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公开(公告)号：EP2584356A4
公开(公告)日：2013-11-27
申请号：EP11797822
申请日：2011-06-20
发明人： INOUE KEIJI , SHUIN TARO , FURIHATA MUTSUO , HIRAO YOSHIHIKO , TANAKA TOHRU
IPC分类号： G01N33/48 , G01N33/493 , G01N33/58
CPC分类号： G01N21/6486 , A61K41/0061 , A61K49/0021 , A61K49/0036 , G01N21/6428 , G01N21/6458 , G01N33/57407 , G01N33/57434 , G01N33/57438 , G01N33/582
摘要： It is to provide a method for detecting urothelial cancer simply and with high accuracy. It is a method for detecting urothelial cancer comprising administering 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of these to a test subject, collecting urine from the test subject, and detecting the presence of fluorescence or amount of fluorescence in the collected urine.
摘要翻译： 它提供简单且高准确度地检测尿路上皮癌的方法。 它是一种检测泌尿道上皮癌的方法，其包括将5-氨基乙酰丙酸（ALA），其衍生物或它们的盐施用于受试者，从受试者收集尿，并且检测受试者中的荧光或荧光量 收集的尿液。
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2.发明公开TREATMENT AGENT AND/OR PROPHYLACTIC AGENT FOR SIDE EFFECTS OF CANCER DRUGS 审中-公开BEHANDLUNGSMITTEL UND / ODER PROPHYLAKTISCHER WIRKSTOFF GEGEN NEBENWIRKUNGEN VON KREBSMEDIKAMENTEN
公开(公告)号：EP2767277A4
公开(公告)日：2015-04-08
申请号：EP12839452
申请日：2012-10-05
发明人： TANAKA TOHRU , TSUCHIYA KYOKO , ISHIZUKA MASAHIRO , NAKAJIMA MOTOWO , NAKAGAWA HITOSHI , SHUIN TARO , INOUE KEIJI , FUKUHARA HIDEO , TSUDA MASAYUKI , FURIHATA MUTSUO
IPC分类号： A61K31/197 , A61K31/28 , A61K31/295 , A61K33/06 , A61K33/24 , A61K33/26 , A61K33/30 , A61P35/00 , A61P43/00
CPC分类号： A61K31/197 , A61K31/221 , A61K31/28 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/555 , A61K33/06 , A61K33/24 , A61K33/26 , A61K33/30 , A61K45/06 , A61K2300/00
摘要： Problem to be Solved A prophylactic and/or therapeutic agent for side effects of anticancer agent is provided. Solution The present invention provides a prophylactic and/or therapeutic agent for side effects of anticancer agent comprising ALAs.
摘要翻译： 待解决的问题提供了抗癌剂副作用的预防和/或治疗剂。 溶液本发明提供了包含ALA的抗癌剂的副作用的预防和/或治疗剂。
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公开(公告)号：EP3168296A4
公开(公告)日：2017-11-29
申请号：EP15818957
申请日：2015-07-10
CPC分类号： A61K31/197 , A01K67/02 , A61K33/26 , A61K45/06 , A61K2300/00
摘要： It is intended to provide an in vitro culture medium that allows the in vitro culture of fertilized eggs to progress normally to the blastocyst stage without arresting the development thereof. The normal development rate of a fertilized egg is improved by using 5-aminolevulinic acids represented by the following formula (I) (wherein R 1 represents a hydrogen atom or an acyl group, and R 2 represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, an aryl group, or an aralkyl group) or salts thereof as an agent for improving a normal development rate of a fertilized egg.
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公开(公告)号：EP2875812A4
公开(公告)日：2016-02-24
申请号：EP13823261
申请日：2013-07-11
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , ABE FUMINORI , ITO HIDENORI , TAKAHASHI KIWAMU , MATSUSHIMA KOUJI , UEHA SATOSHI , ABE JUN
IPC分类号： A61K31/195 , A61K31/16 , A61K31/197 , A61K31/22 , A61K31/24 , A61K31/555 , A61K33/26 , A61K45/00 , A61K45/06 , A61P7/00 , A61P39/00 , A61P43/00
CPC分类号： A61K31/197 , A61K31/22 , A61K31/24 , A61K31/555 , A61K33/26 , A61K45/06 , A61K2300/00
摘要： An object of the present invention is to provide a preventive and/or therapeutic agent for radiation damage that has a novel mechanism of action and can prevent and alleviate a wide range of symptoms of radiation damage for which no therapeutic measures have been available so far, and moreover, is highly safe to humans. A preventive and/or therapeutic agent for radiation damage comprising a compound represented by the following formula (I) such as 5-aminolevulinic acid (5-ALA) or a salt thereof as an active ingredient can be used to improve the survival rate, improve body weight reduction, and alleviate hematopoietic disorder: (wherein R 1 represents a hydrogen atom or an acyl group; and R 2 represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, an aryl group, or an aralkyl group).
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公开(公告)号：EP2272538A4
公开(公告)日：2014-10-29
申请号：EP09735225
申请日：2009-04-21
发明人： INOUE KEIJI , ISHIZUKA MASAHIRO , TANAKA TOHRU
CPC分类号： A61K49/0021 , A61K41/0061 , Y10S514/814
摘要： Provided is a sensitizing detection agent of an oral or intravenous administration type which enables the detection of bladder cancer with a higher sensitivity without causing pain to the patient. A sensitizing detection agent for bladder cancer comprising 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of these is orally or intravenously administered, and a video camera system is inserted via the urethra and a blue light at 380-440 nm is irradiated to observe the red fluorescent part. Further, VLD-M1 is inserted and a blue light at 405 nm is irradiated to observe fluorescence intensity (relative intensity) of the red light part. For oral administration, 20 mg/kg (maximum of 1 g) of ALA is dissolved in 50 mL of a 5% glucose solution prior to the administration.
