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13 条记录 (耗时 0.017 秒)

    5-HT4 RECEPTOR AGONIST FOR GASTROPARESIS
    3.
    发明公开
    5-HT4 RECEPTOR AGONIST FOR GASTROPARESIS 审中-公开
    5-HT4-REZEPTORAGONISTFÜRGASTROPARESE

    公开(公告)号：EP3142666A1

    公开(公告)日：2017-03-22

    申请号：EP15793503.2

    申请日：2015-05-18

    申请人： RaQualia Pharma Inc.

    发明人： TAKAHASHI, Nobuyuki ,  YAMAMOTO, Toshinori ,  SHIMADA, Kaoru ,  NOGUCHI, Hirohide

    IPC分类号： A61K31/454 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P17/00 ,  A61P25/00 ,  A61P25/06 ,  A61P25/16 ,  A61P31/12

    摘要： This invention relates to 4-{[4-({([4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]-oxy}methyl)piperidin-1-yl]methyl}tetrahydro-2H-pyran-4-carboxylic acid for use in therapeutic treatment of the human body. In particular, it relates to the compound having selective 5-HT4 receptor agonism, which is useful for treating gastroparesis, or preventing or delaying the onset or the progression of gastroparesis.

    摘要翻译： 本发明涉及4 - {[4 - （{（[4-（2,2,2-三氟乙氧基）-1,2-苯并异恶唑-3-基]氧基}甲基哌啶-1-基]甲基}四氢-2H- - 吡喃-4-羧酸，特别涉及具有选择性5-HT 4受体激动作用的化合物，其可用于治疗胃轻瘫，或预防或延缓发作或进展 胃轻瘫。

    ACID PUMP ANTAGONIST FOR TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL GASTROINTESTINAL MOVEMENT
    5.
    发明公开
    ACID PUMP ANTAGONIST FOR TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL GASTROINTESTINAL MOVEMENT 有权
    ÄANT ANT ON IST EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN

    公开(公告)号：EP2452680A1

    公开(公告)日：2012-05-16

    申请号：EP10797193.9

    申请日：2010-07-09

    申请人： RaQualia Pharma Inc

    发明人： TAKAHASHI, Nobuyuki ,  KOIZUMI, Shinichi

    IPC分类号： A61K31/4188 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506 ,  A61K45/00 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P11/06 ,  A61P31/04 ,  A61P43/00

    摘要： The present invention relates to a use of a compound having an acid pump antagonistic activity, a pharmaceutically acceptable salt thereof or a pharmaceutical composition thereof for the manufacture of a medicament for prevention or treatment of diseases in which abnormal gastrointestinal motility is involved. In addition, the present invention relates to the method of prevention or treatment including administering to a human or animal. The compound, the pharmaceutically acceptable salt thereof, or pharmaceutical compositions containing them, may be used in combination with one or more second active agent. Further, the present invention relates to pharmaceutical compositions and kits comprising a compound having an acid pump antagonistic activity or a pharmaceutically acceptable salt thereof for the prevention or treatment of said diseases.

    摘要翻译： 本发明涉及具有酸泵拮抗活性的化合物，其药学上可接受的盐或其药物组合物在制备用于预防或治疗其中涉及异常胃肠蠕动的疾病的药物中的用途。 此外，本发明涉及预防或治疗方法，包括对人或动物施用。 化合物，其药学上可接受的盐或含有它们的药物组合物可以与一种或多种第二活性剂组合使用。 此外，本发明涉及药物组合物和试剂盒，其包含具有酸泵拮抗活性的化合物或其药学上可接受的盐，用于预防或治疗所述疾病。

    A 5-HT4 RECEPTOR AGONIST AS A PROKINETIC AGENT
    9.
    发明公开
    A 5-HT4 RECEPTOR AGONIST AS A PROKINETIC AGENT 有权
    5-HT 4受体激动剂作为活性促动力

    公开(公告)号：EP2688648A1

    公开(公告)日：2014-01-29

    申请号：EP12761170.5

    申请日：2012-03-23

    申请人： RaQualia Pharma Inc

    发明人： TAKAHASHI, Nobuyuki

    IPC分类号： A61P25/00 ,  A61K31/454 ,  A61P1/00 ,  C07D413/12

    CPC分类号： A61K31/435 ,  A61K31/454 ,  A61K45/06 ,  C07D413/14

    摘要： This invention relates to Compound A or a pharmaceutically acceptable salt thereof with 5-HT4 agonistic activities, which is useful in the treatment of gastrointestinal diseases. This invention also relates to a pharmaceutical composition for the treatment of gastrointestinal diseases which comprises a therapeutically effective amount of Compound A or a pharmaceutically acceptable salt thereof. Further this invention relates to a method for the treatment of gastrointestinal diseases in an animal subject including a mammalian subject, which comprises administering to the animal subject including a mammalian subject Compound A or a pharmaceutically acceptable salt thereof.