利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

508 records (took 0.035 seconds)

    STERILIZABLE PHOTOPOLYMER SERUM SEPARATOR
    1.
    发明授权
    STERILIZABLE PHOTOPOLYMER SERUM SEPARATOR 有权
    可灭菌的光聚合物血清分离器

    公开(公告)号：EP2909301B1

    公开(公告)日：2018-03-07

    申请号：EP13849758.1

    申请日：2013-10-10

    Applicant: The Regents of the University of California ,  University Of Maryland

    Inventor： EMERSON, Jane, F. ,  AL-SHEIKHLY, Mohamad

    IPC: B01L3/00

    CPC classification number: B01L3/50215 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2400/0677 ,  G01N33/491

    Abstract: Sterilizable separator tubes and methods of utilization of same are presented. Methods include providing a separator tube containing a separator substance that can be polymerized to a desired hardness following sterilization using radical generating radiation. The separator substance is formulated to have a density between that of the average densities of separable fractions derived from a sample fluid such as blood, and to be flowable. Upon centrifugation of a separator tube containing a fluid sample, the separator substance forms a barrier between the fractions. The barrier subsequently hardens to form a solid barrier when triggered by a suitable energy source.

    SYSTEMS AND METHODS FOR DETECTION AND QUANTIFICATION OF ANALYTES
    2.
    发明公开
    SYSTEMS AND METHODS FOR DETECTION AND QUANTIFICATION OF ANALYTES 审中-公开
    用于检测和定量分析的系统和方法

    公开(公告)号：EP3191849A1

    公开(公告)日：2017-07-19

    申请号：EP15771337.1

    申请日：2015-09-10

    Applicant: CUE INC.

    Inventor： KHATTAK, Ayub ,  SEVER, Clinton

    IPC: G01N35/00 ,  B01L3/00

    CPC classification number: G01N35/00871 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/141 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0887 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0677 ,  G01N35/00029 ,  G01N35/1095 ,  G01N2035/0091

    Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

    Abstract translation: 本文描述了用于检测收集的样品内的感兴趣分子的装置，系统和方法。 在某些实施例中，公开了独立式样本分析系统，其包括可重复使用的读取器组件，一次性盒组件和一次性样本收集组件。 在一些实施例中，读取器组件与远程计算设备进行通信以用于测试协议和测试结果的数字传输。 在各种公开的实施方案中，系统，组分和方法被配置为鉴定特定核酸，蛋白质或其他感兴趣分析物的存在，不存在和/或数量，例如以便测试一种 或更多样本中的病原体或污染物。

    APPARATUS AND METHOD FOR TESTING MULTI-FUNCTION AND DRUG RESPONSE OF CENTRIFUGAL MICROFLUIDICS-BASED PLATELETS
    3.
    发明公开
    APPARATUS AND METHOD FOR TESTING MULTI-FUNCTION AND DRUG RESPONSE OF CENTRIFUGAL MICROFLUIDICS-BASED PLATELETS 审中-公开
    DEVICE AND METHOD FOR MULTI功能和药物对ADDRESS离心MICROFLUIDICS基于滑动试验

    公开(公告)号：EP2940470A4

    公开(公告)日：2017-03-29

    申请号：EP13868176

    申请日：2013-12-27

    Applicant: UNIV KOREA RES & BUS FOUND

    Inventor： SHIN SE HYUN ,  LIM CHAE SEUNG ,  NAM JEONG HOON ,  LIM HYUN JUNG

    IPC: G01N33/49 ,  B01F13/00 ,  B01F13/08 ,  B01F15/02 ,  B01L3/00 ,  G01N33/15 ,  G01N33/50 ,  G01N35/00 ,  G01N35/08

    CPC classification number: G01N33/5029 ,  B01F13/0059 ,  B01F13/0818 ,  B01F15/0233 ,  B01L3/502746 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0409 ,  B01L2400/0677 ,  G01N33/491 ,  G01N33/5044 ,  G01N35/00069 ,  G01N2035/00237

    Abstract: The present invention relates to an apparatus and method for testing a multi-function and a drug response of platelet based on a centrifugal microfluidics. The testing apparatus according to the present invention may include: a rotatable disk; a sample chamber arranged at the center of the disk such that a blood sample is accommodated therein; stirring chambers respectively connected to the sample chamber in multiple radial directions so as to introduce a shear flow in the blood sample; microchannels connected to the stirring chambers such that adhesion and cohesion of platelets occur during the 44 movement of the blood sample; and a waste sample chamber in which the blood sample is accommodated after passing through the microchannels. According to the present invention, multiple drug tests can be performed on a single blood sample at one time in multiple channels such that multiple tests is possible with respect to complex platelet functions, and thus testing time is reduced and testing costs can be saved.