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6.发明公开ANTIMALARIAL DRUG WHICH CONTAINS 5-AMINOLEVULINIC ACID OR DERIVATIVE THEREOF AS ACTIVE INGREDIENT 有权MEDIKAMENT GEGEN MALARIA MIT 5-AMINOLEVULINSÄUREODER EINEM DERIVAT DAVON ALS WIRKSTOFF
公开(公告)号：EP2572711A4
公开(公告)日：2013-11-20
申请号：EP11783280
申请日：2011-05-18
发明人： TANAKA TOHRU , KAWATA SATOFUMI , KOHDA TAKEO , NAKAJIMA MOTOWO , KITA KIYOSHI
IPC分类号： A61K31/197 , A61K31/221 , A61K33/06 , A61K33/24 , A61K33/26 , A61K33/30 , A61K45/06 , A61P33/06 , A61P43/00
CPC分类号： A61K31/197 , A61K9/4866 , A61K31/221 , A61K33/06 , A61K33/26 , A61K33/30 , A61K45/06 , A61K2300/00
摘要： Provided is an antimalarial drug which is useful for prevention and treatment of infectious diseases caused by malaria parasites. A preventive and/or therapeutic agent for malaria, which contains, as an active ingredient, 5-aminolevulinic acid (ALA), a derivative thereof, or a pharmacologically acceptable salt thereof, is used.
摘要翻译： 提供了一种抗疟药物，可用于预防和治疗由疟疾寄生虫引起的传染病。 使用含有5-氨基乙酰丙酸（ALA），其衍生物或其药理学上可接受的盐作为活性成分的疟疾预防和/或治疗剂。
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7.发明公开COMPOSITION FOR PREVENTION OR TREATMENT OF TREATMENT-RESISTANT CANCER 审中-公开ZUSAMMENSETZUNG ZUR PREVENTION ODER BEHANDLUNG VON BEHANDLUNGSRESISTENTEM KREBS
公开(公告)号：EP3108884A1
公开(公告)日：2016-12-28
申请号：EP15752334
申请日：2015-02-16
发明人： ISHIKAWA TOSHIHISA , KUROIWA TOSHIHIKO , KAJIMOTO YOSHINAGA , FUJISHIRO TAKAHIRO , KIMURA SEIGO , MIYATAKE SHIN-ICHI , TANAKA TOHRU
CPC分类号： A61K41/0061 , A61K31/22 , A61K31/235 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , A61N5/062 , A61K2300/00
摘要： [Problem to be Solved] It is an object of the present invention to provide a preventive or therapeutic composition for a therapy-resistant cancer having therapy-resistant cancer cells. [Solution] A preventive or therapeutic composition for a therapy-resistant cancer having therapy-resistant cancer cells, which is for use in photodynamic therapy, wherein the composition comprises ALAs.
摘要翻译： [待解决的问题]本发明的目的是提供具有耐药性癌细胞的耐药性癌症的预防或治疗组合物。 [解决方案]一种用于治疗耐药性癌症的预防或治疗组合物，其具有治疗抗性癌细胞，其用于光动力学治疗，其中所述组合物包含ALA。
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公开(公告)号：EP2875813A4
公开(公告)日：2016-04-20
申请号：EP13819512
申请日：2013-06-03
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , TAKAHASHI KIWAMU , ISHII TAKUYA , KIDO HIROSHI , CHIDA JUNJI , YAMANE KAZUHIKO
IPC分类号： A61K31/197 , A61K33/26 , A61P31/16 , A61P43/00
CPC分类号： A61K31/197 , A61K31/194 , A61K33/26 , A61K45/06 , A61K2300/00
摘要： Provided is a prophylactic/therapeutic agent for influenza viral infection that is effective not only before and at an early stage of infection with influenza virus but also at an intermediate or late stage of the infection and is highly safe for human bodies. A prophylactic/therapeutic drug for influenza viral infection comprising, as active ingredients, 5-aminolevulinic acid (5-ALA), a derivative thereof or a salt of the 5-ALA or the derivative, and an iron compound is prepared. This prophylactic/therapeutic agent can be used for ameliorating (preventing) depression in food consumption, water consumption and body weight, for ameliorating (decreasing) increase in ketone body levels in blood that may otherwise cause ketosis, for ameliorating (preventing) depression in ATP levels in blood, or for ameliorating (increasing) a survival rate and depression in a body surface temperature.
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9.发明公开PHOTODYNAMIC THERAPY USING PHOTOSENSITIZING AGENT OR 5-AMINOLEVULINIC ACID 审中-公开光动力疗法WITH A FOTOSENSIBILATOR OR 5-氨基乙酰丙酸
公开(公告)号：EP2727603A4
公开(公告)日：2015-03-04
申请号：EP12807976
申请日：2012-06-20
发明人： TANAKA TOHRU , INOUE KATSUSHI , ISHII TAKUYA , YOSHIDA TAKATO
CPC分类号： A61N5/062 , A61K31/197 , A61K41/0061 , A61K41/0071 , A61K49/0052
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公开(公告)号：EP3150067A4
公开(公告)日：2017-11-08
申请号：EP15799853
申请日：2015-02-24
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , OTA URARA , ITO HIDENORI , RII KO
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/02
摘要： Provided is an organ preservation solution for use in transplantation, which is capable of effectively preventing the occurrence of ischemia-reperfusion injury. Prepared is an organ preservation solution comprising a mixture of the following components: (a) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, and D-glucose; (b) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, glycine, and D-glucose; (c) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, L-cysteine, glycine, and D-glucose; or (d) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, L-cysteine, glycine, an iron compound, and D-glucose.
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