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1.发明公开METHOD FOR EVALUATING COAGULATION ABILITY OF BLOOD SPECIMEN, AND REAGENT, REAGENT KIT AND DEVICE TO BE USED THEREIN 审中-公开评估血液样本的凝结能力的方法，以及试剂盒和在其中使用的装置
公开(公告)号：EP3287791A1
公开(公告)日：2018-02-28
申请号：EP16782966.2
申请日：2016-03-30
申请人： Public University Corporation Nara Medical University , Chugai Seiyaku Kabushiki Kaisha , Sysmex Corporation
发明人： SHIMA, Midori , NOGAMI, Keiji , MATSUMOTO, Tomoko , KITAZAWA, Takehisa , SOEDA, Tetsuhiro , IKEDA, Yuka
CPC分类号： G01N33/4905 , B01L3/00 , C12Q1/56 , G01N21/51 , G01N21/59 , G01N33/86 , G01N2201/122
摘要： The present invention relates to a method for evaluating coagulability of a blood specimen obtained from a subject to whom a substance having a coagulation factor VIII-substituting activity is administered. The present invention also relates to a reagent for blood coagulation analysis, a reagent kit for blood coagulation analysis, and an apparatus for blood coagulation analysis. Furthermore, the present invention relates to an apparatus and computer program for evaluating coagulability of a blood specimen.
摘要翻译： 本发明涉及一种用于评估从施用具有凝固因子VIII取代活性的物质的对象获得的血液样本的凝固性的方法。 本发明还涉及用于凝血分析的试剂，用于凝血分析的试剂盒以及用于凝血分析的设备。 此外，本发明涉及用于评估血液样本的凝固性的装置和计算机程序。
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公开(公告)号：EP3603670A1
公开(公告)日：2020-02-05
申请号：EP18776553.2
申请日：2018-03-30
发明人： SHIMA, Midori , NOGAMI, Keiji , OGIWARA, Kenichi
摘要： The present inventors examined the procoagulant activity of a multispecific antigen-binding molecule that functionally substitutes for FVIII using blood and plasma derived from FIX disorder patients. The result showed that multispecific antigen-binding molecules that functionally substitute for FVIII can be used not only as methods for preventing and/or treating bleeding in hemophilia A, acquired hemophilia A, von Willebrand disease, and hemophilia C, which are caused by FVIII dysfunction, but also as methods for preventing and/or treating bleeding in FIX disorders, because of their procoagulant activity. Furthermore, the effect of a FIX formulation could be enhanced by using it in combination with a multispecific antigen-binding molecule that functionally substitutes for FVIII, and it was shown that the combined use is promising as a combination therapy that shows stable hemostatic effects.
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3.发明公开METHOD FOR EVALUATING BLOOD COAGULATION REACTION 有权VERFAHREN ZUR BEURTEILUNG DER BLUTGERINNUNGSREAKTION
公开(公告)号：EP2902787A1
公开(公告)日：2015-08-05
申请号：EP13842222.5
申请日：2013-09-26
IPC分类号： G01N33/86
CPC分类号： C12Q1/56 , C12N9/6443 , G01N33/86 , G01N2333/755 , G01N2333/96452 , G01N2800/224
摘要： Various methods for evaluating hemostatic effect and various blood coagulation initiation reagents were studied to construct a method for evaluating blood coagulation reaction mediated by a substance having an activity of substituting for coagulation factor VIII (FVIII). As a result, it was discovered that by using a coagulation initiation reagent containing activated coagulation factor XI (FXIa) and phospholipids, the effect of a substance having an activity of substituting for coagulation factor VIII (FVIII) on blood coagulation reaction can be evaluated using the amount of thrombin generated in the blood sample as an indicator.
摘要翻译： 研究了各种评价止血效果的方法和各种血液凝固引发剂，构建了用具有代替凝血因子VIII（FVIII）的物质介导的血液凝固反应的评价方法。 结果发现，通过使用含有活化凝血因子XI（FXIa）和磷脂的凝血引发剂，可以使用具有代替凝血因子VIII（FVIII）的活性的物质对血液凝固反应的作用，使用 在血液样本中产生的凝血酶量作为指标。
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公开(公告)号：EP2902787B1
公开(公告)日：2018-03-28
申请号：EP13842222.5
申请日：2013-09-26
CPC分类号： C12Q1/56 , C12N9/6443 , G01N33/86 , G01N2333/755 , G01N2333/96452 , G01N2800/224
摘要： Various methods for evaluating hemostatic effect and various blood coagulation initiation reagents were studied to construct a method for evaluating blood coagulation reaction mediated by a substance having an activity of substituting for coagulation factor VIII (FVIII). As a result, it was discovered that by using a coagulation initiation reagent containing activated coagulation factor XI (FXIa) and phospholipids, the effect of a substance having an activity of substituting for coagulation factor VIII (FVIII) on blood coagulation reaction can be evaluated using the amount of thrombin generated in the blood sample as an indicator.