    Abstract translation: 本发明涉及的装置和方法用于测试多功能和基于离心微流体血小板的药物响应。 的测试设备gemäß到，本发明可以包括：可旋转的基盘; 在盘搜索的中心布置在样品腔室没有血液样品容纳在其中; 搅拌分别连接到在多个径向方向上的样品室，以便引入血液样品中的剪切流动腔; 微通道连接到搅拌室搜索血液样品的44运动期间没有粘附和血小板的凝聚进行; 和废液样品室，其中所述血液样品通过微通道后容纳。 。根据本发明，多种药物测试可以在单个血液样品在同一时间在多个频道执行搜索并多次测试是可能相对于复杂的血小板功能，因而测试时间减少和测试成本可以被保存。

    Instruments and method for exposing a receptacle to multiple thermal zones
    6.
    发明授权
    Instruments and method for exposing a receptacle to multiple thermal zones 有权
    仪器和Verfahren zur Aussetzung einesBehälterszu mehrerenWärmezonen

    公开(公告)号：EP2425894B1

    公开(公告)日：2016-12-28

    申请号：EP11185728.0

    申请日：2008-06-20

    Applicant: Gen-Probe Incorporated ,  Qualigen, Inc.

    Inventor： Breidenthal, Scott ,  Fan, Sara ,  Lee, Richard ,  Nelson, Norman ,  Scott, Matthew ,  Taylor, Jason ,  Poirier, Michael

    IPC: B01L3/00 ,  G01N35/00 ,  B01F11/00

    CPC classification number: B01F11/00 ,  B01F3/1271 ,  B01F11/0045 ,  B01F11/0071 ,  B01F13/0059 ,  B01F15/00214 ,  B01F2215/0037 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/0621 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1883 ,  B01L2400/0457 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/0677 ,  C12N15/1006 ,  C12Q1/6806 ,  C12Q1/6844 ,  G01N1/44 ,  G01N21/01 ,  G01N21/6428 ,  G01N21/645 ,  G01N35/0098 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2035/00544 ,  G01N2201/0627 ,  Y10T137/0391 ,  Y10T436/143333 ,  Y10T436/25 ,  Y10T436/255

    Abstract: A detector for detecting an optical signal from a sample that may be indicative of the presence, amount, or state of one or more analytes in the sample, the detector comprising: one or more excitation channels, each disposed within one of the conduits of the housing and adapted to direct an excitation signal of a prescribed excitation wavelength or range of excitation wavelengths toward the sample, and each excitation channel comprising: a light emitting element adapted to emit excitation light; and excitation optical elements defining an excitation optical path having an excitation optic axis, the excitation optical elements comprising a lens and an excitation filter constructed and arranged to transmit only light emitted by the light emitting element having the prescribed excitation wavelength or range of excitation wavelengths toward the sample, one or more emissions channels, each disposed within one of the conduits of the housing and adapted to receive an emission signal from the sample and detect an emission signal having a prescribed emission wavelength or range of emission wavelengths, and each emission channel comprising: emission optical elements defining an emission optical path having an emission optic axis, the emission optical elements comprising a lens and an emission filter constructed and arranged to transmit only light emitted by the sample having the prescribed emission wavelength or range of emission wavelengths; and a light-detecting element adapted to detect light transmitted by the emission optical elements and to convert the detected light to an electronic signal indicative of at least one of the presence and strength of the detected light, a housing, wherein each of the excitation and emission channels is disposed within a different conduit defined within the housing; wherein the excitation and emission optic axes are parallel to one another throughout their extents; and an optic lens constructed and arranged with respect to the excitation and emission channels to (1) direct excitation light transmitted by each excitation channel and impinging on a different portion of the optic lens at a prescribed location and (2) receive emission signals emitted by the sample at the prescribed location and to direct at least a portion of the received emission signals into each emission channel.

