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公开(公告)号：EP4268832A2
公开(公告)日：2023-11-01
申请号：EP23189053.4
申请日：2019-03-27
发明人： YU, Yi-Tao , ADACHI, Hironori , ZOYSA, Meemanage De , TURUNEN, Janne Juha , KLEIN, Bart , VAN SINT FIET, Lenka , BOUDET, Julien Auguste Germain , DA SILVA, Pedro Duarte Morais Fernandes Arantes
IPC分类号： A61K31/713
摘要： The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.
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公开(公告)号：EP3947679A1
公开(公告)日：2022-02-09
申请号：EP20719950.6
申请日：2020-04-02
发明人： TURUNEN, Janne Juha , KLEIN, Bart , VAN SINT FIET, Lenka , AALTO, Antti , KEMMEL, Cherie Paige , HOOGEBOOM, Tess , VAN WISSEN, Lisanne Alieda
IPC分类号： C12N15/113 , C12N15/11 , A61K31/7125
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公开(公告)号：EP4185695A1
公开(公告)日：2023-05-31
申请号：EP21754932.8
申请日：2021-07-22
IPC分类号： C12N15/113 , C12N15/11
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公开(公告)号：EP3507366A1
公开(公告)日：2019-07-10
申请号：EP17771348.4
申请日：2017-08-31
发明人： TURUNEN, Janne Juha , AALTO, Antti , KLEIN, Bart , VAN SINT FIET, Lenka , BOUDET, Julien Auguste Germain
IPC分类号： C12N15/113 , C12N15/10 , A61K31/712
摘要： The invention relates to antisense oligonucleotides that are capable of bringing about specific editing of a target nucleotide (adenosine) in a target RNA sequence in a eukaryotic cell, wherein said oligonucleotide does not, in itself, form an intramolecular hairpin or stem-loop structure, and wherein said oligonucleotide comprises a non-complementary nucleotide in a position opposite to the nucleotide to be edited in the target RNA sequence.
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公开(公告)号：EP3775210A2
公开(公告)日：2021-02-17
申请号：EP19716731.5
申请日：2019-03-27
发明人： KLEIN, Bart , TURUNEN, Janne, Juha , VAN SINT FIET, Lenka , DA SILVA, Pedro Duarte Morais Fernandes, Arantes , BOUDET, Julien Auguste, Germain , YU, Yi-Tao , ADACHI, Hironori , ZOYSA, Meemanage De
IPC分类号： C12N15/113 , C12N15/10 , A61K31/713 , C12N5/10
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公开(公告)号：EP3475424A1
公开(公告)日：2019-05-01
申请号：EP17733425.7
申请日：2017-06-22
发明人： TURUNEN, Janne Juha , DE BRUIJN, Petra Geziena , KLEIN, Bart , REDIS, Roxana Simona , VAN SINT FIET, Lenka
IPC分类号： C12N15/11
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公开(公告)号：EP4268832A3
公开(公告)日：2024-03-06
申请号：EP23189053.4
申请日：2019-03-27
发明人： YU, Yi-Tao , ADACHI, Hironori , ZOYSA, Meemanage De , TURUNEN, Janne Juha , KLEIN, Bart , VAN SINT FIET, Lenka , BOUDET, Julien Auguste Germain , DA SILVA, Pedro Duarte Morais Fernandes Arantes
IPC分类号： C12N15/113 , C12N15/10 , A61K31/713 , C12N5/10
摘要： The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.
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8.发明公开
公开(公告)号：EP4081638A1
公开(公告)日：2022-11-02
申请号：EP20839095.5
申请日：2020-12-23
IPC分类号： C12N15/113 , A61K48/00 , A61K31/7125 , A61K38/50 , A61P27/02
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公开(公告)号：EP3983546A1
公开(公告)日：2022-04-20
申请号：EP20737070.1
申请日：2020-06-12
发明人： TURUNEN, Janne, Juha , VAN SINT FIET, Lenka , KEMMEL, Cherie, Paige , BEAL, Peter , DOHERTY, Erin, E.
IPC分类号： C12N15/113 , A61K31/7115
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公开(公告)号：EP3959316A1
公开(公告)日：2022-03-02
申请号：EP20721451.1
申请日：2020-04-09
IPC分类号： C12N15/113 , C12N15/11 , A61K31/7125
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