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1.发明授权POLYSACCHARIDES DE SYNTHESE, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LE CONTENANT 有权合成多糖，PROCESS FOR THEIR和含有药物组合物
公开(公告)号：EP1049721B1
公开(公告)日：2001-11-21
申请号：EP99900524.2
申请日：1999-01-13
申请人： SANOFI-SYNTHELABO , Akzo Nobel N.V.
发明人： BASTEN, Johannes , DREEF-TROMP, Cornelia , DRIGUEZ, Pierre-Alexandre , DUCHAUSSOY, Philippe , HERBERT, Jean-Marc , PETITOU, Maurice , VAN BOECKEL, Constant
IPC分类号： C08B37/00 , A61K31/715
CPC分类号： C08B37/0063
摘要： The invention relates to synthetic polysaccharides in an acid form and their pharmaceutically acceptable salts, the anionic form of which complies with one of the formulas (I) to (V) described in claim 1. Said polysaccharides can be used in the treatment of diseases linked to coagulation disorders.
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2.发明授权NOUVEAUX PENTASACCHARIDES, PROCEDES POUR LEURS PREPARATIONS ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT 有权五糖，PROCESS FOR THEIR和药物制剂包含您
公开(公告)号：EP1049706B1
公开(公告)日：2003-05-28
申请号：EP99900525.9
申请日：1999-01-13
申请人： SANOFI-SYNTHELABO , Akzo Nobel N.V.
发明人： PETITOU, Maurice
CPC分类号： C07H15/04 , C08B37/0078
摘要： The invention relates to a pentasaccharide in an acid form and its pharmaceutically acceptable salts, the anionic form of which is described by formula (I), in which R1 is (C1-C3) alkyl; R is hydrogen, an -SO3- group, (C¿1?-C3) alkyl or (C2-C3) acyl; T is hydrogen or an ethyl group; and n is 1 or 2.
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3.发明公开POLYSACCHARIDES A ACTIVITE ANTITHROMBOTIQUE COMPRENANT AU MOINS UNE LIAISON COVALENTE AVEC LA BIOTINE OU UN DERIVE DE LA BIOTINE 有权具有抗血栓作用的多糖，用生物素或BIOTENDERIVAT共价结合
公开(公告)号：EP1322673A1
公开(公告)日：2003-07-02
申请号：EP01972171.1
申请日：2001-09-20
申请人： SANOFI-SYNTHELABO , Akzo Nobel N.V.
IPC分类号： C08B37/00 , A61K31/715
CPC分类号： C08B37/006 , A61K31/715 , C08B37/00 , C08B37/0063
摘要： The invention concerns novel synthetic polysaccharides, with antithrombotic activity, having at least a covalent bond with biotin or a biotin derivative and a method using avidin or streptavidin for neutralising said polysaccharides.
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公开(公告)号：EP1032579B1
公开(公告)日：2003-05-02
申请号：EP98958248.1
申请日：1998-11-16
申请人： Akzo Nobel N.V. , SANOFI-SYNTHELABO
发明人： VAN BOECKEL, Constant, Adriaan, Anton , PETITOU, Maurice , DUCHAUSSOY, Philippe , DREEF-TROMP, Cornelia, Maria , BASTEN, Johannes, Egbertus, Maria
摘要： The invention relates to a carbohydrate derivative having formula (I) wherein R1 is (1-4C)alkoxy; R?2, R3 and R4¿ are independently (1-4C)alkoxy or OSO¿3?-; the total number of sulfate groups is 4, 5 or 6; and the twisted lines represent bonds either above or below the plane of the six-membered ring to which they are attached; or a pharmaceutically acceptable salt thereof. The compounds of the invention have antithrombotic activity and may be used for treating or preventing thrombosis and for inhibiting smooth muscle cell proliferation.
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5.发明授权POLYSACCHARIDES SYNTHETIQUES, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT 失效合成多糖，PROCESS FOR THEIR和含有的药物组合物
公开(公告)号：EP0912613B1
公开(公告)日：2002-09-25
申请号：EP97934596.4
申请日：1997-07-18
申请人： SANOFI-SYNTHELABO , Akzo Nobel N.V.
发明人： DRIGUEZ, Pierre, Alexandre , DUCHAUSSOY, Philippe , HERBERT, Jean-Marc , PETITOU, Maurice , VAN BOECKEL, Constant , GROOTENHUIS, Peter , DREEF-TROMP, Cornélia , BASTEN, Johannes
IPC分类号： C08B37/00 , C07H15/04 , C07H19/01 , A61K31/715
CPC分类号： C08B37/006 , C08B37/00
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6.发明授权
公开(公告)号：EP0904299B1
公开(公告)日：2001-08-29
申请号：EP97928337.1
申请日：1997-06-11
申请人： SANOFI-SYNTHELABO , Akzo Nobel N.V.
