公开(公告)号：EP1165492A1

公开(公告)日：2002-01-02

申请号：EP00913980.9

申请日：2000-03-27

申请人： Pharmacor Inc.

发明人： SAUVE, Gilles ,  YELLE, Jocelyn

IPC分类号： C07C237/22 ,  C07D209/20 ,  C07D233/64 ,  C07C323/60 ,  C07K5/06 ,  A61K31/165 ,  A61K38/05 ,  A61P31/18

CPC分类号： C07K5/06026 ,  A61K38/00 ,  C07C237/22 ,  C07C323/60 ,  C07K5/06078

摘要： An hydroxphenyl derivative selected from the group consisting of a compound of formula (I), (II) and comprises a carboxylic acid group when a compound of formula (I) pharmaceutically acceptable salts thereof and when a compound of formula (I) comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein n is 1, 2 or 3, e is 1, 2 or 3, Hal represents a halogen atom (e.g. Cl, Br, F or I), p is 0, 1 or 2, r is 0, 1 or 2, X and X' each independently represents a single bond, a saturated straight or branched hydrocarbon group of 1 to 4 carbon atoms or a straigth or branched hydrocarbon group of 2 to 4 carbon atoms comprising a carbon to carbon double bond, Ra represents H or -CH3, and Raa represents H or -CH3; W may represent an amino acid residue or fragment. These compounds may be used to inhibit the activity of HIV integrase.

公开(公告)号：EP1263716A2

公开(公告)日：2002-12-11

申请号：EP01914865.9

申请日：2001-03-07

申请人： Pharmacor Inc.

发明人： STRANIX, Brent, Richard ,  SAUVE, Gilles ,  BOUZIDE, Abderrahim ,  SEVIGNY, Guy ,  YELLE, Jocelyn

IPC分类号： C07C311/19 ,  C07C311/29 ,  C07C311/18 ,  C07C311/10 ,  C07C311/42 ,  C07C311/13 ,  C07C311/46 ,  C07C271/22 ,  A61K31/325 ,  A61K31/395

CPC分类号： C07D215/36 ,  C07C271/22 ,  C07C311/10 ,  C07C311/13 ,  C07C311/19 ,  C07C311/29 ,  C07C311/42 ,  C07C323/60 ,  C07C2601/02 ,  C07C2602/42 ,  C07C2603/18 ,  C07D209/18 ,  C07D209/42 ,  C07D215/48 ,  C07D311/84 ,  C07D317/60

摘要： The present invention relates to a class of amino acid derivatives with HIV aspartyl protease inhibitory properties.

摘要翻译： 本发明涉及一类具有HIV天冬氨酰蛋白酶抑制性质的氨基酸衍生物。

公开(公告)号：EP1377542A1

公开(公告)日：2004-01-07

申请号：EP02704504.6

申请日：2002-02-12

申请人： Pharmacor Inc.

发明人： STRANIX, Brent, Richard ,  SAUVE, Gilles ,  BOUZIDE, Abderrahim ,  COTE, Alexandre ,  BERUBE, Gervais ,  SOUCY, Patrick ,  ZHAO, Yongsen ,  YELLE, Jocelyn

IPC分类号： C07C311/19 ,  C07D209/16 ,  C07C311/46 ,  C07D333/34 ,  C07D333/60 ,  C07C311/42 ,  C07D295/215 ,  C07C327/48 ,  C07D409/12 ,  A61K31/198 ,  A61K31/405 ,  A61K31/381 ,  A61K31/5375 ,  A61P31/18

CPC分类号： C07D295/185 ,  A61K38/00 ,  C07C311/19 ,  C07C311/42 ,  C07C311/46 ,  C07C323/60 ,  C07C327/44 ,  C07C327/48 ,  C07C2601/08 ,  C07D209/16 ,  C07D333/34 ,  C07D333/60 ,  C07K5/0215

摘要： A compound selected from the group consisting of a compound of formula I or formula II: (I) (II) wherein n is 3 or 4 wherein Cx is selected from the group consisting of -COOM, COOR6, -CHO, -CH2OR7, -CH2OCOR8, -CONHR9 and -CONR10R11, wherein M is an alkali metal or alkaline earth metal, wherein R2 is selected from the group consisting of a benzenesulfonyl group of formula III, or formula IV : (III) (IV) and when the compound of formula (I) and (II) comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.

公开(公告)号：EP1175385A1

公开(公告)日：2002-01-30

申请号：EP00922387.6

申请日：2000-04-27

申请人： Pharmacor Inc.

发明人： SAUVE, Gilles ,  BOUZIDE, Abderrahim

IPC分类号： C07C43/178 ,  C07C43/13 ,  A61K31/075 ,  A61P31/18

CPC分类号： C07D213/30 ,  C07C43/135 ,  C07C43/178 ,  C07C43/1781 ,  C07C43/1785 ,  C07C43/1786 ,  C07C45/44 ,  C07C47/575 ,  C07C69/76 ,  C07C205/37 ,  C07C217/48 ,  C07C217/76 ,  C07C235/46 ,  C07C255/54 ,  C07C255/57 ,  C07C271/28 ,  C07C323/12 ,  C07C329/16 ,  C07D333/16

摘要： A D-mannitol derivative selected from the group consisting of a compound of formula (I) pharmaceutically acceptable derivatives thereof and where applicable or appropriate pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are the same or different and may, for example, each independently be selected from among alkyl and aryl (i.e. aromatic including aromatic like) groups. The D-mannitol derivatives may be used as HIV aspartyl protease inhibitors.