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1.发明公开VERFAHREN UND VORRICHTUNG ZUR BESTIMMUNG EINES LICHTTRANSPORTPARAMETERS UND EINES ANALYTEN IN EINER BIOLOGISCHEN MATRIX 有权方法和一种用于确定光传输和参数分析物在生物MATRIX
公开(公告)号：EP1463443A2
公开(公告)日：2004-10-06
申请号：EP02795119.3
申请日：2002-12-07
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/49
摘要： The invention relates to a method for selectively determining the index of dispersion µs in a biological dispersion matrix, especially for the non-invasive determination of the concentration of glucose in the skin, with the aid of detection measuring, whereby respective light is radiated as a primary light (9) in the biological matrix (5) and measurement occurs for an intensity measuring value of exposed secondary light (12) exiting from a detection point (33-40), which is disposed at various measuring distances (ρ) from the respective point of radiation (10) during said detection measurements. In order to improve the quality and selectivity of the determination of µs, the primary light is radiated by means of a contacting light guiding element at an oblique angle of between 5° and 85°. At least two detection measurements of the measuring interval (ρ) between the respective radiation point (10) and the respective detection point (33-40) corresponds to a maximum five fold value of the average path length of the propagating light in the biological matrix.
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2.发明授权VERFAHREN UND VORRICHTUNG ZUR BESTIMMUNG EINES LICHTTRANSPORTPARAMETERS UND EINES ANALYTEN IN EINER BIOLOGISCHEN MATRIX 有权方法和一种用于确定光传输和参数分析物在生物MATRIX
公开(公告)号：EP1463443B1
公开(公告)日：2008-07-23
申请号：EP02795119.3
申请日：2002-12-07
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/49
摘要： The invention relates to a method for selectively determining the index of dispersion µs in a biological dispersion matrix, especially for the non-invasive determination of the concentration of glucose in the skin, with the aid of detection measuring, whereby respective light is radiated as a primary light (9) in the biological matrix (5) and measurement occurs for an intensity measuring value of exposed secondary light (12) exiting from a detection point (33-40), which is disposed at various measuring distances (ρ) from the respective point of radiation (10) during said detection measurements. In order to improve the quality and selectivity of the determination of µs, the primary light is radiated by means of a contacting light guiding element at an oblique angle of between 5° and 85°. At least two detection measurements of the measuring interval (ρ) between the respective radiation point (10) and the respective detection point (33-40) corresponds to a maximum five fold value of the average path length of the propagating light in the biological matrix.
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公开(公告)号：EP1420694A1
公开(公告)日：2004-05-26
申请号：EP02790166.9
申请日：2002-07-17
CPC分类号： A61B5/150419 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/15045 , A61B5/150503 , A61B5/15113 , A61B5/15115 , A61B5/15186 , A61B5/157 , Y10T29/49826
摘要： A system for collecting small amounts of body fluids, comprising a drive unit with a holder which moves from a first position to a second position when the drive unit is activated, and a disposable piercing unit with a retaining zone which is removably disposed in the holder, enabling the proximal end of a longitudinal capillary structure to be connected to at least one capillary channel for conveying body fluid and the distal end of the capillary structure is suitable for piercing skin. When the holder is arranged in the first position, the distal end of the capillary structure is located outside the skin. In the second position, said end penetrates the skin to a specific depth which is the depth of penetration. The invention is characterized in that the at least one capillary channel is outwardly open, at least in one region encompassing at least one part of the longitudinal extension of the capillary structure.
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公开(公告)号：EP1868500A1
公开(公告)日：2007-12-26
申请号：EP06724086.1
申请日：2006-04-06
发明人： SAROFIM, Emad , CALASSO, Irio, Giuseppe , KORNER, Stephan , ABT, Reto , HEIN, Heinz-Michael , JAEGGI, Rainer , GRISS, Patrick
IPC分类号： A61B5/151
CPC分类号： A61B5/150503 , A61B5/0531 , A61B5/150022 , A61B5/150068 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/15107 , A61B5/15117 , A61B5/15123 , A61B5/15186
摘要： The invention relates to a method and a device for the extraction of a body fluid, whereby a piercing element (10) is inserted, by way of an advance movement (54), through the skin into a body part (14) and the body fluid is received via a capillary structure (18) of the piercing element (10). The invention is characterized by detecting any contact of the piercing element (10) with body fluid after the advance movement (54) and during a collection phase (62) inside the body part (14).
