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    Derivatives of thioformamide
    1.
    发明公开
    Derivatives of thioformamide 失效
    Thioformamidderivate。

    公开(公告)号：EP0321274A1

    公开(公告)日：1989-06-21

    申请号：EP88311927.3

    申请日：1988-12-16

    申请人： RHONE POULENC RORER LIMITED

    发明人： Cook, David Charles ,  Hart, Terance William ,  McLay, Iain McFarlane ,  Palfreyman, Malcolm Norman ,  Walsh, Roger John Aitchison

    IPC分类号： C07D213/59 ,  C07D213/61 ,  C07D215/14 ,  C07D217/16 ,  C07D239/26 ,  C07D401/12 ,  C07D213/50 ,  C07D213/53 ,  C07D215/12 ,  A61K31/44 ,  A61K31/47

    CPC分类号： C07D213/53 ,  C07D213/56 ,  C07D213/61 ,  C07D215/12 ,  C07D215/14 ,  C07D217/14 ,  C07D239/26

    摘要： Therapeutically useful thioformamide derivatives of the formula:
    wherein R represents alkyl, Het represents pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3-b]­pyridin-5-yl, pyrazin-2-yl, indol-3-yl and thieno[3,2-b]­pyridin-6-yl, Y represents ethylene, methylene or a valency bond, and X represents carbonyl, hydroxymethylene, >C=NOR¹, >C=NN(R¹)₂ or >C=NN(R¹)CON(R¹)₂ in which R¹ represents hydrogen or optionally substituted alkyl, benzyl, phenethyl, 1-naphthylmethyl, 2-naphthylmethyl or pyrid-3-ylmethyl, or two R¹ substituents on the same nitrogen atom may together form an optionally substituted alkylene radical chain and salts thereof, processes for their preparation and compositions containing them are described.

    摘要翻译： 治疗上有用的下式的硫代甲酰胺衍生物：其中R代表烷基，Het代表吡啶-3-基，异喹啉-4-基，四氢喹啉-3-基，喹啉-3-基，哒嗪-4-基，嘧啶-4-基， 噻吩并[2,3-b]吡啶-5-基，吡嗪-2-基，吲哚-3-基和噻吩并[3,2-b]吡啶-6-基， Y代表乙烯，亚甲基或价键，X代表羰基，羟基亚甲基，C = NOR 1，C = NN（R 1）2或C = NN（R 1）CON 1）其中R 1表示氢或任选取代的烷基，苄基，苯乙基，1-萘基甲基，2-萘基甲基或吡啶-3-基甲基或同一氮原子上的两个R 1取代基可以一起 形成任选取代的亚烷基自由基链及其盐，其制备方法和含有它们的组合物。