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1.发明公开
公开(公告)号：EP4263538A1
公开(公告)日：2023-10-25
申请号：EP21827674.9
申请日：2021-12-13
申请人： Pfizer Inc.
发明人： BAGLEY, Scott William , CASIMIRO-GARCIA, Agustin , DAVOREN, Jennifer Elizabeth , DENNY, Rajiah Aldrin , GERSTENBERGER, Brian Stephen , LEE, Katherine Lin , LOVERING, Frank Eldridge , PARIKH, Mihir Dineshkumar , STROHBACH, Joseph Walter , TRUJILLO, John Isidro
IPC分类号： C07D471/04 , A61K31/437 , A61P17/00
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公开(公告)号：EP3126330B1
公开(公告)日：2019-02-27
申请号：EP15717250.3
申请日：2015-03-26
申请人： Pfizer Inc.
发明人： ANDERSON, David Randolph , BUNNAGE, Mark Edward , CURRAN, Kevin Joseph , DEHNHARDT, Christoph Martin , GAVRIN, Lori Krim , GOLDBERG, Joel Adam , HAN, Seungil , HEPWORTH, David , HUANG, Horng-Chih , LEE, Arthur , LEE, Katherine Lin , LOVERING, Frank Eldridge , LOWE, Michael Dennis , MATHIAS, John Paul , PAPAIOANNOU, Nikolaos , PATNY, Akshay , PIERCE, Betsy Susan , SAIAH, Eddine , STROHBACH, Joseph Walter , TRZUPEK, John David , VARGAS, Richard , WANG, Xiaolun , WRIGHT, Stephen Wayne , ZAPF, Christoph Wolfgang
IPC分类号： C07D207/26 , C07D207/273 , C07D209/52 , C07D215/48 , C07D217/02 , C07D217/22 , C07D217/24 , C07D239/86 , C07D239/88 , C07D263/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12
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公开(公告)号：EP3143021B1
公开(公告)日：2019-06-12
申请号：EP15724365.0
申请日：2015-04-30
申请人： Pfizer Inc.
发明人： COE, Jotham Wadsworth , DEHNHARDT, Christoph Martin , JONES, Peter , SABNIS, Yogesh Anil , STROHBACH, Joseph Walter , WAKENHUT, Florian Michel , WHITLOCK, Gavin Alistair
IPC分类号： A61K31/437 , A61K31/4725 , A61K31/519 , C07D471/04 , C07D487/04
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公开(公告)号：EP3484876A1
公开(公告)日：2019-05-22
申请号：EP17740116.3
申请日：2017-07-07
申请人： Pfizer Inc.
发明人： CASIMIRO-GARCIA, Agustin , STROHBACH, Joseph Walter , HEPWORTH, David , LOVERING, Frank Eldridge , CHOI, Chulho , ALLAIS, Christophe Philippe , WRIGHT, Stephen Wayne
IPC分类号： C07D403/14 , C07D401/14 , C07D413/14 , C07D471/08 , C07D487/04 , C07D487/10 , C07D491/107 , C07D498/10 , C07D498/18 , A61K31/506 , A61P29/00
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公开(公告)号：EP3303303A1
公开(公告)日：2018-04-11
申请号：EP16724127.2
申请日：2016-05-16
申请人： Pfizer Inc.
发明人： CASIMIRO-GARCIA, Agustin , CONDON, Jeffrey Scott , FLICK, Andrew Christopher , GOPALSAMY, Ariamala , KIRINCICH, Steven J. , MATHIAS, John Paul , STROHBACH, Joseph Walter , XIANG, Jason Shaoyun , XING, Li Huang , WANG, Xiaolun
IPC分类号： C07D239/28 , C07D241/14 , A61K31/505 , A61P29/00
CPC分类号： C07D239/42 , A61K31/505 , A61P1/00 , A61P1/04 , A61P35/00 , C07D239/28 , C07D241/14 , C07D401/12 , C07D403/12 , C07D405/10
摘要： Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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6.发明公开BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS 审中-公开BICYCLISCHE-KONDENSIERTE HETEROARYL- ODER ARYLVERBINDUNGEN UND DEREN VERWENDUNG ALS IRAK4-INHIBITOREN
公开(公告)号：EP3126330A1
公开(公告)日：2017-02-08
申请号：EP15717250.3
申请日：2015-03-26
申请人： Pfizer Inc.
