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17 条记录 (耗时 0.018 秒)

    MEMORY FIXATION ACCELERATOR
    1.
    发明公开
    MEMORY FIXATION ACCELERATOR 审中-公开
    存储器固定加速器

    公开(公告)号：EP1733722A1

    公开(公告)日：2006-12-20

    申请号：EP05720323.4

    申请日：2005-03-09

    申请人： Research Foundation Itsuu Laboratory ,  R & R Inc.

    发明人： SHUDO, Koichi ,  KAGECHIKA, Hiroyuki

    IPC分类号： A61K31/192 ,  A61K31/695 ,  A61K45/00 ,  A61P25/16 ,  A61P25/28

    CPC分类号： A61K31/192 ,  A61K31/695

    摘要： A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.

    摘要翻译： 一种促进记忆巩固的药物，其包含作为活性成分的非天然类视黄醇，优选具有包含芳香族羧酸或托酚酮与桥连基团结合的芳香环的基本骨架的类维生素A，更优选4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸或4 - [（3,5-双 - 三甲基甲硅烷基苯基） - 氨基甲酰基]苯甲酸。

    SILICON-CONTAINING CARBOXYLIC ACID DERIVATIVE
    3.
    发明公开
    SILICON-CONTAINING CARBOXYLIC ACID DERIVATIVE 审中-公开
    碳化硅碳化硅

    公开(公告)号：EP2700645A1

    公开(公告)日：2014-02-26

    申请号：EP12774607.1

    申请日：2012-04-19

    申请人： Research Foundation Itsuu Laboratory ,  Kemphys Ltd.

    发明人： MURATAKE, Hideaki ,  ITO, Ai ,  SHUDO, Koichi

    IPC分类号： C07F7/10

    CPC分类号： C07F7/0818 ,  C07F7/0816 ,  C07F7/082

    摘要： A compound represented by the formula (I) [R 1 to R 3 represent an alkyl group, an alkenyl group, and the like; n represents 0 or 1; R 4 represents an amino group or - (CX 2 ) m -COOH (m represents 0 to 3, and X represents hydrogen atom); R 5 represents-(CY 2 ) p -COOR 6 (p represents an 0 to 3, Y represents hydrogen atom, and R 6 represents hydrogen atom or an alkyl group)], or a salt thereof.

    摘要翻译： 由式（I）表示的化合物[R 1至R 3表示烷基，烯基等] n表示0或1; R 4表示氨基或 - （CX 2）m -COOH（m表示0〜3，X表示氢原子）。 R 5表示 - （CY 2）p -COOR 6（p表示0〜3，Y表示氢原子，R 6表示氢原子或烷基）]或其盐。

    DRUGS FOR TREATING VASCULAR DISEASES
    4.
    发明公开
    DRUGS FOR TREATING VASCULAR DISEASES 审中-公开
    ARZNEIMITTEL ZUR BEHANDLUNG VONGEFÄSSERKRANKUNGEN

    公开(公告)号：EP1500401A1

    公开(公告)日：2005-01-26

    申请号：EP03717687.2

    申请日：2003-04-22

    申请人： Research Foundation Itsuu Laboratory

    发明人： NAGAI, Ryozo ,  SHINDO, Takayuki ,  MANABE, Ichiro ,  SHUDO, Koichi ,  KAGECHIKA, Hiroyuki

    IPC分类号： A61K45/00 ,  A61K31/27 ,  A61K31/695 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P43/00

    CPC分类号： A61K31/27 ,  A61K31/695 ,  A61L31/16

    摘要： A medicament for prophylactic and/or therapeutic treatment of a vascular disease such as vascular restenosis and/or reocclusion after percutaneous transluminal coronary angioplasty using an intravascular stent, which comprises as an active ingredient a substance selected from the group consisting of retinoids and agents for controlling actions of retinoids such as 4-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or a salt thereof, or 4-[[[3,5-bis-(trimethylsilyl)phenyl]carbonyl]amino]benzoic acid or a salt thereof, wherein said substance has substantially no antiproliferative action on vascular endothelial cells, but substantially has antiproliferative action on vascular smooth muscle cells.

