利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.012 秒)

    DRUG DELIVERY CONJUGATE CAPABLE OF CONTROLLED RELEASE, AND USE THEREOF
    1.
    发明公开
    DRUG DELIVERY CONJUGATE CAPABLE OF CONTROLLED RELEASE, AND USE THEREOF 审中-公开
    能够控制释放的药物递送共轭物及其用途

    公开(公告)号：EP2826492A1

    公开(公告)日：2015-01-21

    申请号：EP13761996.1

    申请日：2013-03-12

    申请人： Postech Academy-Industry Foundation ,  Kyungpook National University Industry-Academic Cooperation Foundation

    发明人： KIM, Won Jong ,  NAMGUNG, Ran ,  LEE, Byung Heon ,  KIM, In San ,  HOFFMAN, Allan

    IPC分类号： A61K47/40 ,  A61K47/48 ,  A61K47/30 ,  A61K31/337

    CPC分类号： A61K31/337 ,  A61K9/0019 ,  A61K9/5161 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6951 ,  B82Y5/00

    摘要： The present invention relates to a hydrophobic drug delivery conjugate, to which cyclodextrin, poly(maleic anhydride), and a hydrophobic drug are bonded, and to a pharmaceutical composition comprising the hydrophobic drug delivery conjugate as an active ingredient. The hydrophobic drug delivery conjugate according to the present invention can effectively control the release rate and the delivery rate of a hydrophobic drug by regulating the physicochemical bonding and/or composition of the cyclodextrin, poly(maleic anhydride), and hydrophobic drug, and can also increase the effect of the drug by significantly increasing the solubility of the hydrophobic drug. Further, the present invention can enable the type of the hydrophobic drug to be varied, as well as a peptide having target directivity to be introduced into a surface of the conjugate, such that the present invention can be applied to the treatment of various diseases in addition to cancer treatment.

    摘要翻译： 本发明涉及与环糊精，聚（马来酸酐）和疏水性药物结合的疏水性药物递送缀合物，以及包含疏水性药物递送缀合物作为活性成分的药物组合物。 根据本发明的疏水性药物递送缀合物可以通过调节环糊精，聚（马来酸酐）和疏水性药物的物理化学键和/或组成来有效控制疏水性药物的释放速率和递送速率，并且还可以 通过显着增加疏水性药物的溶解度来增加药物的作用。 此外，本发明能够改变疏水性药物的类型以及将具有靶向性的肽引入缀合物的表面，使得本发明可以用于治疗 除了癌症治疗。