公开(公告)号：EP2480897A2

公开(公告)日：2012-08-01

申请号：EP10818021.7

申请日：2010-09-21

Applicant: Pocared Diagnostics Ltd

Inventor： INGBER, Gal ,  ATTERBURY, William, G. ,  HOLLEY, Dave ,  KLAUSING, Thomas, A. ,  LAUDO, John, S. ,  SCHAEFER, Jason, A. ,  TALBERT, Sherwood ,  TALLARICO, John

IPC: G01N35/02 ,  C12M1/38 ,  C12Q1/04 ,  C12Q1/06

CPC classification number: G01N35/025 ,  B04B9/14 ,  G01N2035/00504 ,  G01N2035/0434 ,  G01N2035/0458

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.

公开(公告)号：EP2931915A1

公开(公告)日：2015-10-21

申请号：EP13861869.9

申请日：2013-12-11

Applicant: Pocared Diagnostics Ltd

Inventor： INGBER, Gal ,  ROGERS, Martha, J.

IPC: C12Q1/04 ,  G01N33/48 ,  G01N21/51

CPC classification number: C12M41/36 ,  B01L3/508 ,  B01L2300/0809 ,  B01L2300/0851 ,  G01N21/0303 ,  G01N2021/0382 ,  G01N2021/6469 ,  G01N2021/6482 ,  G01N2035/0436 ,  G01N2201/0655

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optics cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light. The system may utilize the disposable cartridge in the sample processor and the optics cup or cuvette in the optical analyzer, wherein the optics cup also has a floor in the shape of an inverted arch.

Abstract translation: 本发明涉及一种用于对生物样品中的微生物（例如细菌）进行鉴定和定量的系统。 更具体地说，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或比色杯的系统; 其中壁成角度以允许更好的涂层和更好的光线条纹。 该系统可以利用样本处理器中的一次性盒和光学分析器中的光学杯或比色皿，其中光学杯还具有倒拱形状的底面。

公开(公告)号：EP3265941A1

公开(公告)日：2018-01-10

申请号：EP16761164.9

申请日：2016-03-04

Applicant: Pocared Diagnostics Ltd.

Inventor： GURFINKEL, Jonathan ,  INGBER, Gal

IPC: G06F19/00

CPC classification number: G01N21/6486 ,  C12Q1/04 ,  G01N33/4833 ,  G01N2021/6417 ,  G01N2201/062 ,  G01N2201/129

Abstract: This invention relates to a method that allows for the differentiation of isolates of commonly encountered bacteria that contain specific antibiotic-resistance genes from similar isolates that do not harbor the gene. More particularly, the invention relates to a method that utilizes an automated rapid platform system that employs intrinsic fluorescence, optical data analysis, and artificial intelligence methods to analyze multi-dimensional optical characteristics of bacterial strains.

公开(公告)号：EP2635670B1

公开(公告)日：2017-08-23

申请号：EP11838716.6

申请日：2011-11-02

Applicant: Pocared Diagnostics Ltd

Inventor： INGBER, Gal

IPC: G01N21/03 ,  C12M1/34 ,  B01L3/00 ,  G01N35/02 ,  G01N21/64 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01N21/0303 ,  B01L3/508 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/12 ,  B01L2300/0809 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/168 ,  C12M41/36 ,  G01N21/6452 ,  G01N35/025 ,  G01N2021/0321 ,  G01N2021/0382 ,  G01N2021/6469 ,  G01N2021/6482 ,  G01N2035/00346 ,  G01N2035/0429 ,  G01N2035/0449

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.

Abstract translation: 本发明涉及一种用于对微生物（例如生物样品中的细菌）进行鉴定和定量的系统。 更具体地说，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或比色皿的系统; 其中所述壁成角度以允许更好的涂层和更好的光线条纹，光学系统包括光学读取器和热控制器; 光学分析仪; 一个冷却系统; 和一个改进的光谱仪。 该系统可以利用样本处理器中的一次性盒和光学分析器中的光学杯或比色皿。

公开(公告)号：EP2209904B1

公开(公告)日：2017-03-01

申请号：EP08837688.4

申请日：2008-10-10

Applicant: Pocared Diagnostics Ltd.

Inventor： INGBER, Gal ,  ATTERBURY, William, G. ,  BARNES, Russell, H. ,  BOYD, Douglas, E. ,  DENNIS, Joseph, D. ,  GURFINKEL, Jonathan ,  HOLLEY, Dave ,  HUCKABY, Steven, E. ,  KLAUSING, Thomas, A. ,  LAUDO, John, S. ,  SADESKI, Kevin ,  SCHAEFER, Jason, A. ,  SCOTT, K., Bryan ,  STILLMAN, Carol ,  TALBERT, Sherwood ,  TALLARICO, John

IPC: C12Q1/04 ,  G01N33/49 ,  G01N33/493 ,  G01N35/02 ,  G01N21/03 ,  G01N21/64 ,  G01N35/04

CPC classification number: G01N33/493 ,  C12Q1/04 ,  G01N21/0303 ,  G01N35/025 ,  G01N35/04 ,  G01N2021/6482 ,  G01N2035/0436 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0458 ,  G01N2201/0415

公开(公告)号：EP2394147A1

公开(公告)日：2011-12-14

申请号：EP10738280.6

申请日：2010-02-07

Applicant: Pocared Diagnostics Ltd.

