公开(公告)号：EP3833657A1

公开(公告)日：2021-06-16

申请号：EP20749897.3

申请日：2020-07-31

申请人： Advanced Biodesign

发明人： CEYLAN, Ismail ,  MARTIN, Guillaume ,  PEREZ, Mileidys ,  BERROU, Axelle

IPC分类号： C07D213/34 ,  A61K31/4402 ,  A61K31/4406 ,  C07D213/59 ,  C07C327/22 ,  A61K31/4409 ,  A61P35/00 ,  A61K31/255 ,  A61K47/50

公开(公告)号：EP1904471A1

公开(公告)日：2008-04-02

申请号：EP06776122.1

申请日：2006-07-05

申请人： F.HOFFMANN-LA ROCHE AG

发明人： BOYD, Edward ,  BROOKFIELD, Frederick ,  GRIDLEY, Jonathan ,  KUBBIES, Manfred ,  LAU, Raymond ,  REIFF, Ulrike ,  TIEFENTHALER, Georg ,  VON DER SAAL, Wolfgang ,  VON HIRSCHHEYDT, Thomas ,  WOODCOCK, Timothy

IPC分类号： C07D333/24 ,  C07D213/59 ,  A61K31/38 ,  A61P35/00 ,  A61K31/44

CPC分类号： A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  C07D213/59 ,  C07D333/24

摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

公开(公告)号：EP0390694A1

公开(公告)日：1990-10-03

申请号：EP90400869.5

申请日：1990-03-30

申请人： RHONE-POULENC SANTE

发明人： Hart, Terance William ,  Vacher, Bernard Yvon Jack ,  Sharp, Brian William

IPC分类号： C07C327/46 ,  C07D213/59 ,  C07D215/14 ,  C07D217/16 ,  C07D237/08 ,  C07D239/26 ,  C07D241/12 ,  C07D209/18 ,  C07D277/30 ,  A61K31/16 ,  A61K31/33

CPC分类号： C07C327/46 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D213/59

摘要： A thioformamide derivative of the formula I
wherein:-
R and R¹ each independently represent an alkyl group;
A represents either:-

(1) a phenyl group which is optionally substituted; or
(2) a heteroaromatic group (e.g. pyrid-3-yl, quinolin-3-yl); and
Y represents:-
an ethylene or methylene group or a direct bond.
These compounds may be formulated as pharmaceutical preparations and have utility for the treatment of disorders associated with smooth muscle contraction.

摘要翻译： 式I的硫代甲酰胺衍生物，其中：-R和R 1各自独立地代表烷基; A代表： - （1）任选被取代的苯基; 或（2）杂芳族基团（例如吡啶-3-基，喹啉-3-基）; Y表示： - 亚乙基或亚甲基或直接键。 这些化合物可以配制成药物制剂并且可用于治疗与平滑肌收缩相关的病症。

公开(公告)号：EP1904471B1

公开(公告)日：2009-10-21

申请号：EP06776122.1

申请日：2006-07-05

申请人： F.HOFFMANN-LA ROCHE AG

发明人： BOYD, Edward ,  BROOKFIELD, Frederick ,  GRIDLEY, Jonathan ,  KUBBIES, Manfred ,  LAU, Raymond ,  REIFF, Ulrike ,  TIEFENTHALER, Georg ,  VON DER SAAL, Wolfgang ,  VON HIRSCHHEYDT, Thomas ,  WOODCOCK, Timothy

IPC分类号： C07D333/24 ,  C07D213/59 ,  A61K31/38 ,  A61P35/00 ,  A61K31/44

CPC分类号： A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  C07D213/59 ,  C07D333/24

摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

公开(公告)号：EP0321274B1

公开(公告)日：1994-03-30

申请号：EP88311927.3

申请日：1988-12-16

申请人： RHONE-POULENC RORER LIMITED

发明人： Cook, David Charles ,  Hart, Terance William ,  McLay, Iain McFarlane ,  Palfreyman, Malcolm Norman ,  Walsh, Roger John Aitchison

IPC分类号： C07D213/59 ,  C07D213/61 ,  C07D215/14 ,  C07D217/16 ,  C07D239/26 ,  C07D401/12 ,  C07D213/50 ,  C07D213/53 ,  C07D215/12 ,  A61K31/44 ,  A61K31/47

