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公开(公告)号：EP3293508B1
公开(公告)日：2020-03-11
申请号：EP17187263.3
申请日：2017-08-22
申请人： Rion Co., Ltd.
发明人： SEKIMOTO, Kazuma
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公开(公告)号：EP3786615A1
公开(公告)日：2021-03-03
申请号：EP20193327.2
申请日：2020-08-28
申请人： Rion Co., Ltd.
发明人： SEKIMOTO, Kazuma
摘要： A microbial particle measuring apparatus includes: a light emitter configured to irradiate a fluid with light of a predetermined wavelength over a predetermined measurement time; a fluorescence receiver configured to selectively receive fluorescence emitted from particles contained in the fluid and output a signal having a magnitude corresponding to intensity of the fluorescence; a signal acquisition unit configured to obtain the signal output from the fluorescence receiver at regular intervals over the measurement time; and a determiner configured to calculate a slope of waveform of the signal obtained by the signal acquisition unit, and determine a concentration of microbial particles contained in the fluid using an attenuation amount of fluorescence intensity generated in a time period in which the slope in the measurement time is smaller than a predetermined value as an amount of attenuation derived from the microbial particles.
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公开(公告)号：EP3211402A1
公开(公告)日：2017-08-30
申请号：EP17165496.5
申请日：2012-11-28
申请人： Rion Co., Ltd.
CPC分类号： G01J3/4406 , A61M1/16 , A61M1/1605 , A61M1/168 , A61M2205/3306 , A61M2205/52 , C02F1/008 , C02F1/44 , C02F2209/003 , C02F2209/005 , C02F2209/105 , G01N15/1459 , G01N21/6428 , G01N21/645 , G01N2015/1486
摘要： There is provided an art capable of detecting viable particles in a liquid and counting the number of the viable particles even if there is an influence of a Raman-scattered light by water.
There are provided: a light emitting means (10) which radiates a light with a predetermined wavelength toward a liquid containing a detection target; an autofluorescence selecting optical means (70) which reduces transmission of a Raman-scattered light emitted from the liquid out of lights emitted due to an interaction of the target or the liquid with the light radiated from the light emitting means (10) and transmits an autofluorescence emitted from the target; and a viable particle determining means (2) which determines whether or not the target contained in the liquid is a viable particle, based on a light obtained after the Raman-scattered light is reduced by the autofluorescence selecting optical means (70), and the light emitting means (10) radiates the light with the predetermined wavelength that causes the autofluorescence and the Raman-scattered light to be different in peak wavelength.摘要翻译： 提供了一种技术，该技术能够检测液体中的活颗粒并且即使存在由水引起的拉曼散射光的影响也能计数活颗粒的数量。 提供：发光装置（10），其朝着包含检测目标的液体发射具有预定波长的光; 自发光选择光学装置（70），其减少由于目标或液体与从光发射装置（10）辐射的光的相互作用而发射的光中从液体发射的拉曼散射光的透射，并且透射 从目标发射的自发荧光; 以及基于由自发光选择光学装置（70）降低拉曼散射光后获得的光来确定包含在液体中的靶是否为活颗粒的可行颗粒确定装置（2），以及 发光装置（10）发射具有使自发荧光和拉曼散射光的峰值波长不同的预定波长的光。
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4.发明公开
公开(公告)号：EP3395938A1
公开(公告)日：2018-10-31
申请号：EP16878328.0
申请日：2016-12-05
申请人： Rion Co., Ltd.
发明人： SEKIMOTO, Kazuma , OOHASHI, Yuki , SANNOMIYA, Takashi , NAKAJIMA, Tsutomu , FUKUDA, Miyuki , UENO, Masaru , UEYA, Yuuichi
摘要： The biological particle counter has a first circuit configured to generate a first signal corresponding to fluorescence from the biological particle in response to irradiated light. A measurement value obtainer is configured to obtain, from the biological particle counter, a voltage value of the first signal for a calibration particle obtained in such a manner that a fluorescence agent infiltrates into a surface of a polystyrene particle. A circuit adjuster is configured to use reference data indicating a correspondence relation between a fluorescence agent parameter value correlated to the content of the fluorescence agent and a reference voltage value of the first signal corresponding to the fluorescence agent parameter value, thereby specifying the reference voltage value of the first signal corresponding to the fluorescence agent parameter value for the calibration particle. The first circuit is adjusted such that the voltage value of the first signal for the calibration particle reaches the reference voltage value.
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5.发明公开
公开(公告)号：EP3293508A1
公开(公告)日：2018-03-14
申请号：EP17187263.3
申请日：2017-08-22
申请人： Rion Co., Ltd.
发明人： SEKIMOTO, Kazuma
摘要： A microviable particle counting system includes: a microviable particle counting instrument configured to detect autofluorescence of a microviable particle in a sample as fluid, thereby counting the microviable particle in the sample; and a former-stage irradiator provided at a former stage of the microviable particle counting instrument to irradiate the sample with ultraviolet light. The ultraviolet light contains first ultraviolet light having such a wavelength that a carbon-carbon covalent bond is disconnected, and the first ultraviolet light has a wavelength shorter than 200 nm.
摘要翻译： 一种微粒子粒子计数系统，包括：微粒子粒子计数装置，用于检测样本中微粒子作为流体的自发荧光，从而对样本中的微粒子进行计数; 以及前级照射器，设置在微型粒子计数仪的前级，用紫外线照射样品。 紫外线包含具有碳 - 碳共价键断开的波长的第一紫外光，并且第一紫外光具有短于200nm的波长。
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公开(公告)号：EP3546924A1
公开(公告)日：2019-10-02
申请号：EP17874689.7
申请日：2017-11-07
申请人： Rion Co., Ltd.