发明人： DUCHAUSSOY, Philippe , HERBERT, Jean-Marc , JAURAND, Guy , PETITOU, Maurice , VAN BOECKEL, Constant
IPC分类号： C08B37/00 , A61K31/715
CPC分类号： C08B37/006 , A61K31/435 , A61K31/445 , A61K31/505 , A61K31/60 , A61K31/715 , A61K45/06 , C08B37/00
摘要： Synthetic polysaccharides are disclosed containing 8-24 monosaccharide units made up of a concatenation of disaccharides consisting of a uronic acid and a hexose, wherein the hydroxyl groups of the polysaccharides are etherified with a C1-6 alkyl group or esterified in the form of a sulpho group, each disaccharide being at least monoetherified; and salts thereof, are disclosed.
摘要翻译： 含有8-24个单糖单元的合成多糖，其由糖醛酸和己糖组成的二糖串联组成，其中多糖的所有羟基都被C1-6烷基醚化或磺化为磺基形式 组，每种二糖至少单醚化; 及其盐，被公开。
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7.发明公开POLYSACCHARIDES DE SYNTHESE, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LE CONTENANT 有权合成多糖，PROCESS FOR THEIR和含有药物组合物
公开(公告)号：EP1049721A1
公开(公告)日：2000-11-08
申请号：EP99900524.2
申请日：1999-01-13
申请人： Sanofi-Synthélabo , Akzo Nobel N.V.
发明人： BASTEN, Johannes , DREEF-TROMP, Cornelia , DRIGUEZ, Pierre-Alexandre , DUCHAUSSOY, Philippe , HERBERT, Jean-Marc , PETITOU, Maurice , VAN BOECKEL, Constant
IPC分类号： C08B37/00 , A61K31/725
CPC分类号： C08B37/0063
摘要： The invention relates to synthetic polysaccharides in an acid form and their pharmaceutically acceptable salts, the anionic form of which complies with one of the formulas (I) to (V) described in claim 1. Said polysaccharides can be used in the treatment of diseases linked to coagulation disorders.
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8.发明公开INHIBITEUR DU FACTEUR Xa SEUL OU EN COMBINAISON AVEC UN ANTIAGREGANT PLAQUETTAIRE, CONTRE LA THROMBOSE ARTERIELLE 失效使用的因子的抑制性寡糖WITH A抗凝剂动脉血栓形成的治疗
公开(公告)号：EP0986376A1
公开(公告)日：2000-03-22
申请号：EP98929521.7
申请日：1998-06-09
申请人： Sanofi-Synthélabo , Akzo Nobel N.V.
CPC分类号： A61K31/7024 , A61K31/00 , A61K31/40 , A61K31/435 , A61K31/445 , A61K31/702 , A61K31/715 , A61K45/06 , A61K2300/00
摘要： The invention concerns the use of direct or indirect selective inhibitors of the Xa factor acting via antithrombin III, on their own or combined with one or several compounds with platelet antiaggregating activity, for preparing medicines for preventing or treating arterial thromboembolism. The invention also concerns pharmaceutical compositions containing one or several direct or indirect selective inhibitors of Xa factor acting via antithrombin III in association with one or several compounds with platelet antiaggregating activity, and, optionally one or several pharmaceutically acceptable carriers.
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9.发明公开SYNTHETIC POLYSACCHARIDES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID POLYSACCHARIDES 失效合成多糖，PROCESS FOR THEIR和含有药物组合物
公开(公告)号：EP0904299A1
公开(公告)日：1999-03-31
申请号：EP97928337.0
申请日：1997-06-11
申请人： SANOFI , Akzo Nobel N.V.
发明人： DUCHAUSSOY, Philippe , HERBERT, Jean-Marc , JAURAND, Guy , PETITOU, Maurice , VAN BOECKEL, Constant
CPC分类号： C08B37/006 , A61K31/435 , A61K31/445 , A61K31/505 , A61K31/60 , A61K31/715 , A61K45/06 , C08B37/00
摘要： Synthetic polysaccharides are disclosed containing 8-24 monosaccharide units made up of a concatenation of disaccharides consisting of a uronic acid and a hexose, wherein the hydroxyl groups of the polysaccharides are etherified with a C1-6 alkyl group or esterified in the form of a sulpho group, each disaccharide being at least monoetherified; and salts thereof, are disclosed.
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10.发明公开POLYSACCHARIDES SYNTHETIQUES, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT 失效合成多糖，PROCESS FOR THEIR和含有的药物组合物
公开(公告)号：EP0912613A1
公开(公告)日：1999-05-06
申请号：EP97934596.0
申请日：1997-07-18
申请人： SANOFI , Akzo Nobel N.V.
发明人： DRIGUEZ, Pierre, Alexandre , DUCHAUSSOY, Philippe , HERBERT, Jean-Marc , PETITOU, Maurice , VAN BOECKEL, Constant , GROOTENHUIS, Peter , DREEF-TROMP, Cornélia , BASTEN, Johannes
CPC分类号： C08B37/006 , C08B37/00
摘要： A synthetic polysaccharide including an antithrombin III binding domain consisting of a concatenation of five monosaccharides supporting a total of two carboxylic acid functions and at least four sulpho groups, said domain being directly bound at the non-reducing end by a thrombin binding domain including a concatenation of 10-25 monosaccharide units selected from hexoses, pentoses or deoxy sugars of which all the hydroxyl groups are etherified by a C1-6 alkyl group or esterified in the form of sulpho groups, as well as salts and particularly pharmaceutically acceptable salts thereof, are disclosed.
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