公开(公告)号：EP1350029B1

公开(公告)日：2014-09-10

申请号：EP02705689.4

申请日：2002-01-08

申请人： President and Fellows of Harvard College

发明人： JEON, Noo Li ,  CHIU, Daniel T. ,  WARGO, Christopher J. ,  CHOI, Insung S. ,  WU, Hongkai ,  ANDERSON, Janelle R. ,  WHITESIDES, George M. ,  MCDONALD, J. Cooper ,  METALLO, Steven J. ,  STONE, Howard A.

IPC分类号： F04B39/10 ,  B01L3/00 ,  B81B1/00

CPC分类号： B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0487 ,  B01L2400/0611 ,  B01L2400/0638 ,  B01L2400/0677 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0007 ,  F16K99/0015 ,  F16K99/003 ,  F16K99/0034 ,  F16K99/0048 ,  F16K99/0057 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/0084 ,  F16K2099/0086 ,  F16K2099/0094 ,  Y10T137/0497 ,  Y10T137/7891 ,  Y10T137/7895 ,  Y10T137/791 ,  Y10T137/87917

公开(公告)号：EP1350029A2

公开(公告)日：2003-10-08

申请号：EP02705689.4

申请日：2002-01-08

申请人： President And Fellows of Harvard College

发明人： JEON, Noo Li ,  CHIU, Daniel T. ,  WARGO, Christopher J. ,  CHOI, Insung S. ,  WU, Hongkai ,  ANDERSON, Janelle R. ,  WHITESIDES, George M. ,  MCDONALD, J. Cooper ,  METALLO, Steven J. ,  STONE, Howard A.

IPC分类号： F04B39/10

CPC分类号： B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0487 ,  B01L2400/0611 ,  B01L2400/0638 ,  B01L2400/0677 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0007 ,  F16K99/0015 ,  F16K99/003 ,  F16K99/0034 ,  F16K99/0048 ,  F16K99/0057 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/0084 ,  F16K2099/0086 ,  F16K2099/0094 ,  Y10T137/0497 ,  Y10T137/7891 ,  Y10T137/7895 ,  Y10T137/791 ,  Y10T137/87917

摘要： The present invention relates to microfluidic systems, including valves (12) and pumps for microfluidic systems. The valves of the invention include check valves (30) such as diaphragm valves and flap valves. Other valves of the invention include one-use valves (12). The pumps of the present invention include a reservoir (40) and at least two check valves (30, 31). The reservoir (40) may be a variable volume. The present invention also relates to a flexible microfluidic system (10). The present invention additionally relates to a method of making microfluidic systems (10) including those of the present invention. The method includes forming a microfluidic system on a master (100), connecting a support (110) to the microfluidic system (10) and removing the microfluidic system (10) from the master (100). The support (110) may remain connected to the microfluidic system (10) or the microfluidic system (10) may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system. This method includes initiating fluid flow in a first direction (50) and inhibiting fluid flow in a second direction (50) and may be practiced with the valves (12) of the present invention.

公开(公告)号：EP1331996A1

公开(公告)日：2003-08-06

申请号：EP01981806.1

申请日：2001-09-18

申请人： President And Fellows of Harvard College

发明人： JEON, Noo Li ,  DERTINGER, Stephan, K.W. ,  CHIU, Daniel, T. ,  CHOI, Insung, S. ,  WHITESIDES, George, M.

IPC分类号： B01L1/00

CPC分类号： B01F5/0601 ,  B01F5/064 ,  B01F13/0059 ,  B01F15/0404 ,  B01J4/001 ,  B01J19/0093 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01L3/5027 ,  G01N1/2813 ,  G01N1/38

摘要： A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the same streams may possess different properties. The separate streams may be combined to produce a gradient, such as a concentration gradient or shear gradient. The apparatus of the invention may provide a network of fluidic channels that may be used to manipulate a fluid to produce, for example, a gradient or a series of solutions containing a substance at varying concentrations.

摘要翻译： 一种用于处理流体的方法和装置。 用于处理流体的方法可以包括将两个或多个分离的流合并成共同物流，然后将共同物流分成新的一组独立的流，其中分离的流可以具有不同的性质。 可以将单独的流组合以产生梯度，例如浓度梯度或剪切梯度。 本发明的装置可以提供流体通道网络，其可用于操纵流体以产生例如含有不同浓度物质的梯度或一系列溶液。