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公开(公告)号：EP3199952A1
公开(公告)日：2017-08-02
申请号：EP15843728.5
申请日：2015-09-24
CPC分类号： G01N33/86 , C07K16/36 , C07K2317/31 , G01N2333/755 , G01N2333/96444 , G01N2333/9645 , G01N2800/224 , G01N2800/52 , G01N2800/56
摘要： The inventors produced substances that neutralize the activity of a bispecific antibody having an activity of functionally substituting for FVIII, and undertook the construction of methods for measuring the reactivity of FVIII that can ensure accuracy even in the presence of this bispecific antibody. As a result, the inventors discovered that in APTT-based one-stage clotting assay, FVIII activity in the plasma of a hemophilia A patient can be evaluated accurately, and also that in APTT-based Bethesda assay, FVIII inhibitor titer in the plasma of a hemophilia A patient carrying a FVIII inhibitor can be evaluated accurately.
摘要翻译： 本发明人制备了中和具有功能性取代FVIII活性的双特异性抗体的活性的物质，并且进行了测量即使在该双特异性抗体存在下也可以确保准确性的FVIII反应性的方法的构建。 结果，本发明人发现，在基于APTT的一步凝固测定中，可以精确评估血友病A患者血浆中的FVIII活性，并且在基于APTT的Bethesda测定中，可以准确评估血浆中的FVIII抑制剂滴度 可以准确地评估携带FVIII抑制剂的血友病患者A.
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公开(公告)号：EP3961211A1
公开(公告)日：2022-03-02
申请号：EP20795805.9
申请日：2020-04-23
发明人： KAWABE, Toshiki , ODA, Yukio , EMMI, Mari , SHIMA, Midori , NOGAMI, Keiji , OGIWARA, Kenichi , SHIMONISHI, Naruto
摘要： Provided is a method by which a titer of a coagulation factor inhibitor can be measured simply and in a short time. The present invention relates to a method for measuring a titer of a coagulation factor inhibitor. The method includes: preparing a mixed specimen containing a subject blood specimen and a normal blood specimen; heating the mixed specimen and acquiring a coagulation reaction curve for the heated mixed specimen; acquiring a coagulation reaction curve for the mixed specimen that has not been heated; calculating a parameter related to the coagulation reaction curve of the mixed specimen that has not been heated as a first parameter; calculating a parameter related to the coagulation reaction curve of the heated mixed specimen as a second parameter; and calculating a titer of a coagulation factor inhibitor in the subject blood specimen on the basis of the ratio or the difference between the first parameter and the second parameter.
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公开(公告)号：EP3988933A1
公开(公告)日：2022-04-27
申请号：EP20827280.7
申请日：2020-06-19
发明人： KAWABE, Toshiki , ODA, Yukio , SHIMA, Midori , NOGAMI, Keiji , OGIWARA, Kenichi , SHIMONISHI, Naruto
摘要： Provided is an APTT prolongation factor estimation system. The APTT prolongation factor estimation system includes: one or more facilities each including an analyzer which measures a blood coagulation reaction of a subject blood specimen; a database which stores data on a blood coagulation reaction and APTT prolongation factor of blood specimens; and a computer which estimates an APTT prolongation factor of the subject blood specimen based on data on the blood coagulation reaction from the analyzer and the data stored in the database. The facilities each further includes: a data transmission unit which transmits, to the computer, the data on the blood coagulation reaction of the subject blood specimen obtained by the analyzer; and a data reception unit which receives a result of the estimation of the APTT prolongation factor, which is obtained by the computer, regarding the subject blood specimen measured by each of the analyzers.
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公开(公告)号：EP3919913A1
公开(公告)日：2021-12-08
申请号：EP20749235.6
申请日：2020-01-31
发明人： KAWABE, Toshiki , ODA, Yukio , SHIMA, Midori , NOGAMI, Keiji , OGIWARA, Kenichi
IPC分类号： G01N33/86
摘要： To provide a method for analyzing coagulation characteristics of a blood specimen. To provide a method for analyzing a blood specimen, including: acquiring a waveform related to a coagulation rate or coagulation acceleration of a sample obtained by mixing a subject blood specimen with a reagent for measuring coagulation time; extracting multiple parameters characterizing the waveform related to a coagulation rate or a coagulation acceleration; and determining an activity level or activity abnormality of a coagulation factor in the subject blood specimen on the basis of the multiple parameters.
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