发明人： ANDERSON, David Randolph , BUNNAGE, Mark Edward , CURRAN, Kevin Joseph , DEHNHARDT, Christoph Martin , GAVRIN, Lori Krim , GOLDBERG, Joel Adam , HAN, Seungil , HEPWORTH, David , HUANG, Horng-Chih , LEE, Arthur , LEE, Katherine Lin , LOVERING, Frank Eldridge , LOWE, Michael Dennis , MATHIAS, John Paul , PAPAIOANNOU, Nikolaos , PATNY, Akshay , PIERCE, Betsy Susan , SAIAH, Eddine , STROHBACH, Joseph Walter , TRZUPEK, John David , VARGAS, Richard , WANG, Xiaolun , WRIGHT, Stephen Wayne , ZAPF, Christoph Wolfgang
IPC分类号： C07D207/26 , C07D207/273 , C07D209/52 , C07D215/48 , C07D217/02 , C07D217/22 , C07D217/24 , C07D239/86 , C07D239/88 , C07D263/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12
CPC分类号： C07D491/056 , A61K31/40 , A61K31/4015 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C69/94 , C07D207/08 , C07D207/26 , C07D207/267 , C07D207/273 , C07D209/52 , C07D215/48 , C07D217/02 , C07D217/22 , C07D217/24 , C07D239/86 , C07D239/88 , C07D263/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D498/04 , C07F7/1804
摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译： 公开了化合物的化合物，互变异构体和药学上可接受的盐，其中化合物具有如说明书中定义的式Ia结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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公开(公告)号：EP4157845A1
公开(公告)日：2023-04-05
申请号：EP21729021.2
申请日：2021-05-25
申请人： Pfizer Inc.
发明人： DOWTY, Martin Eugene , MALHOTRA, Bimal Kumar , SAMARDJIEV, Ivan Jordan , SAMAS, Brian Matthew , STROHBACH, Joseph Walter
IPC分类号： C07D487/04 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61K31/5377
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公开(公告)号：EP3861001A1
公开(公告)日：2021-08-11
申请号：EP19782756.1
申请日：2019-10-01
申请人： Pfizer Inc.
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9.发明公开COMBINATION OF PYRROLO [2, 3 -D]PYRIMIDINE DERIVATIVES WITH ONE OR MORE ADDITIONAL AGENTS AS INHIBITORS OF JANUS- RELATED KINASES (JAK) 审中-公开吡咯并[2,3-d]嘧啶衍生物与一种或多种附加药物作为JANUS-相关激酶抑制剂（JAK）的组合
公开(公告)号：EP3290421A1
公开(公告)日：2018-03-07
申请号：EP17191163.9
申请日：2014-02-11
申请人： Pfizer Inc.
发明人： BROWN, Matthew Frank , FENWICK, Ashley Edward , FLANAGAN, Mark Edward , GONZALES, Andrea , JOHNSON, Timothy Allan , KAILA, Neelu , MITTON-FRY, Mark J. , STROHBACH, Joseph Walter , TENBRINK, Ruth E. , TRZUPEK, John David , UNWALLA, Rayomand Jal , VAZQUEZ, Michael L. , PARIKH, Mihir, D.
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , A61P37/00
CPC分类号： A61K31/519 , A61K31/5386 , C07D207/18 , C07D487/04 , C07D519/00
摘要： Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.
摘要翻译： 本文描述了吡咯并（2,3-d）嘧啶衍生物，它们作为Janus激酶（JAK）抑制剂的用途以及包含它们的药物组合物。
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10.发明公开
公开(公告)号：EP4263526A1
公开(公告)日：2023-10-25
申请号：EP21827671.5
申请日：2021-12-13
申请人： Pfizer Inc.
发明人： BAGLEY, Scott William , CASIMIRO-GARCIA, Agustin , DAVOREN, Jennifer Elizabeth , DENNY, Rajiah Aldrin , GERSTENBERGER, Brian Stephen , LOVERING, Frank Eldridge , PARIKH, Mihir Dineshkumar , STROHBACH, Joseph Walter , TRUJILLO, John Isidro
IPC分类号： C07D403/04 , A61K31/4184 , A61P17/00
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