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公开(公告)号：EP1167357A4
公开(公告)日：2002-06-05
申请号：EP00915361
申请日：2000-04-06
申请人： SANKYO CO
发明人： FUJITA TAKASHI , WADA KUNIO , OGUCHI MINORU , HONMA HIDEHITO , FUJIWARA TOSHIHIKO , IWABUCHI HARUO
IPC分类号： A61K31/4184 , A61K31/7056 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/12 , A61P11/06 , A61P25/00 , A61P27/12 , A61P29/00 , A61P35/00 , A61P43/00 , C07D235/06 , C07D235/12 , C07D471/04 , C07H17/02 , C07D235/16 , A61K31/437 , A61K31/4439 , C07D401/12
CPC分类号： C07D471/04 , C07D235/06 , C07D235/12 , C07H17/02
摘要： α-Substituted carboxylic acid derivatives represented by general formula (I), pharmacologically acceptable salts of the same, or pharmacologically acceptable esters or amides thereof, which are useful as therapeutic and/or preventive agents for diabetes, impaired glucose tolerance, diabetes in pregnancy, and so on; wherein R1 is alkyl or the like; R2 is hydrogen or the like; R3 is hydrogen or the like; A is =CH- or the like; B is oxygen or the like; W1 is C1-C8 alkylene; W2 is a single bond or C1-C8 alkylene; X is hydrogen or the like; Y is oxygen or the like; and Z1 is alkoxy or the like.
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公开(公告)号：EP1167366A4
公开(公告)日：2003-05-28
申请号：EP00915362
申请日：2000-04-06
申请人： SANKYO CO
IPC分类号： A61K31/427 , A61P3/10 , A61P19/10 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/422 , A61K31/437
CPC分类号： C07D413/12 , A61K31/427 , C07D417/12 , C07D471/04
摘要： Amine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, which are useful as therapeutic and/or preventive agents for diabetes, hyperlipemia, arteriosclerosis, cancers, and so on: wherein R1 is optionally substituted carbamoyl or the like; R2 is hydrogen or the like; R3 is C1-C10 alkyl or the like; W1, W2 and W3 are each independently a single bond or C1-C8 alkylene; X, Y and Q are each sulfur or the like; Z is =CH- or the like; Ar is a benzene ring or the like; and L is hydrogen or the like.
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