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公开(公告)号：EP1853573A1
公开(公告)日：2007-11-14
申请号：EP06736085.9
申请日：2006-02-24
发明人： HONG, Hui , GOLDSTEIN, Eileen , STAUFFER, Emily , GOFF, Dane , KOLLURI, Rao , DARWISH, Ihab , SINGH, Rajinder , LU, Henry
IPC分类号： C07D275/04 , C07D513/04 , A61K31/425 , A61P31/12
CPC分类号： C07D275/04 , C07D417/12 , C07D513/04
摘要： The present invention relates to benzisothiazoles and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the benzisothiazoles and pharmaceutical compositions comprising the compounds to treat or prevent HCV infections.
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2.发明公开DERIVATIVES OF N2-(3-PYRIDIL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES 有权用于治疗炎性，自身免疫疾病或增殖性病症Ñ2-（3-吡啶基或苯基）-N4-（哌啶-4-基）-2,4- PYRIMIDINEDIAMIN的合适的衍生物的治疗
公开(公告)号：EP2389373A1
公开(公告)日：2011-11-30
申请号：EP10701773.3
申请日：2010-01-21
发明人： SINGH, Rajinder , LI, Hui , ZHAO, Haoran , KOLLURI, Rao , TSO, Kin , RAMPHAL, John , GU, Shihai , VALDEZ, Carlos , ZHANG, Jing , STAUFFER, Emily , DUNCTON, Matthew , ALVAREZ, Salvador
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , A61K31/506 , A61P37/00
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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3.发明授权DERIVATIVES OF N2-(3-PYRIDYL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES 有权用于治疗炎性，自身免疫疾病或增殖性病症Ñ2-（3-吡啶基或苯基）-N4-（哌啶-4-基）-2,4- PYRIMIDINEDIAMIN的合适的衍生物的治疗
公开(公告)号：EP2389373B1
公开(公告)日：2017-05-17
申请号：EP10701773.3
申请日：2010-01-21
发明人： SINGH, Rajinder , LI, Hui , ZHAO, Haoran , KOLLURI, Rao , TSO, Kin , RAMPHAL, John , GU, Shihai , VALDEZ, Carlos , ZHANG, Jing , STAUFFER, Emily , DUNCTON, Matthew , ALVAREZ, Salvador
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , A61K31/506 , A61P37/00
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
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