发明人： SEKIMOTO, Kazuma
摘要： A microbial particle is accurately counted in distinction from a non-microbial particle. A preceding-stage irradiation section 2 irradiates a sample as fluid with ultraviolet light at a preceding stage of a microbial particle counter 1. The ultraviolet light is ultraviolet light having a deep ultraviolet region, the ultraviolet light increasing the fluorescence intensity of a first autofluorescence substance in the microbial particle. The microbial particle counter 1 measures light intensity in a first wavelength range including the fluorescence wavelength of the first autofluorescence substance. In addition, the microbial particle counter 1 measures light intensity in a specific second wavelength range. Further, the microbial particle counter 1 counts the microbial particle in distinction from a non-microbial particle in the fluid based on the measured light intensity in the first wavelength range and the measured light intensity in the specific second wavelength range.
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公开(公告)号：EP3211402B1
公开(公告)日：2018-07-11
申请号：EP17165496.5
申请日：2012-11-28
申请人： Rion Co., Ltd.
CPC分类号： G01J3/4406 , A61M1/16 , A61M1/1605 , A61M1/168 , A61M2205/3306 , A61M2205/52 , C02F1/008 , C02F1/44 , C02F2209/003 , C02F2209/005 , C02F2209/105 , G01N15/1459 , G01N21/6428 , G01N21/645 , G01N2015/1486
摘要： There is provided an art capable of detecting viable particles in a liquid and counting the number of the viable particles even if there is an influence of a Raman-scattered light by water. There are provided: a light emitting means (10) which radiates a light with a predetermined wavelength toward a liquid containing a detection target; an autofluorescence selecting optical means (70) which reduces transmission of a Raman-scattered light emitted from the liquid out of lights emitted due to an interaction of the target or the liquid with the light radiated from the light emitting means (10) and transmits an autofluorescence emitted from the target; and a viable particle determining means (2) which determines whether or not the target contained in the liquid is a viable particle, based on a light obtained after the Raman-scattered light is reduced by the autofluorescence selecting optical means (70), and the light emitting means (10) radiates the light with the predetermined wavelength that causes the autofluorescence and the Raman-scattered light to be different in peak wavelength.
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8.发明授权BIOLOGICAL PARTICLE COUNTER, BIOLOGICAL PARTICLE COUNTING METHOD, DIALYSATE MONITORING SYSTEM, AND WATER PURIFICATION MONITORING SYSTEM 有权生物颗粒计数器，生物颗粒计数方法，DIALYSATE监测系统和水质净化监测系统
公开(公告)号：EP2790008B1
公开(公告)日：2017-11-15
申请号：EP12855154.6
申请日：2012-11-28
申请人： Rion Co., Ltd.
CPC分类号： G01J3/4406 , A61M1/16 , A61M1/1605 , A61M1/168 , A61M2205/3306 , A61M2205/52 , C02F1/008 , C02F1/44 , C02F2209/003 , C02F2209/005 , C02F2209/105 , G01N15/1459 , G01N21/6428 , G01N21/645 , G01N2015/1486
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9.发明公开BIOLOGICAL PARTICLE COUNTER, BIOLOGICAL PARTICLE COUNTING METHOD, DIALYSATE MONITORING SYSTEM, AND WATER PURIFICATION MONITORING SYSTEM 有权生物颗粒计数器，生物颗粒计数方法，DIALYSATE监测系统和水质净化监测系统
公开(公告)号：EP2790008A1
公开(公告)日：2014-10-15
申请号：EP12855154.6
申请日：2012-11-28
申请人： Rion Co., Ltd.
CPC分类号： G01J3/4406 , A61M1/16 , A61M1/1605 , A61M1/168 , A61M2205/3306 , A61M2205/52 , C02F1/008 , C02F1/44 , C02F2209/003 , C02F2209/005 , C02F2209/105 , G01N15/1459 , G01N21/6428 , G01N21/645 , G01N2015/1486
摘要： There is provided an art capable of detecting viable particles in a liquid and counting the number of the viable particles even if there is an influence of a Raman-scattered light by water.
There are provided: a light emitting means (10) which radiates a light with a predetermined wavelength toward a liquid containing a detection target; an autofluorescence selecting optical means (70) which reduces transmission of a Raman-scattered light emitted from the liquid out of lights emitted due to an interaction of the target or the liquid with the light radiated from the light emitting means (10) and transmits an autofluorescence emitted from the target; and a viable particle determining means (2) which determines whether or not the target contained in the liquid is a viable particle, based on a light obtained after the Raman-scattered light is reduced by the autofluorescence selecting optical means (70), and the light emitting means (10) radiates the light with the predetermined wavelength that causes the autofluorescence and the Raman-scattered light to be different in peak wavelength.摘要翻译： 提供了一种技术，该技术能够检测液体中的活颗粒并且即使存在由水引起的拉曼散射光的影响也能计数活颗粒的数量。 提供：发光装置（10），其朝着包含检测目标的液体发射具有预定波长的光; 自发光选择光学装置（70），其减少由于目标或液体与从光发射装置（10）辐射的光的相互作用而发射的光中从液体发射的拉曼散射光的透射，并且透射 从目标发射的自发荧光; 以及基于由自发光选择光学装置（70）降低拉曼散射光后获得的光来确定包含在液体中的靶是否为活颗粒的可行颗粒确定装置（2），以及 发光装置（10）发射具有使自发荧光和拉曼散射光的峰值波长不同的预定波长的光。
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