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1.发明公开ISOTOPE LABELED 2-ARYLPROPIONIC ACID COMPOUNDS AND PROCESS FOR PRODUCTION OF SAME, AND MOLECULAR PROBE FOR POSITRON EMISSION TOMOGRAPHY AND METHOD FOR IMAGING OF CYCLOOXYGENASE AND THE LIKE USING SAME 有权具有显着的同位素2ARYLPROPIONSÄUREVERBINDUNGEN和生产性分子探针用于成像过程中发射正电子的方法和环氧合酶和类似设备的图片，以便
公开(公告)号：EP2463263A1
公开(公告)日：2012-06-13
申请号：EP10806375.1
申请日：2010-07-29
申请人： Riken
发明人： TAKASHIMA, Misato , SHUKURI, Miho , GOTO, Miki , DOI, Hisashi , ONOE, Hirotaka , SUZUKI, Masaaki , WATANABE, Yasuyoshi
IPC分类号： C07C57/30 , A61K51/00 , C07C51/353 , C07C57/58 , C07C59/64 , C07C59/68 , C07C59/84 , C07C59/86 , C07C67/333 , C07C69/612 , C07C69/65 , C07C69/734 , C07C69/736 , C07C69/738 , G01T1/161
CPC分类号： A61K31/192 , A61K49/0433 , A61K51/04 , A61K51/0402 , C07B59/001 , C07B2200/05 , C07B2200/07 , C07C57/30 , C07C57/58 , C07C59/64 , C07C59/68 , C07C59/84 , C07C59/86 , C07C69/612 , C07C69/65 , C07C69/734 , C07C69/736 , C07C69/738 , C07C2601/08
摘要： Disclosed are: labeled NSAIDs compounds which can be produced within a short time, can be used suitably for a PET method, and enable the imaging of cyclooxygenase-2; and a process for producing the labeled NSAIDs compounds. Specifically disclosed are isotope-labeled 2-arylpropionic acid compounds, each of which is a compound represented by general formula (1) (wherein Ar represents an aryl group which may have a substituent; R1 represents any one selected from 11CH3, CH2 18F and CF2 18F; and R2 represents a hydrogen atom, or an alkyl group which may have a branch, wherein a compound wherein Ar is a benzene ring, R1 is 11CH3, and R2 is a hydrogen atom is excluded), or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof.
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2.发明授权ISOTOPE LABELED 2-ARYLPROPIONIC ACID COMPOUNDS AND PROCESS FOR PRODUCTION OF SAME, AND MOLECULAR PROBE FOR POSITRON EMISSION TOMOGRAPHY AND METHOD FOR IMAGING OF CYCLOOXYGENASE AND THE LIKE USING SAME 有权具有显着的同位素2ARYLPROPIONSÄUREVERBINDUNGEN和生产性分子探针用于成像过程中发射正电子的方法和环氧合酶和类似设备的图片，以便
公开(公告)号：EP2463263B1
公开(公告)日：2014-04-23
申请号：EP10806375.1
申请日：2010-07-29
申请人： Riken
发明人： TAKASHIMA, Misato , SHUKURI, Miho , GOTO, Miki , DOI, Hisashi , ONOE, Hirotaka , SUZUKI, Masaaki , WATANABE, Yasuyoshi
IPC分类号： C07C57/30 , A61K51/00 , C07C51/353 , C07C57/58 , C07C59/64 , C07C59/68 , C07C59/84 , C07C59/86 , C07C67/333 , C07C69/612 , C07C69/65 , C07C69/734 , C07C69/736 , C07C69/738 , G01T1/161
CPC分类号： A61K31/192 , A61K49/0433 , A61K51/04 , A61K51/0402 , C07B59/001 , C07B2200/05 , C07B2200/07 , C07C57/30 , C07C57/58 , C07C59/64 , C07C59/68 , C07C59/84 , C07C59/86 , C07C69/612 , C07C69/65 , C07C69/734 , C07C69/736 , C07C69/738 , C07C2601/08
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