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1.发明公开PROPANE- I-SULFONIC ACID {3- [5- (4 -CHLORO-PHENYL) -1H-PYRROLO [2, 3-B] PYRIDINE-3-CARBONYL] -2, 4-DIFLUORO-PHENY L } -AMIDE COMPOSITIONS AND USES THEREOF 有权丙烷-1-磺酸{3- [5-（4-氯苯基）-1H-吡咯并[2,3-b]吡啶-3-羰基] -2,4-二氟苯基}酰胺的组合物及其应用
公开(公告)号：EP2414356A2
公开(公告)日：2012-02-08
申请号：EP10722860.3
申请日：2010-03-31
发明人： DESAI, Dipen , DIODONE, Ralph , GO, Zenaida , IBRAHIM, Prabha, N. , IYER, Raman, Mahadevan , MAIR, Hans-Juergen , SANDHU, Harpreet, K. , SHAH, Navnit, Hargovindas , VISOR, Gary, Conard , WYTTENBACH, Nicole , LAUPER, Stephan , PUDEWELL, Johannes , WIERSCHEM, Frank
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
CPC分类号： C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K31/437 , C07B2200/13
摘要： Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1 -sulfonic acid {3-[5-(4-chloro-pheny!)-lH-pyrrolo[2,3-b]pyridine-3-carbonyl]- 2,4-difluoro-phenyl} -amide. (Formula I).
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公开(公告)号：EP2678075A1
公开(公告)日：2014-01-01
申请号：EP12789648.8
申请日：2012-02-21
发明人： DIODONE, Ralph , FAEHNRICH, Karsten , IBRAHIM, Prabha, N. , KUANG, Shan-ming , VISOR, Gary, Conard , ZHAO, Baoshu , SCHWITTER, Urs
IPC分类号： A61P35/00
CPC分类号： C07D471/04 , A61K31/437
摘要： The present invention provides solid forms of the compound of formula 1 and pharmaceutical uses thereof. (I)
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3.发明授权PROPANE-I-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF 有权丙烷-1-磺酸{3- [5-（4-氯苯基）-1H-吡咯并[2,3-b]吡啶-3-羰基] -2,4-二氟苯基}酰胺的组合物及其应用
公开(公告)号：EP2414356B1
公开(公告)日：2015-09-02
申请号：EP10722860.3
申请日：2010-03-31
发明人： DESAI, Dipen , DIODONE, Ralph , GO, Zenaida , IBRAHIM, Prabha, N. , IYER, Raman, Mahadevan , MAIR, Hans-Juergen , SANDHU, Harpreet, K. , SHAH, Navnit, Hargovindas , VISOR, Gary, Conard , WYTTENBACH, Nicole , LAUPER, Stephan , PUDEWELL, Johannes , WIERSCHEM, Frank
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
CPC分类号： C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K31/437 , C07B2200/13
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公开(公告)号：EP2970265B1
公开(公告)日：2018-08-08
申请号：EP14715529.5
申请日：2014-03-14
申请人： PLEXXIKON INC.
发明人： ZHANG, Jiazhong , BUELL, John , CHAN, Katrina , IBRAHIM, Prabha, N. , LIN, Jack , PHAM, Phuongly , SHI, Songyuan , SPEVAK, Wayne , WU, Guoxian , WU, Jeffrey
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07F9/6561 , A61K31/422 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/675 , A61K31/695 , C07D413/04 , C07D413/14 , C07D471/04 , C07F7/10 , Y02A50/411
摘要： Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.
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公开(公告)号：EP2935248B1
公开(公告)日：2018-02-28
申请号：EP13824239.1
申请日：2013-12-20
申请人： Plexxikon Inc.
发明人： WU, Guoxian , CHAN, Katrina , EWING, Todd , IBRAHIM, Prabha, N. , LIN, Jack , NESPI, Marika , SPEVAK, Wayne , ZHANG, Ying
IPC分类号： C07D403/12 , C07D401/12 , C07D471/04 , C07D487/04 , C07D513/04 , A61K31/437 , A61P35/00
CPC分类号： C07D401/12 , A61K31/437 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/675 , C07D403/12 , C07D471/04 , C07D487/04 , C07D513/04 , C07F5/025 , C07F9/65616
摘要： Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.
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公开(公告)号：EP2496086B1
公开(公告)日：2017-05-31
申请号：EP10829123.8
申请日：2010-11-04
申请人： Plexxikon Inc.
IPC分类号： A01N43/90 , A61K31/519
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4427 , A61K31/506 , C07D401/04 , C07D401/14
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7.发明公开1 , 4 AND 1 , 5-DISUBSTITUTED INDOLE DERIVATIVES FOR USE AS PPAR ACTIVE COMPOUNDS 审中-公开二取代FOR USE AS PPAR活性化合物1,4-和1,5-吲哚衍生物
公开(公告)号：EP1931658A2
公开(公告)日：2008-06-18
申请号：EP06814251.2
申请日：2006-09-06
申请人： PLEXXIKON, INC.
发明人： LIN, Jack , SHI, Shenghua , ZHANG, Chao , ZUCKERMAN, Rebecca , ARTIS, Dean, R. , IBRAHIM, Prabha, N. , LEE, Byunghun
IPC分类号： C07D409/12 , C07D409/14 , C07D209/08 , A61K31/405 , A61P3/10
CPC分类号： C07D409/12 , C07D209/08 , C07D409/14
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARϜ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARϜ . wherein R1 is selected from the group consisting of -C(O)OR18R19, and a carboxylic acid isostere.
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公开(公告)号：EP3292123A1
公开(公告)日：2018-03-14
申请号：EP16723225.5
申请日：2016-05-05
申请人： Plexxikon, Inc.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Also provided are methods of using the solid forms.
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公开(公告)号：EP2970265A1
公开(公告)日：2016-01-20
申请号：EP14715529.5
申请日：2014-03-14
申请人： PLEXXIKON INC.
发明人： ZHANG, Jiazhong , BUELL, John , CHAN, Katrina , IBRAHIM, Prabha, N. , LIN, Jack , PHAM, Phuongly , SHI, Songyuan , SPEVAK, Wayne , WU, Guoxian , WU, Jeffrey
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07F9/6561 , A61K31/422 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/675 , A61K31/695 , C07D413/04 , C07D413/14 , C07D471/04 , C07F7/10 , Y02A50/411
摘要： Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.
摘要翻译： 式（I）的杂环化合物，其制备方法，含有这种化合物的药物组合物及其治疗用途。
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10.发明公开
公开(公告)号：EP1885723A2
公开(公告)日：2008-02-13
申请号：EP06813186.1
申请日：2006-05-16
申请人： PLEXXIKON, INC.
发明人： ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha, N. , HURT, Clarence, R. , ZUCKERMAN, Rebecca , ARTIS, Dean, R. , BREMER, Ryan , SPEVAK, Wayne , WU, Guoxian , ZHU, Hongyao
IPC分类号： C07D471/04 , A61K31/435 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
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