CPC分类号： C07D213/53 ,  C07D213/56 ,  C07D213/61 ,  C07D215/12 ,  C07D215/14 ,  C07D217/14 ,  C07D239/26

公开(公告)号：EP0390693B1

公开(公告)日：1993-08-25

申请号：EP90400868.7

申请日：1990-03-30

申请人： RHONE-POULENC SANTE

发明人： Hart, Terance William ,  Vacher, Bernard Yvon Jack ,  Sharp, Brian William

IPC分类号： C07D213/59 ,  C07D213/80 ,  C07D213/79 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  C07D215/14 ,  A61K31/44 ,  A61K31/47

CPC分类号： C07D213/79 ,  C07D213/59 ,  C07D215/14 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

公开(公告)号：EP0336561B1

公开(公告)日：1993-07-28

申请号：EP89302143.6

申请日：1989-03-03

申请人： SUNTORY LIMITED

发明人： Okitsu, Mitsuhito

IPC分类号： C07D213/59 ,  A61K31/44 ,  C07D213/55

CPC分类号： C07D213/55 ,  C07D213/59

公开(公告)号：EP2668156B1

公开(公告)日：2018-10-31

申请号：EP12701354.8

申请日：2012-01-27

申请人： BASF SE

发明人： KUNIMOTO, Kazuhiko ,  SAMESHIMA, Kaori ,  MATSUOKA, Yuki ,  KURA, Hisatoshi

IPC分类号： C07C309/30 ,  C07C327/58 ,  C07D213/59 ,  C07D265/32 ,  C07D277/54 ,  C07D291/02 ,  C07D327/06 ,  H01L21/027

CPC分类号： G03F7/0007 ,  C07C309/00 ,  C07C309/30 ,  C07C309/67 ,  C07C309/73 ,  C07C327/58 ,  C07C327/60 ,  C07C2601/14 ,  C07C2602/42 ,  C07D213/59 ,  C07D213/78 ,  C07D265/32 ,  C07D277/54 ,  C07D279/12 ,  C07D291/02 ,  C07D295/04 ,  C07D307/10 ,  C07D309/08 ,  C07D327/06 ,  C08F220/10 ,  G02B5/201 ,  G02B5/223 ,  G03F7/027 ,  G03F7/028 ,  G03F7/029 ,  G03F7/031 ,  G03F7/032 ,  G03F7/322

摘要： The present invention relates to a polymerizable composition comprising at least one ethylenically unsaturated, polymerizable compound and at least one oxime sulfonate compound of the formula (I) QAaBbCc where a is 0, 1, 2, 3, 4 or 6, b is 0, 1, 2, 3, 4 or 6, and c is 0, 1, 2, 3, 4 or 6, where the sum of a+b+c is 1, 2, 3, 4 or 6 where (A) is a group (B) is a group (C) is a group where # denotes the point of attachment to Q; X is S or NR14 and Q, R1, R2, R3 and R14 are as defined in claim 1 and in the description. The present invention also relates to the use of the this composition, to novel oxime sulfonates and the use of the oxime sulfonates as thermal curing promoter.

公开(公告)号：EP3186226A1

公开(公告)日：2017-07-05

申请号：EP15835348.2

申请日：2015-08-13

申请人： BASF SE

发明人： KUNIMOTO, Kazuhiko ,  SAMESHIMA, Kaori ,  KURA, Hisatoshi ,  MATSUOKA, Yuki

IPC分类号： C07D213/59 ,  C07D265/32 ,  C07D277/54 ,  C07D291/02 ,  C07D327/06 ,  C07C309/30 ,  C07C327/58 ,  H01L21/027

CPC分类号： C07C327/58 ,  C07C2601/20 ,  C07D209/48 ,  G02B1/14 ,  G02B5/201 ,  G02B5/223 ,  G02F1/133516 ,  G02F1/1339 ,  G02F2001/133519 ,  G03F7/0007 ,  G03F7/031 ,  G03F7/162 ,  G03F7/168 ,  G03F7/2002 ,  G03F7/38 ,  G03F7/40

