专利检索 ap:("Rutgers, The State University of New Jersey") AND inv:"GAFFNEY, Barbara L." 第 1 页

1.

发明公开
COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING 审中-公开
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERNDNDUNG DER SIGNALISIERUNGSEKUNDÄRERBOTENSTOFFE

公开(公告)号：EP2991655A1

公开(公告)日：2016-03-09

申请号：EP14791101.0

申请日：2014-04-29

申请人： Memorial Sloan Kettering Cancer Center , The Rockefeller University , Rutgers, the State University of New Jersey , University of Bonn

发明人： PATEL, Dinshaw J. , TUSCHL, Thomas , ASCANO, Manuel , WU, Yang , LIU, Yizhou , BARCHET, Winfried , HARTMANN, Gunther , ZILLINGER, Thomas , JONES, Roger , GAFFNEY, Barbara L. , GAO, Pu

IPC分类号： A61K31/708 , A61K31/7076 , A61K31/7084

CPC分类号： C07H21/00 , A61K31/522 , A61K47/55 , C07F9/65746 , C12Q1/485 , C12Y207/07 , G01N2500/04 , G01N2500/10 , G06F19/16 , G06F19/18 , G06K9/00147 , G06K9/46

摘要： The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.

摘要翻译： 本发明涉及与cGAMP的异构体的使用和/或开发相关的组合物，方法，试剂盒和测定以及酶cGAS的结构。

2.

发明公开
COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING 审中-公开

公开(公告)号：EP4398254A3

公开(公告)日：2024-10-23

申请号：EP24167296.3

申请日：2014-04-29

申请人： Memorial Sloan Kettering Cancer Center , The Rockefeller University , Rutgers, The State University of New Jersey , University of Bonn

发明人： PATEL, Dinshaw J. , TUSCHL, Thomas , ASCANO, Manuel , WU, Yang , LIU, Yizhou , BARCHET, Winfried , HARTMANN, Gunther , ZILLINGER, Thomas , JONES, Roger , GAFFNEY, Barbara L. , GAO, Pu

IPC分类号： C07F9/6564 , A61K31/708 , A61K31/7076 , A61K31/7084 , C07F9/6574 , C07H21/00 , C12Q1/48 , A61K31/522 , A61K47/55 , A61P1/00 , A61P1/16 , A61P3/00 , A61P3/02 , A61P3/06 , G16B15/00 , G16B20/00 , G16B20/50

摘要： The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.

3.

发明公开
COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING 审中-实审

公开(公告)号：EP4398254A2

公开(公告)日：2024-07-10

申请号：EP24167296.3

申请日：2014-04-29

申请人： Memorial Sloan Kettering Cancer Center , The Rockefeller University , Rutgers, The State University of New Jersey , University of Bonn

发明人： PATEL, Dinshaw J. , TUSCHL, Thomas , ASCANO, Manuel , WU, Yang , LIU, Yizhou , BARCHET, Winfried , HARTMANN, Gunther , ZILLINGER, Thomas , JONES, Roger , GAFFNEY, Barbara L. , GAO, Pu

IPC分类号： G16B20/00

CPC分类号： C07F9/65746 , A61K47/55 , A61K31/522 , G16B15/00 , G16B20/00 , C07H21/00 , C12Y207/07 , A61P1/00 , A61P1/04 , A61P1/16 , A61P11/00 , A61P13/00 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/02 , A61P29/00 , A61P3/00 , A61P3/02 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P3/06 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , A61P5/14 , A61P7/00 , A61P7/02 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/10 , A61P3/10 , G16B20/30 , G16B20/50

摘要： The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.

4.

发明公开
SYNTHESIS OF CYCLIC DIGUANOSINE MONOPHOSPHATE AND THIOPHOSPHATE ANALOGS THEREOF 审中-公开
标题翻译：循环DIGUANOSINMONOPHOSPHAT和硫代磷酸类似物的合成方法

公开(公告)号：EP2448954A1

公开(公告)日：2012-05-09

申请号：EP10733077.1

申请日：2010-07-01

申请人： Rutgers, The State University of New Jersey

发明人： JONES, Roger A. , GAFFNEY, Barbara L.

IPC分类号： C07H21/02 , C07H19/20 , A61K31/7084

CPC分类号： C07H19/213 , C07H23/00

摘要： The invention provides methods for the synthesis of cyclic dinucleotides and thiophosphate analogs thereof as well as a new family of analogs of cyclic diguanosine monophosphate that includes a series of seven phosphorothioate derivatives that includes diastereomers of mono-, di-, and trithiophosphates.