公开(公告)号：EP3126330B1

公开(公告)日：2019-02-27

申请号：EP15717250.3

申请日：2015-03-26

申请人： Pfizer Inc.

发明人： ANDERSON, David Randolph ,  BUNNAGE, Mark Edward ,  CURRAN, Kevin Joseph ,  DEHNHARDT, Christoph Martin ,  GAVRIN, Lori Krim ,  GOLDBERG, Joel Adam ,  HAN, Seungil ,  HEPWORTH, David ,  HUANG, Horng-Chih ,  LEE, Arthur ,  LEE, Katherine Lin ,  LOVERING, Frank Eldridge ,  LOWE, Michael Dennis ,  MATHIAS, John Paul ,  PAPAIOANNOU, Nikolaos ,  PATNY, Akshay ,  PIERCE, Betsy Susan ,  SAIAH, Eddine ,  STROHBACH, Joseph Walter ,  TRZUPEK, John David ,  VARGAS, Richard ,  WANG, Xiaolun ,  WRIGHT, Stephen Wayne ,  ZAPF, Christoph Wolfgang

IPC分类号： C07D207/26 ,  C07D207/273 ,  C07D209/52 ,  C07D215/48 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D239/86 ,  C07D239/88 ,  C07D263/24 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12

公开(公告)号：EP3858825A1

公开(公告)日：2021-08-04

申请号：EP21157042.9

申请日：2016-08-16

申请人： Pfizer Inc.

发明人： LEE, Katherine Lin ,  ALLAIS, Christophe Philippe ,  DEHNHARDT, Christoph Martin ,  GAVRIN, Lori Krim ,  HAN, Seungil ,  HEPWORTH, David ,  LEE, Arthur ,  LOVERING, Frank Eldridge ,  MATHIAS, John Paul ,  OWEN, Dafydd Rhys ,  PAPAIOANNOU, Nikolaos ,  SAIAH, Eddine ,  STROHBACH, Joseph Walter ,  TRZUPEK, John David ,  WRIGHT, Stephen Wayne ,  ZAPF, Christoph Wolfgang

IPC分类号： C07D401/12 ,  C07D413/14 ,  C07D401/14 ,  C07D491/18 ,  C07D471/04 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/4375 ,  C07D207/273 ,  A61P29/00 ,  A61P11/00 ,  A61P35/00 ,  A61P25/00

摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula IIc to IIi, IIl to IIv or IIx as defined in the claims. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

公开(公告)号：EP3536685A1

公开(公告)日：2019-09-11

申请号：EP19157789.9

申请日：2015-03-26

申请人： Pfizer Inc.

发明人： ANDERSON, David Randolph ,  BUNNAGE, Mark Edward ,  CURRAN, Kevin Joseph ,  DEHNHARDT, Christoph Martin ,  GAVRIN, Lori Krim ,  GOLDBERG, Joel Adam ,  HAN, Seungil ,  HEPWORTH, David ,  HUANG, Horng-Chih ,  LEE, Arthur ,  LEE, Katherine Lin ,  LOVERING, Frank Eldridge ,  LOWE, Michael Dennis ,  MATHIAS, John Paul ,  PAPAIOANNOU, Nikolaos ,  PATNY, Akshay ,  PIERCE, Betsy Susan ,  SAIAH, Eddine ,  STROHBACH, Joseph Walter ,  TRZUPEK, John David ,  VARGAS, Richard ,  WANG, Xiaolun ,  WRIGHT, Stephen Wayne ,  ZAPF, Christoph Wolfgang

IPC分类号： C07D207/26

摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia ,

as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment of autoimmune and inflammatory diseases associated with Interleukin-1 Receptor Associated Kinase (IRAK), methods of synthesis, and intermediates are also disclosed.

公开(公告)号：EP3341367A1

公开(公告)日：2018-07-04

申请号：EP16762869.2

申请日：2016-08-16

申请人： Pfizer Inc.

发明人： LEE, Katherine Lin ,  ALLAIS, Christophe Philippe ,  DEHNHARDT, Christoph Martin ,  GAVRIN, Lori Krim ,  HAN, Seungil ,  HEPWORTH, David ,  LEE, Arthur ,  LOVERING, Frank Eldridge ,  MATHIAS, John Paul ,  OWEN, Dafydd Rhys ,  PAPAIOANNOU, Nikolaos ,  SAIAH, Eddine ,  STROHBACH, Joseph Walter ,  TRZUPEK, John David ,  WRIGHT, Stephen Wayne ,  ZAPF, Christoph Wolfgang

IPC分类号： C07D401/12 ,  C07D413/14 ,  C07D401/14 ,  C07D491/18 ,  C07D471/04 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/4375 ,  C07D207/273 ,  A61P29/00 ,  A61P11/00 ,  A61P35/00 ,  A61P25/00

CPC分类号： C07D401/12 ,  A61K31/4015 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/4745 ,  A61K45/06 ,  C07D207/273 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D491/18

摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

公开(公告)号：EP3126330A1

公开(公告)日：2017-02-08

申请号：EP15717250.3

申请日：2015-03-26

申请人： Pfizer Inc.

发明人： ANDERSON, David Randolph ,  BUNNAGE, Mark Edward ,  CURRAN, Kevin Joseph ,  DEHNHARDT, Christoph Martin ,  GAVRIN, Lori Krim ,  GOLDBERG, Joel Adam ,  HAN, Seungil ,  HEPWORTH, David ,  HUANG, Horng-Chih ,  LEE, Arthur ,  LEE, Katherine Lin ,  LOVERING, Frank Eldridge ,  LOWE, Michael Dennis ,  MATHIAS, John Paul ,  PAPAIOANNOU, Nikolaos ,  PATNY, Akshay ,  PIERCE, Betsy Susan ,  SAIAH, Eddine ,  STROHBACH, Joseph Walter ,  TRZUPEK, John David ,  VARGAS, Richard ,  WANG, Xiaolun ,  WRIGHT, Stephen Wayne ,  ZAPF, Christoph Wolfgang

IPC分类号： C07D207/26 ,  C07D207/273 ,  C07D209/52 ,  C07D215/48 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D239/86 ,  C07D239/88 ,  C07D263/24 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12

CPC分类号： C07D491/056 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C69/94 ,  C07D207/08 ,  C07D207/26 ,  C07D207/267 ,  C07D207/273 ,  C07D209/52 ,  C07D215/48 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D239/86 ,  C07D239/88 ,  C07D263/24 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/14 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04 ,  C07F7/1804

摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

摘要翻译： 公开了化合物的化合物，互变异构体和药学上可接受的盐，其中化合物具有如说明书中定义的式Ia结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。