摘要： Oxime sulfonate compounds of the formula (I), wherein R 1 is O(CO)R 4, COOR 5 or CONR 6R 7; n is 1 or 2; R 2 for example is C 1-C 8alkyl, C 3-C 6cycloalkyl or benzyl; R 3 is for example C 1-C 8alkyl, C 3-C 6cycloalkyl, C 1-C 8haloalkyl, C 2-C 8alkenyl, benzyl, phenyl or naphthyl, which optionally are substituted; R 4 is for example C 1-C 8alkyl, C 3-C 6cycloalkyl, C 1-C 8haloalkyl, C 2-C 8alkenyl, benzyl, phenyl or naphthyl, which optionally are substituted; R 5 is for example C 3-C 20alkyl, C 3-C 14cycloalkyl, C 2-C 8alkenyl, C 1-C 12alkyl which is substituted for example by one or more halogen; or R 5 is phenyl or naphthyl, which are unsubstituted; R 6 and R 7 each independently of one another for example are hydrogen, C 1-C 12alkyl, C 1-C 4haloalkyl, phenyl-C 1-C 4alkyl, C 2-C 8alkenyl or C 3-C 6cycloalkyl, phenyl or naphthyl; or R 6 and R 7, together with the N-atom to which they are attached, form a 5- or 6-membered ring; are suitable as thermal radical initiators.

摘要翻译： 式（I）的肟磺酸酯化合物，其中R 1是O（CO）R 4，COOR 5或CONR 6 R 7; n是1或2; R 2例如为C 1 -C 8烷基，C 3 -C 6环烷基或苄基; R 3例如为任选被取代的C 1 -C 8烷基，C 3 -C 6环烷基，C 1 -C 8卤代烷基，C 2 -C 8链烯基，苄基，苯基或萘基; R 4例如为任选被取代的C 1 -C 8烷基，C 3 -C 6环烷基，C 1 -C 8卤代烷基，C 2 -C 8链烯基，苄基，苯基或萘基; R 5例如为C 3 -C 20烷基，C 3 -C 14环烷基，C 2 -C 8链烯基，例如被一个或多个卤素取代的C 1 -C 12烷基; 或R 5是未取代的苯基或萘基; R 6和R 7各自彼此独立地为例如氢，C 1 -C 12烷基，C 1 -C 4卤代烷基，苯基-C 1 -C 4烷基，C 2 -C 8链烯基或C 3 -C 6环烷基，苯基或萘基 ; 或R 6和R 7与它们所连接的N原子一起形成5-或6-元环; 适合作为热自由基引发剂。

公开(公告)号：EP0510028B1

公开(公告)日：1995-03-15

申请号：EP91901720.2

申请日：1991-01-08

申请人： RHONE-POULENC RORER S.A.

发明人： PALFREYMAN, Malcolm, Norman ,  VICKER, Nigel

IPC分类号： C07D213/59 ,  C07D401/12 ,  C07D409/12 ,  A61K31/44

CPC分类号： C07D213/70 ,  C07C327/46 ,  C07C2601/14 ,  C07C2601/18 ,  C07D213/59 ,  C07D409/12 ,  C07D413/06

摘要： Thioformamide derivatives of formula (I), in which R represents alkyl, Y represents methylene, ethylene or a direct bond, A represents optionally substituted phenyl or heterocyclyl and: R1 represents hydrogen, and R2 represents an N-alkylsulphonyl- or N-phenylsulphonyl-N'-alkylamidino or an aryl- or alkylsulphonyl group; R?1 and R2¿ both independently represents alkyl- or aryl-sulphonyl groups; or R?1 and R2¿ form together with the nitrogen atom a 3,5-dioxomorpholino group or analogue thereof; and salts thereof possess pharmacological activity and are also useful in inhibiting head hair loss.

摘要翻译： 式（I）的硫代甲酰胺衍生物，其中R代表烷基，Y代表亚甲基，亚乙基或直接键，A代表任选取代的苯基或杂环基，和：R 1代表氢，且R 2代表N-烷基磺酰基 - 或N-苯基磺酰基 - N'-烷基脒基或芳基 - 或烷基磺酰基; R 1和R 2都独立地代表烷基或芳基磺酰基; 或R 1和R 2'与氮原子一起形成3,5-二氧代吗啉代基团或其类似物; 及其盐具有药理活性，并且也可用于抑制头部脱发。