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公开(公告)号：EP3824902A1
公开(公告)日：2021-05-26
申请号：EP20198287.3
申请日：2008-09-26
发明人： LU, Genmin , PHILLIPS, David R. , ANDRE, Patrick , SINHA, Uma
摘要： The present invention relates antidotes to anticoagulants targeting factor Xa.
The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.-
公开(公告)号：EP3078743B1
公开(公告)日：2020-06-24
申请号：EP16167534.3
申请日：2008-09-26
发明人： LU, Genmin , PHILLIPS, David R. , ANDRE, Patrick , SINHA, Uma
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公开(公告)号：EP2861614A1
公开(公告)日：2015-04-22
申请号：EP13732317.6
申请日：2013-06-12
发明人： LU, Genmin , SINHA, Uma
CPC分类号： C07K1/22 , C12N9/6424 , C12N9/6432
摘要： Disclosed herein are methods and kits for purifying a serine protease. The methods entail loading the serine protease to a soybean trypsin inhibitor (STI) based affinity chromatograph, and eluting the serine protease with an elution buffer comprising an agent that disrupts interaction between the STI and the serine protease
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4.发明公开MODULATION OF FACTOR Xa INHIBITOR MEDIATED BLOOD LOSS BY PARTIAL AND TRANSIENT ADMINISTRATION OF ANTIDOTE 审中-公开调节剂FAKTOR-XA-INHIBITOR-VERMITTELTEN BLUTVERLUSTES DURCH PARTIELLE UND TRANSIENTE VERABREICHUNG EINES GEGENMITTELS
公开(公告)号：EP2814503A1
公开(公告)日：2014-12-24
申请号：EP13709603.8
申请日：2013-02-14
发明人： HOLLENBACH, Stanley J. , LU, Genmin , SINHA, Uma
CPC分类号： A61K38/4846 , C12N9/6432 , C12Y304/21006
摘要： The present disclosure provides unit dose formulations and methods to reduce, stop or prevent bleeding in a patient undergoing anticoagulant therapy with a factor Xa inhibitor. The methods entail at least partial neutralization of the factor Xa inhibitors The unit dose formulations and methods of the present disclosure can be effective even after actual bleeding has initiated.
摘要翻译： 本公开提供了用因子Xa抑制剂进行抗凝治疗的患者中减少，停止或预防出血的单位剂量制剂和方法。 该方法需要至少部分中和因子Xa抑制剂。 即使在实际出血已经开始之后，本公开的单位剂量制剂和方法也是有效的。
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公开(公告)号：EP2193196A2
公开(公告)日：2010-06-09
申请号：EP08834136.7
申请日：2008-09-26
发明人： LU, Genmin , PHILLIPS, David R. , ANDRE, Patrick , SINHA, Uma
CPC分类号： A61K38/4846 , A61K38/00 , A61K38/4826 , A61K38/4833 , A61K38/4853 , A61K39/00 , A61K47/60 , C07K14/435 , C12N9/6432 , C12Y304/21006
摘要： The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
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公开(公告)号：EP2948168B1
公开(公告)日：2018-07-18
申请号：EP13712086.1
申请日：2013-03-13
发明人： LU, Genmin , SINHA, Uma , KARBARZ, Mark , PANDEY, Anjali , CONLEY, Pamela, B.
IPC分类号： A61K38/48 , A61K47/51 , C07K14/745 , C12N9/64
CPC分类号： A61K38/37 , A61K38/4846 , A61K45/06 , A61K47/50 , C12N9/6432 , C12Y304/21006 , A61K2300/00
摘要： The present disclosure relates to compositions and methods for the treatment of bleeding disorders, such as hemophilia A, hemophilia B, von Willebrand (vWF) disease, and factor XII deficiency, by reducing the circulating concentration of tissue factor pathway inhibitor (TFPI), with a factor Xa derivative.
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7.发明授权ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME IN COMBINATION WITH BLOOD COAGULATING AGENTS 有权用于因子XA抑制剂的抗体及其与血液凝结剂组合使用的方法
公开(公告)号：EP2364165B1
公开(公告)日：2018-01-03
申请号：EP09756209.4
申请日：2009-11-11
发明人： LU, Genmin , SINHA, Uma
CPC分类号： A61K38/36 , A61K35/16 , A61K38/16 , A61K38/37 , A61K38/482 , A61K38/4826 , A61K38/4833 , A61K38/4846 , A61K38/4853 , A61K45/06 , A61K2300/00
摘要： The present invention relates to antidotes of anticoagulants targeting factor Xa which antidotes are used in combination with blood coagulating agents or other heparin antidotes to prevent or reduce bleeding in a subject. The antidotes described herein have reduced or no intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is or will be undergoing anticoagulant therapy with a factor Xa inhibitor.
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公开(公告)号：EP2414517B1
公开(公告)日：2016-09-21
申请号：EP10723842.0
申请日：2010-03-29
发明人： SINHA, Uma , LU, Genmin , CONLEY, Pamela B.
CPC分类号： C12N9/6432 , A61K38/482 , A61K38/4826 , A61K38/4833 , A61K38/4846 , A61K38/4853 , A61K39/00 , A61K47/60 , C12Y304/21006
摘要： The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of reversing anticoagulation, stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
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9.发明授权UNIT DOSE FORMULATION OF ANTIDOTE FOR FACTOR XA INHIBITORS FOR USE IN PREVENTING BLEEDING 有权EINZELDOSISFORMULIERUNG VON ANTIDOTENFÜRFAKTOR-XA-HEMMER ZUR PRURVENTION VON BLUTUNG
公开(公告)号：EP2453910B1
公开(公告)日：2016-08-31
申请号：EP10737699.8
申请日：2010-07-14
CPC分类号： A61K38/4846 , A61K9/0019 , C12N9/6432 , C12Y304/21006
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10.发明授权COMBINATION THERAPY WITH A COMPOUND ACTING AS A PLATELET ADP RECEPTOR INHIBITOR 有权与化合物作为血小板ADP受体抑制剂联合治疗
公开(公告)号：EP2146705B1
公开(公告)日：2014-03-05
申请号：EP08747590.1
申请日：2008-05-02
发明人： CONLEY, Pamela B. , ANDRE, Patrick , SINHA, Uma
IPC分类号： A61K31/235 , A61K31/422 , A61K31/435 , A61K31/517 , A61K38/10 , A61K45/06 , A61P7/02 , A61P7/00 , A61K31/44 , A61K31/5377 , A61K31/496 , A61K31/4439 , A61K31/445 , A61K31/40
CPC分类号： A61K31/422 , A61K31/235 , A61K31/435 , A61K31/4545 , A61K31/517 , A61K38/4846 , A61K45/06 , A61K2300/00
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