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1.发明授权3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 氨基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202733B1
公开(公告)日：2005-10-05
申请号：EP00931906.2
申请日：2000-05-05
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S. , BRASCA, Maria, Grabriella
IPC分类号： A61K31/415 , C07D231/40 , C07D231/16
CPC分类号： C07D403/12 , A61K31/415 , A61K31/4155 , A61K45/06 , C07D231/16 , C07D231/40 , C07D405/12 , C07D409/12
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2.发明公开SUBSTITUTED AMINOETHERS FOR THE TREATMENT OF ALZHEIMER S DISEASE 审中-公开比利时国际电力公司（IHRE VERWENDUNG ZUR BEHANDLUNG VON ALZHEIMER）
公开(公告)号：EP1537072A1
公开(公告)日：2005-06-08
申请号：EP03755809.5
申请日：2003-09-10
IPC分类号： C07C233/78 , C07C255/57 , C07D263/32 , C07D277/30 , C07C237/34 , C07D413/04 , C07D213/81 , C07D413/12 , C07D213/30 , C07D239/26 , A61K31/166 , A61K31/277 , A61K31/421 , A61K31/426 , A61K31/4439
CPC分类号： C07C233/78 , C07C237/34 , C07C255/57 , C07C2601/02 , C07D213/30 , C07D213/81 , C07D239/26 , C07D263/32 , C07D277/30 , C07D413/04
摘要： The invention provides compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
摘要翻译： 本发明提供式（I）化合物：可用于治疗阿尔茨海默病和其他类似疾病。 这些化合物包括β-分泌酶的抑制剂，其可用于治疗阿尔茨海默病和以哺乳动物中Aβ肽沉积为特征的其它疾病。 本发明的化合物可用于降低Aβ肽形成的药物组合物和治疗方法。
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3.发明授权3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 脲基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202734B1
公开(公告)日：2007-05-02
申请号：EP00955241.5
申请日：2000-08-11
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S.
IPC分类号： A61K31/415 , A61K31/496 , C07D231/40 , C07D403/12
CPC分类号： C07D231/40 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/5377
摘要： 3-ureido-pyrazole derivatives represented by formula (I): where R, R1 and R2 are as described herein, or pharmaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.
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4.发明公开3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 脲基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202734A1
公开(公告)日：2002-05-08
申请号：EP00955241.5
申请日：2000-08-11
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S.
IPC分类号： A61K31/415 , A61K31/496 , C07D231/40 , C07D403/12
CPC分类号： C07D231/40 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/5377
摘要： 3-ureido-pyrazole derivatives represented by formula (I): where R, R1 and R2 are as described herein, or pharmaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.
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5.发明公开3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 氨基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202733A1
公开(公告)日：2002-05-08
申请号：EP00931906.2
申请日：2000-05-05
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S. , BRASCA, Maria, Grabriella
IPC分类号： A61K31/415 , C07D231/40
CPC分类号： C07D403/12 , A61K31/415 , A61K31/4155 , A61K45/06 , C07D231/16 , C07D231/40 , C07D405/12 , C07D409/12
摘要： Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C3-C6 cycloalkyl group optionally substituted by a straight or branched C1-C6 alkyl or arylalkyl group; R1 is a straight or branched C1-C6 alkyl, C2-C4 alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl or arylalkenyl group, each of which may be optionally further substituted as indicated in the description; or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.
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