：EP2392587B1

公开(公告)日：2016-05-04

申请号：EP11167363.8

申请日：2007-03-09

申请人： Peptcell Limited

发明人： Stoloff, Gregory Alan ,  Caparrós-Wanderley, Wilson Romero

IPC分类号： C07K14/16 ,  A61K38/16 ,  A61P31/18

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/55544 ,  C07K14/005 ,  C07K2319/01 ,  C12N7/00 ,  C12N2740/16034 ,  C12N2740/16071 ,  C12N2740/16322 ,  C12N2740/16334

摘要： Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-4, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-4 that has the same length as the epitope: SEQ ID 1 GDTWAGVEAIIRILQQLLFIHFRIGCQHSR SEQ ID 2 KVGSLQYLALTALITPKKIKPPLPSVKKLTEDRWNKPQKT SEQ ID 3 EPVPLQLPPLERLTLDCSEDCGTSGTQ SEQ ID 4 YKGALDLSHFLKEKGGLEGLIYSQKRQDILDLWVYHTQGYFPD wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete HIV virus protein.

公开(公告)号：EP2783694A3

公开(公告)日：2015-01-07

申请号：EP14162925.3

申请日：2008-09-05

申请人： Peptcell Limited

发明人： Stoloff, Gregory Alan ,  Caparros-Wanderley, Wilson Romero

IPC分类号： A61K38/01 ,  C07K14/435 ,  A61K39/00 ,  A61K39/005

CPC分类号： C07K14/43577 ,  A61K38/00 ,  A61K39/005 ,  A61K2039/53 ,  Y10S530/806 ,  Y10S530/855 ,  Y10S530/858

摘要： Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40kDA or less, and wherein the polypeptides are selected independently from:
the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or
from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.

公开(公告)号：EP2783694A2

公开(公告)日：2014-10-01

申请号：EP14162925.3

申请日：2008-09-05

申请人： Peptcell Limited

发明人： Stoloff, Gregory Alan ,  Caparros-Wanderley, Wilson Romero

IPC分类号： A61K38/01 ,  C07K14/435 ,  A61K39/00 ,  A61K39/005

CPC分类号： C07K14/43577 ,  A61K38/00 ,  A61K39/005 ,  A61K2039/53 ,  Y10S530/806 ,  Y10S530/855 ,  Y10S530/858

摘要： Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40kDA or less, and wherein the polypeptides are selected independently from:
the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or
from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.

摘要翻译： 提供了一种多肽组合物，其包含一种或多种多肽，该多肽在脊椎动物中是免疫原性的，使得它们使脊椎动物产生能够识别节肢动物唾液蛋白质级分中的至少一个表位的免疫系统细胞，其中节肢动物唾液蛋白质级分具有 质量为40kDA或更小，并且其中所述多肽独立地选自：SEQ ID 1-44的多肽序列或来自这些序列的亚序列，所述亚序列具有7个氨基酸或更多个; 或来自与一个或多个上述序列具有85％同源性或更多的多肽序列，并且包含在一个或多个以下数据库中：GenBank，蛋白质数据库（PDB），SwissProt，蛋白质信息资源（PIR），蛋白质研究基金会 （PRF）或CDS翻译。

公开(公告)号：EP2407172A1

公开(公告)日：2012-01-18

申请号：EP11178673.7

申请日：2008-09-05

申请人： Peptcell Limited

发明人： Stoloff, Gregory Alan ,  Caparros-Wanderley, Wilson Romero

IPC分类号： A61K38/01 ,  C07K14/435

CPC分类号： C07K14/43577 ,  A61K38/00 ,  A61K39/005 ,  A61K2039/53 ,  Y10S530/806 ,  Y10S530/855 ,  Y10S530/858

摘要： Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40kDA or less, and wherein the polypeptides are selected independently from:
the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or
from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.

摘要翻译： 提供了一种多肽组合物，其包含一种或多种多肽，该多肽在脊椎动物中是免疫原性的，使得它们使脊椎动物产生能够识别节肢动物唾液蛋白质级分中的至少一个表位的免疫系统细胞，其中节肢动物唾液蛋白质级分具有 质量为40kDA或更小，并且其中所述多肽独立地选自：SEQ ID 1-44的多肽序列或来自这些序列的亚序列，所述亚序列具有7个氨基酸或更多个; 或来自与一个或多个上述序列具有85％同源性或更多的多肽序列，并且包含在一个或多个以下数据库中：GenBank，蛋白质数据库（PDB），SwissProt，蛋白质信息资源（PIR），蛋白质研究基金会 （PRF）或CDS翻译。