    Abstract translation: 一种用于检测来自样品的光信号的检测器，其可以指示样品中一种或多种分析物的存在，量或状态，所述检测器包括：一个或多个激发通道，每个激发通道设置在所述样品的一个管道内 并且适于将规定的激发波长或激发波长范围的激励信号引导到样品，并且每个激励通道包括：适于发射激发光的发光元件; 激励光学元件限定具有激发光轴的激发光路，所述激发光学元件包括透镜和激励滤光器，所述激发光学元件被构造和布置成仅发射具有规定的激发波长或激发波长范围的发光元件发射的光，朝向 所述样品，一个或多个排放通道，每个排放通道均设置在所述壳体的一个管道内，并且适于接收来自所述样品的发射信号，并且检测具有规定的发射波长或发射波长范围的发射信号，并且每个发射通道包括 限定具有发射光轴的发射光路的发射光学元件，所述发射光学元件包括透镜和发射滤光器，所述发射滤光器构造和布置成仅透射由具有规定发射波长或发射波长范围的样品发射的光; 以及光检测元件，其适于检测由所述发射光学元件发射的光并且将检测到的光转换为指示所检测到的光的存在和强度中的至少一个的电子信号，壳体，其中所述激发和 排放通道设置在限定在壳体内的不同导管内; 其中所述激发和发射光轴在其整个范围内彼此平行; 以及相对于激发和发射通道构造和布置的光学透镜，以（1）直接由每个激发通道传输的激发光并且在预定位置处照射在光学透镜的不同部分上，以及（2）接收由 在规定位置处的采样并且将接收到的发射信号的至少一部分引导到每个发射通道中。

    Fluidkanalsystem zur Untersuchung von Zellen
    8.
    发明公开
    Fluidkanalsystem zur Untersuchung von Zellen 审中-公开
    用于细胞研究流体通道系统

    公开(公告)号：EP3020480A1

    公开(公告)日：2016-05-18

    申请号：EP14193245.9

    申请日：2014-11-14

    Applicant: ibidi GmbH

    Inventor： Zantl, Roman ,  Dietrich, Miriam

    IPC: B01L3/00

    CPC classification number: G01N33/5029 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/16 ,  B01L2400/0672 ,  B01L2400/0677 ,  G03F7/30

    Abstract: Die vorliegende Erfindung betrifft ein Fluidkanalsystem zur Untersuchung von Zellen, umfassend eine Kammer, die mit mindestens einem fotopolymerisierten Hydrogel und/oder einem polymerisierten fotodepolymerisierbaren Hydrogel zu mindestens 90%, insbesondere vollständig, gefüllt ist. Dabei ist die Kammer über mindestens zwei Öffnungen ausschließlich zu mindestens einem Fluidkanal hin offen, wobei der mindestens eine Fluidkanal und die Kammer jeweils in Form eines Hohlraums in einem Substrat ausgebbildet sind und wobei jeder Fluidkanal zwei Öffnungen nach außen aufweist.
    Die vorliegende Erfindung betrifft außerdem ein Fluidkanalsystem zur Untersuchung von Zellen, umfassend einen Hohlraum in einem Substrat, wobei in dem Hohlraum mindestens ein fotopolymerisiertes Hydrogel und/oder ein polymerisiertes fotodepolymerisierbares Hydrogel angeordnet ist, das derart strukturiert ist, dass mindestens ein Fluidkanal und eine zusammenhängende Hydrogelstruktur ausgebildet sind, wobei die Hydrogelstruktur an zwei getrennten Oberflächenbereichen an den mindestens einen Fluidkanal angrenzt und ausschließlich über den mindestens einen Fluidkanal eine Verbindung nach außen hat.

    Abstract translation: 本发明涉及一种用于细胞的研究的流体通道系统，包括其完全充满至少一种光聚合的水凝胶和/或聚合的水凝胶fotodepolymerisierbaren至少90％，特别是腔室中。 该腔室是仅用于至少一个流体通道打开的至少两个开口，其中所述至少一个流体通道和腔室被ausgebbildet每个在衬底中的腔的形式，并且其中，每个流体通道具有两个开口到外部。 本发明还涉及用于细胞的研究的流体通道系统，其包括在衬底中的空腔，其中至少一个光聚合的水凝胶和/或聚合的fotodepolymerisierbares水凝胶设置在所述腔中，其被构造成使得至少一个流体通道和一个连贯的水凝胶 形成，该水凝胶结构是邻近于所述至少一个流体通道两个分开的表面区域，并且具有只通过所述至少一个流体通道与外部连通。

Patent Agency Ranking