Inventor： INGBER, Gal

IPC: G01J3/42

CPC classification number: G01J1/32 ,  G01J3/42 ,  G01J2003/2866 ,  G01N21/031 ,  G01N21/253 ,  G01N2201/0415 ,  G01N2201/0469 ,  G01N2201/0692

Abstract: A method and device for enhancing the power correction of optical measurements in an optical measurement arrangement, the steps including: providing a light source for producing a light beam; splitting the light beam into two beams; directing a first split light beam through an interrogation area and into an optics separation device; directing the light beams from the optics separation device and a second split light beam representing the intensity of the illumination of the main light beam of the light source into cells of a detector array; measuring and assessing the information obtained in the cells; and using this information to calculate the corrected value for the cells receiving the light beams from the optics separation device in order to adjust the power for the intensity of the light beam of the light source and/or to correct the intensity of the light beams from the interrogation area.

公开(公告)号：EP2245467A2

公开(公告)日：2010-11-03

申请号：EP09707459.5

申请日：2009-02-05

Applicant: Pocared Diagnostics Ltd.

Inventor： INGBER, Gal ,  ATTERBURY, William, G. ,  HOLLEY, Dave ,  LAUDO, John, S. ,  SCHAEFER, Jason, A. ,  TALBERT, Sherwood ,  TALLARICO, John ,  KLAUSING, Thomas, A.

IPC: G01N35/02 ,  G01N21/03

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  B01L3/50851 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2300/0609 ,  B01L2300/0809 ,  B01L2300/0851 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1844 ,  C12M41/36 ,  G01N21/0303 ,  G01N21/0332 ,  G01N35/026 ,  G01N2021/0382 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6482 ,  G01N2035/00346 ,  G01N2035/0429 ,  G01N2035/0449 ,  G01N2201/0633

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.

Abstract translation: 本发明涉及用于进行微生物（例如生物样品中的细菌）的鉴定和定量的系统。 更具体地，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或比色杯的系统; 包括光学读取器和热控制器的光学系统; 光学分析仪; 冷却系统; 和改进的光谱仪。 该系统可以利用样品处理器中的一次性盒，以及光学分析仪中的光学杯或比色皿。

公开(公告)号：EP3077505A1

公开(公告)日：2016-10-12

申请号：EP14868655.3

申请日：2014-12-04

Applicant: Pocared Diagnostics Ltd

Inventor： GURFINKEL, Jonathan ,  INGBER, Gal

IPC: C12N7/02 ,  B01D27/14 ,  G01N33/487 ,  B01D61/18 ,  B01D61/20

CPC classification number: B01D29/0095 ,  B01D37/00 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/065 ,  C12Q1/24 ,  G01F15/125 ,  G01G17/06 ,  G01N1/2813 ,  G01N1/30 ,  G01N1/4077 ,  G01N5/02 ,  G01N33/493 ,  G01N2001/4088 ,  G01N2015/0053 ,  Y10T436/25375

Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.

公开(公告)号：EP2953703A1

公开(公告)日：2015-12-16

申请号：EP14749421.5

申请日：2014-02-04

Applicant: Pocared Diagnostics Ltd

Inventor： INGBER, Gal

IPC: B01D37/00 ,  B01D29/01 ,  B01D27/08 ,  B01D35/30 ,  B01D29/62 ,  B01D29/88

CPC classification number: G01N1/34 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/049 ,  G01N1/4077 ,  G01N2001/4088

Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. In an intermediate step, the particles captured by the filter may be rinsed with a rinsing fluid such as water to pass additional undersized particles through the filter, thereby providing a purer sample. To improve efficiency, check valves may be used for passageways with one-way flow. Additionally, a configuration of three-way stopcocks may also be utilized. Finally, a sandwich arrangement is possible, wherein a single bottom element is sandwiched between two opposing top elements.

Abstract translation: 具有顶部元件和底部元件以及过滤元件的过滤器装置在过滤器元件的上表面之间捕获过大的颗粒，并使用洗脱流体切向冲洗这些颗粒，以提供相对低体积流体中的颗粒浓度 进一步分析。 在中间步骤中，由过滤器捕获的颗粒可以用诸如水的冲洗流体冲洗以通过另外的过小的颗粒通过过滤器，从而提供更纯的样品。 为了提高效率，止回阀可用于单向流动的通道。 此外，还可以使用三通旋塞的构造。 最后，三明治布置是可能的，其中单个底部元件夹在两个相对的顶部元件之间。

公开(公告)号：EP2209904A2

公开(公告)日：2010-07-28

申请号：EP08837688.4

申请日：2008-10-10

Applicant: Pocared Diagnostics Ltd.

Inventor： INGBER, Gal ,  ATTERBURY, William, G. ,  BARNES, Russell, H. ,  BOYD, Douglas, E. ,  DENNIS, Joseph, D. ,  GURFINKEL, Jonathan ,  HOLLEY, Dave ,  HUCKABY, Steven, E. ,  KLAUSING, Thomas, A. ,  LAUDO, John, S. ,  SADESKI, Kevin ,  SCHAEFER, Jason, A. ,  SCOTT, K., Bryan ,  STILLMAN, Carol ,  TALBERT, Sherwood ,  TALLARICO, John

IPC: C12Q1/04 ,  G01N33/49

CPC classification number: G01N33/493 ,  C12Q1/04 ,  G01N21/0303 ,  G01N35/025 ,  G01N35/04 ,  G01N2021/6482 ,  G01N2035/0436 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0458 ,  G01N2201/0415

Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.