    摘要翻译： 一种用于在使用血管内支架的经皮腔内冠状动脉血管成形术之后进行血管疾病如血管再狭窄和/或再闭塞的预防和/或治疗性治疗药物，其包含选自维甲酸类和控制剂的活性成分 类维生素A 4,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基苯甲酸或其盐或4-哒嗪-3,5-双（三甲基甲硅烷基） 苯基羰基氨基苯甲酸或其盐，其中所述物质对血管内皮细胞基本上没有抗增殖作用，但对血管平滑肌细胞基本具有抗增殖作用。

    SEROTONIN 5-HT3 RECEPTOR AGONIST
    6.
    发明公开
    SEROTONIN 5-HT3 RECEPTOR AGONIST 审中-公开
    AGONIST DES SEROTONIN-5-HT3-REZEPTORS

    公开(公告)号：EP1798227A1

    公开(公告)日：2007-06-20

    申请号：EP05778615.4

    申请日：2005-09-08

    申请人： Research Foundation Itsuu Laboratory

    发明人： JIKYO, Tamaki ,  SHUDO, Koichi

    IPC分类号： C07D295/20 ,  C07D243/08 ,  A61K31/495 ,  A61K31/551 ,  A61K31/395 ,  A61P1/08 ,  A61P1/10 ,  A61P1/12 ,  A61P43/00

    CPC分类号： C07D295/215 ,  A61K31/395 ,  A61K31/495 ,  A61K31/551 ,  C07D243/08

    摘要： A serotonin 5-HT3 receptor agonist containing a compound represented by the general formula (1) [R 1 , R 3 and R 5 represent hydrogen atom, a lower alkyl group, a lower alkenyl group, a halogen atom, hydroxyl group, amino group, a lower alkoxy group, carboxyl group, carbamoyl group, or nitro group, R 2 and R 4 represent a halogen atom, hydroxyl group, or amino group, R 6 represents hydrogen atom, a lower alkyl group, or a lower alkenyl group, R 7 represents hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group, and m and n are integers of 1 to 3] or a physiologically acceptable salt thereof as an active ingredient and having both a serotonin 5-HT3 receptor antagonistic action and a serotonin 5-HT3 receptor activating action.

    摘要翻译： 含有通式（1）表示的化合物的5-羟色胺5-HT 3受体激动剂[R 1，R 3和R 5表示氢原子，低级烷基，低级烯基，卤素原子，羟基，氨基 低级烷氧基，羧基，氨基甲酰基或硝基，R 2和R 4表示卤素原子，羟基或氨基，R 6表示氢原子，低级烷基或低级烯基， R 7表示氢原子，低级烷基，低级烯基或芳烷基，m和n为1〜3的整数]或其生理学上可接受的盐作为活性成分，同时具有5-羟色胺5-HT 3 受体拮抗作用和5-羟色胺5-HT 3受体激活作用。

    DEUTERATED PHENYLPROPIONIC ACID DERIVATIVE
    7.
    发明公开
    DEUTERATED PHENYLPROPIONIC ACID DERIVATIVE 审中-公开
    氘代丙酸衍生物

    公开(公告)号：EP2730559A1

    公开(公告)日：2014-05-14

    申请号：EP12807516.5

    申请日：2012-07-04

    申请人： Research Foundation Itsuu Laboratory

    发明人： MURATAKE, Hideaki ,  SHUDO, Koichi ,  AMANO, Yohei ,  TODA, Takahiro

    IPC分类号： C07C233/65 ,  A61K31/192

    CPC分类号： C07C235/74 ,  C07B59/001 ,  C07C233/65 ,  C07C2602/10

    摘要： A compound corresponding to 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]phenyl]propionic acid in which a part or all of hydrogen atoms in the ethylene group constituting the propionic acid moiety are replaced with deuterium atoms, a salt thereof, or an ester thereof, and a prodrug for releasing Am80 as an active medicament after being absorbed into a living body, which comprises the aforementioned compound, a salt thereof, or an ester thereof as an active ingredient.