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5.发明授权FLUORESCEINISOTHIOCYANAT-(FITC)-SINISTRIN, SEINE HERSTELLUNG UND VERWENDUNG 有权异硫氰酸荧光素（FITC）-SINISTRIN，其生产和使用
公开(公告)号：EP1290035B1
公开(公告)日：2004-02-11
申请号：EP01940413.6
申请日：2001-05-08
CPC分类号： A61K49/0054 , A61K49/0043 , C08B37/0051 , Y10T436/143333
摘要： The invention relates to fluorescein isothiocyanate sinistrin (FITC sinistrin), to a method for the production thereof, to its use as a marker substance in a diagnostic agent and to a corresponding diagnostic agent.
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6.发明授权
公开(公告)号：EP0760091B1
公开(公告)日：1999-11-03
申请号：EP95917276.8
申请日：1995-05-03
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/49
摘要： A process for determining the concentration of an analyte in a biological sample in which light is irradiated in a detection step into the sample by means of radiation devices through a surface bounding the biological sample as primary light and light emitted from the biological sample by a surface bounding it is detected at a predetermined measuring distance as secondary light in order to determine a variable physical property of the light owing to the interaction with the biological sample which is measurable as a measurement which is correlated with the concentration of the component in the biological sample, and the concentration of the component is found in an evaluation step on the basis of the measurement made in the detection step. In order to obtain good accuracy of measurement without a reagent and non-invasively, it is proposed that, in the detection step: (a) frequency domain spectroscopic measurements be made with at least two different measurement light paths between the irradiation and measurement points without moving the light irradiation device; (b) each of the frequency domain spectroscopic measurements be made at at least two different light wavelengths; and (c) the phase shift in the secondary light in relation to the primary light and an intensity value be determined in the frequency domain spectroscopic measurements.
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公开(公告)号：EP1921992A1
公开(公告)日：2008-05-21
申请号：EP06776642.8
申请日：2006-08-05
发明人： HEIN, Heinz-Michael , CALASSO, Irio , LIST, Hans
IPC分类号： A61B5/15
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150068 , A61B5/150152 , A61B5/150175 , A61B5/150419 , A61B5/150427 , A61B5/150511 , A61B5/15123 , A61B5/1519 , A61B5/15194 , Y10T83/0481
摘要： The invention relates to a method for producing a hole in the skin in order to remove a body fluid sample from the body part, wherein an opening (21) is produced on the skin on the point of the hole in the epidermis (20) in the skin-opening step. Then, a sample removing hole is created by means of a pricking element (11) in the sample removing step, wherein the skin opening (21) is deepened by means of the pricking element (11) and then a hole, which is used to remove the sample, is produced. The invention also relates to a hand-held device for carrying out said method.
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公开(公告)号：EP1611537A2
公开(公告)日：2006-01-04
申请号：EP04725920.5
申请日：2004-04-06
IPC分类号： G06F19/00
摘要： The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.
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9.发明公开FLUORESCEINISOTHIOCYANAT-(FITC)-SINISTRIN, SEINE HERSTELLUNG UND VERWENDUNG 有权异硫氰酸荧光素（FITC）-SINISTRIN，其生产和使用
公开(公告)号：EP1290035A1
公开(公告)日：2003-03-12
申请号：EP01940413.6
申请日：2001-05-08
CPC分类号： A61K49/0054 , A61K49/0043 , C08B37/0051 , Y10T436/143333
摘要： The invention relates to fluorescein isothiocyanate sinistrin (FITC sinistrin), to a method for the production thereof, to its use as a marker substance in a diagnostic agent and to a corresponding diagnostic agent.
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公开(公告)号：EP1420694B1
公开(公告)日：2011-08-24
申请号：EP02790166.9
申请日：2002-07-17
CPC分类号： A61B5/150419 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/15045 , A61B5/150503 , A61B5/15113 , A61B5/15115 , A61B5/15186 , A61B5/157 , Y10T29/49826
摘要： A system for collecting small amounts of body fluids, comprising a drive unit with a holder which moves from a first position to a second position when the drive unit is activated, and a disposable piercing unit with a retaining zone which is removably disposed in the holder, enabling the proximal end of a longitudinal capillary structure to be connected to at least one capillary channel for conveying body fluid and the distal end of the capillary structure is suitable for piercing skin. When the holder is arranged in the first position, the distal end of the capillary structure is located outside the skin. In the second position, said end penetrates the skin to a specific depth which is the depth of penetration. The invention is characterized in that the at least one capillary channel is outwardly open, at least in one region encompassing at least one part of the longitudinal extension of the capillary structure.
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