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1.发明公开
公开(公告)号：EP0859837A2
公开(公告)日：1998-08-26
申请号：EP96939515.0
申请日：1996-10-25
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要： Nucleic acid molecule which modulates the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor.
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2.发明公开RNA INTERFERENCE MEDIATED INHIBITION OF NF-KAPPA B/REL-A GENE EXPRESSION USING SHORT INTERFEREING NUCLEIC ACID (siNA) 审中-公开RNA干扰介导的表达FOR NF-κB的/ REL-A使用新浪（短干扰核酸）的基因的缓蚀
公开(公告)号：EP1470257A2
公开(公告)日：2004-10-27
申请号：EP03742826.5
申请日：2003-02-20
CPC分类号： C12N15/8218 , A61K38/00 , A61K47/54 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/344 , C12N2310/346 , C12N2310/53 , C12N2320/51 , C12N2330/30 , Y02A50/393 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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3.发明公开METHOD AND REAGENT FOR THE MODULATION AND DIAGNOSIS OF CD20 AND NOGO GENE EXPRESSION 审中-公开方法和试剂调制与表达CD20和NOGO源基因的诊断
公开(公告)号：EP1265995A2
公开(公告)日：2002-12-18
申请号：EP01910515.4
申请日：2001-02-09
IPC分类号： C12N15/11 , C12N9/00 , A61K31/7088 , C12Q1/68 , C07H21/00
CPC分类号： C12N15/1138 , A61K31/7088 , A61K38/00 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/3517 , C12N2310/3521
摘要： The present invention relates to nucleic acid molecules, including antisense and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, and antisense, which modulate the expression of the CD20 and/or NOGO genes. Diagnostic systems and methods for detecting the presence of nucleic acids are further disclosed.
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4.发明公开RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR SUPERFAMILY GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开RNA干扰介导的表达FOR THE TNF和TNF受体超族基因USING siNA的抑制率（短干扰核酸）
公开(公告)号：EP1478730A2
公开(公告)日：2004-11-24
申请号：EP03713502.7
申请日：2003-02-20
IPC分类号： C12N1/00
CPC分类号： C12N15/1138 , C12N15/1136 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/53 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating TNF superfamily and TNF receptor superfamily gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against TNF superfamily and TNF receptor superfamily gene expression and/or activity. The small nucleic acid molecules are useful in the treatment of septic shock, rheumatoid arthritis, HIV and AIDS, psoriasis, inflammatory or autoimmune disorders and any other disease or condition that responds to modulation of TNF and/or TNF receptor expression or activity.
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公开(公告)号：EP0728205A1
公开(公告)日：1996-08-28
申请号：EP95901907.0
申请日：1994-11-10
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/321 , C12Y304/24017 , C12N2310/3521
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an arthritic condition.
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6.发明公开METHOD AND REAGENT FOR INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION 失效方法和试剂的抑制人IMMUNODEFIZIUNG病毒的复制
公开(公告)号：EP0716693A1
公开(公告)日：1996-06-19
申请号：EP94922766.0
申请日：1994-08-04
发明人： DRAPER, Kenneth G. , CHOWRIRA, Bharat , McSWIGGEN, James , STINCHCOMB, Daniel T. , THOMPSON, James D.
摘要： An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
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7.发明公开RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN TYPROSINE PHOSPHATASE-1B (PTP-1B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SiNA) 审中-公开通过RNA干扰介导的使用新浪蛋白酪氨酸磷酸酶-1B（PTP-1B）的基因的表达的抑制（短干扰核酸）
公开(公告)号：EP1476457A2
公开(公告)日：2004-11-17
申请号：EP03742722.6
申请日：2003-02-11
CPC分类号： C12N15/1137 , A61K38/00 , A61K47/54 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/53 , C12Y301/03048 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating PTP-1B gene expression and genes involved in the PTP-1B pathway in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against PTP-1B gene expression. The short interfering nucleic acid molecules are useful in the treatment of cancer, inflammation, obesity and insulin resistance (e.g. Type I and Type II diabetes).
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8.发明公开METHOD AND REAGENT FOR PREVENTION, INHIBITION OF PROGRESSION AND REGRESSION OF VASCULAR DISEASES 失效方法和试剂为防止及显影抑制上升和下降血管疾病
公开(公告)号：EP0800580A1
公开(公告)日：1997-10-15
申请号：EP95943045.0
申请日：1995-12-11
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/321 , C12N2310/322 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535
摘要： A nucleic acid molecule which blocks synthesis and/or expression of mRNAs associated with initial development, progression or regression of vascular disease. In particular are provided ribozyme sequences which cleave human or rabbit cholesterol ester transfer protein (CETP) mRNAs.
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公开(公告)号：EP0728205B1
公开(公告)日：2002-10-16
申请号：EP95901907.6
申请日：1994-11-10
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/321 , C12Y304/24017 , C12N2310/3521
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10.发明公开RIBOZYME TREATMENT OF DISEASES OR CONDITIONS RELATED TO LEVELS OF PLASMA LIPOPROTEIN (a) Lp(a)] BY INHIBITING APOLIPOPROTEIN (a) APO(a)] 失效疾病或结论核酶的治疗，脂蛋白A的等离子体MIRROR（LP（A））的约束，通过抑制阿朴脂蛋白A（APO（A））
公开(公告)号：EP0782622A1
公开(公告)日：1997-07-09
申请号：EP95935028.0
申请日：1995-09-21
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122
摘要： Enzymatic RNA molecules which cleave apo(a) mRNA. Use of these catalytic RNA molecules for the treatment of conditions related to lipoprotein A levels, such as atherosclerosis, myocardial infarction, strokes; testenosis and heart diseases.
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