    摘要翻译： 对应于3- [4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯基]丙酸的化合物，其中部分或全部氢原子 在构成丙酸部分的亚乙基中被氘原子，其盐或其酯所取代，以及在被生物体吸收后释放作为活性药物的Am80的前药，其包含上述化合物，盐 或其酯作为活性成分。

    RETINOID PRODRUG COMPOUND
    8.
    发明公开
    RETINOID PRODRUG COMPOUND 审中-公开
    类维生素A的前体药物CONNECTION

    公开(公告)号：EP2216322A1

    公开(公告)日：2010-08-11

    申请号：EP07830918.4

    申请日：2007-10-31

    申请人： Research Foundation Itsuu Laboratory

    发明人： MURATAKE, Hideaki ,  SHUDO, Koichi

    IPC分类号： C07C235/84 ,  C07C235/88 ,  C07C237/48 ,  C07C237/52 ,  C07C271/30 ,  C07F7/10

    CPC分类号： C07F7/0818 ,  C07C233/65 ,  C07C235/84 ,  C07C235/88 ,  C07C237/48 ,  C07C237/52 ,  C07C271/30 ,  C07C2602/10

    摘要： A compound represented by the following general formula (I) :

    [R 1 to R 5 represent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents -NH-CO-, -CO-NH-, -N(COR 6 )-CO-, -CO-N(COR 7 )- (R 6 and R 7 represent a lower alkoxy group, or a carboxy-substituted phenyl group) etc.; and Z represents -Y-CH(R 12 )-COOH, -CHO, -CH-CH-COOH, or -COOR 13 (Y represents a single bond, -CH 2 -, -CH(OH)-, -CO-, -CO-NH-, or -CO-NH-CH 2 -CO-NH-, R 12 represents hydrogen atom or a lower alkyl group, and R 13 represents hydrogen atom, -CH(R 14 )-COOH (R 14 represents hydrogen atom, a lower alkyl group, or hydroxy group), -[CH 2 CH 2 -O] n -CH 2 -CH 2 -OH, CH2-O-[CH 2 CH 2 O] m -CH 2 -OH, or -[CH(CH 3 )-CO-O] p -CH(CH 3 )-COOH (m, n and p represent an integer of 1 to 100))], a salt thereof or an ester thereof, which has a property of being converted into a retinoid after absorption in vivo.

    TRICYCLIC AMINE COMPOUND
    10.
    发明公开
    TRICYCLIC AMINE COMPOUND 审中-公开
    三环胺化合物

    公开(公告)号：EP2189440A1

    公开(公告)日：2010-05-26

    申请号：EP08792458.5

    申请日：2008-08-14

    申请人： Research Foundation Itsuu Laboratory

    发明人： AMANO, Yohei ,  NOGUCHI, Masayuki ,  SHUDO, Koichi

    IPC分类号： C07C229/60 ,  A61K31/196 ,  A61K31/505 ,  A61P43/00 ,  C07D239/42

    CPC分类号： C07C229/60 ,  C07C2601/02 ,  C07C2603/28 ,  C07C2603/34 ,  C07D239/42

    摘要： A compound represented by the following general formula (I):

    [wherein R 1 represents hydrogen atom or a C 16 alkyl group, A and B represent -(CH 2 ) 2 -, -(CH 2 ) 3 - or -(CH 2 ) 4 -, X represents -N(R 2 )- (R 2 represents hydrogen atom or a C 1-6 alkyl group), -CO-, -C(=N-R 3 )- (R 3 represents hydrogen atom or a C 1-6 alkyl group), or - C(=C(R 4 )(R 5 ))- (R 4 and R 5 independently represent hydrogen atom or a C 1-6 alkyl group), and Ar represents an aryldiyl group or a heteroaryldiyl group], which has an action of controlling physiological activities of retinoids and useful as an active ingredient of a medicament.

    摘要翻译： 由下述通式（I）表示的化合物：[其中R 1表示氢原子或C 16烷基，A和B表示 - （CH 2）2 - ， - （CH 2）3 - 或 - （CH 2）4 - ，X 表示-N（R 2） - （R 2表示氢原子或C 1-6烷基），-CO - ， - C（= N-R 3） - （R 3表示氢原子或C 1-6烷基） C（= C（R 4）（R 5）） - （R 4和R 5分别独立地表示氢原子或C 1-6烷基），Ar表示芳基二基或杂芳基二基]，其具有控制 类视黄醇并且可用作药物的活性成分。