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1.发明公开3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 氨基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202733A1
公开(公告)日：2002-05-08
申请号：EP00931906.2
申请日：2000-05-05
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S. , BRASCA, Maria, Grabriella
IPC分类号： A61K31/415 , C07D231/40
CPC分类号： C07D403/12 , A61K31/415 , A61K31/4155 , A61K45/06 , C07D231/16 , C07D231/40 , C07D405/12 , C07D409/12
摘要： Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C3-C6 cycloalkyl group optionally substituted by a straight or branched C1-C6 alkyl or arylalkyl group; R1 is a straight or branched C1-C6 alkyl, C2-C4 alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl or arylalkenyl group, each of which may be optionally further substituted as indicated in the description; or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.
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2.发明公开3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 脲基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202734A1
公开(公告)日：2002-05-08
申请号：EP00955241.5
申请日：2000-08-11
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S.
IPC分类号： A61K31/415 , A61K31/496 , C07D231/40 , C07D403/12
CPC分类号： C07D231/40 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/5377
摘要： 3-ureido-pyrazole derivatives represented by formula (I): where R, R1 and R2 are as described herein, or pharmaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.
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3.发明授权3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 氨基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202733B1
公开(公告)日：2005-10-05
申请号：EP00931906.2
申请日：2000-05-05
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S. , BRASCA, Maria, Grabriella
IPC分类号： A61K31/415 , C07D231/40 , C07D231/16
CPC分类号： C07D403/12 , A61K31/415 , A61K31/4155 , A61K45/06 , C07D231/16 , C07D231/40 , C07D405/12 , C07D409/12
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公开(公告)号：EP1644376A1
公开(公告)日：2006-04-12
申请号：EP04763132.0
申请日：2004-07-08
IPC分类号： C07D487/04 , A61K31/4162 , A61P35/00
CPC分类号： C07D487/04
摘要： Pyrrolo[3,4-c]pyrazole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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5.发明公开BICYCLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开双环吡唑衍生物激酶抑制剂，PROCESS FOR THEIR和药物成分，以便
公开(公告)号：EP1608364A1
公开(公告)日：2005-12-28
申请号：EP04716253.2
申请日：2004-03-02
IPC分类号： A61K31/4162 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/4745 , A61K31/55
摘要： Compounds which are pyrrolo-pyrazole derivatives and pharmaceutically acceptable salts thereof, together with the process for their preparation and pharmaceutical compositions thereof are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
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公开(公告)号：EP1177185B1
公开(公告)日：2005-04-20
申请号：EP00927184.2
申请日：2000-05-04
IPC分类号： C07D401/04 , C07D231/56 , A61K31/416 , A61P35/00
CPC分类号： C07D401/04 , C07D231/56
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7.发明授权AMINO ANTHRACYCLINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AMYLOIDOSIS 有权AMINOANTHRACYCLINONDERIVATE及其用于治疗淀粉样变性
公开(公告)号：EP1062206B1
公开(公告)日：2004-04-14
申请号：EP99910304.7
申请日：1999-02-25
发明人： BANDIERA, Tiziano , FANCELLI, Daniele , VARASI, Mario , CARUSO, Michele , LANSEN, Jacqueline , SUARATO, Antonino
IPC分类号： C07D211/70 , C07D405/06 , A61K31/65
CPC分类号： C07D405/06 , C07D211/70
摘要： A compound of formula (1), wherein R1 represents hydrogen, hydroxy, a group of formula OR7, wherein R7 is C1-C6 alkyl, C2-C6 alkenyl; R2 represents hydrogen, hydroxy, diethylamino, piperidino, tetrahydropyridino or morpholino, and either R3, taken alone, represents hydrogen or hydroxy, and R4 and R5, taken alone, independently represent hydrogen, hydroxy or, taken together with the carbon atom, represent a carbonyl group; or R3 and R4, taken together, represent a group of formula (A), wherein R8 and R9 represent a C1-C6 alkyl and R5 represents hydrogen; R6 represents hydrogen or a phenyl group, optionally substituted by methyl, methoxy or halogen and the pharmaceutically acceptable salt thereof, is useful in the treatment of amyloidosis. Processes for the preparation and pharmaceutical compositions are also described.
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8.发明公开
公开(公告)号：EP1320531A2
公开(公告)日：2003-06-25
申请号：EP01967223.7
申请日：2001-07-25
IPC分类号： C07D487/04 , C07D471/04 , A61K31/4162 , A61K31/437 , A61P35/00 , A61P25/00 , A61P31/12
CPC分类号： C07D487/04 , C07D471/04 , C40B40/00
摘要： Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.
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9.发明公开THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开噻吩衍生物作为激酶抑制剂; 工艺生产同样和药物组合物含有该
公开(公告)号：EP1294707A2
公开(公告)日：2003-03-26
申请号：EP01964983.9
申请日：2001-06-14
IPC分类号： C07D333/38 , C07D333/68 , C07D417/04 , C07D409/04 , C07D515/04 , A61P35/00
CPC分类号： C07D409/12 , C07D333/38 , C07D333/68 , C07D413/12 , C07D473/00 , C07D495/04
摘要： Compounds which are 3-aminocarbonyl-2-carboxamido-thiophene derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
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10.发明授权3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 脲基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202734B1
公开(公告)日：2007-05-02
申请号：EP00955241.5
申请日：2000-08-11
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S.
IPC分类号： A61K31/415 , A61K31/496 , C07D231/40 , C07D403/12
CPC分类号： C07D231/40 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/5377
摘要： 3-ureido-pyrazole derivatives represented by formula (I): where R, R1 and R2 are as described herein, or pharmaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.
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