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公开(公告)号：EP3168296A4
公开(公告)日：2017-11-29
申请号：EP15818957
申请日：2015-07-10
CPC分类号： A61K31/197 , A01K67/02 , A61K33/26 , A61K45/06 , A61K2300/00
摘要： It is intended to provide an in vitro culture medium that allows the in vitro culture of fertilized eggs to progress normally to the blastocyst stage without arresting the development thereof. The normal development rate of a fertilized egg is improved by using 5-aminolevulinic acids represented by the following formula (I) (wherein R 1 represents a hydrogen atom or an acyl group, and R 2 represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, an aryl group, or an aralkyl group) or salts thereof as an agent for improving a normal development rate of a fertilized egg.
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公开(公告)号：EP2875812A4
公开(公告)日：2016-02-24
申请号：EP13823261
申请日：2013-07-11
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , ABE FUMINORI , ITO HIDENORI , TAKAHASHI KIWAMU , MATSUSHIMA KOUJI , UEHA SATOSHI , ABE JUN
IPC分类号： A61K31/195 , A61K31/16 , A61K31/197 , A61K31/22 , A61K31/24 , A61K31/555 , A61K33/26 , A61K45/00 , A61K45/06 , A61P7/00 , A61P39/00 , A61P43/00
CPC分类号： A61K31/197 , A61K31/22 , A61K31/24 , A61K31/555 , A61K33/26 , A61K45/06 , A61K2300/00
摘要： An object of the present invention is to provide a preventive and/or therapeutic agent for radiation damage that has a novel mechanism of action and can prevent and alleviate a wide range of symptoms of radiation damage for which no therapeutic measures have been available so far, and moreover, is highly safe to humans. A preventive and/or therapeutic agent for radiation damage comprising a compound represented by the following formula (I) such as 5-aminolevulinic acid (5-ALA) or a salt thereof as an active ingredient can be used to improve the survival rate, improve body weight reduction, and alleviate hematopoietic disorder: (wherein R 1 represents a hydrogen atom or an acyl group; and R 2 represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, an aryl group, or an aralkyl group).
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公开(公告)号：EP2875813A4
公开(公告)日：2016-04-20
申请号：EP13819512
申请日：2013-06-03
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , TAKAHASHI KIWAMU , ISHII TAKUYA , KIDO HIROSHI , CHIDA JUNJI , YAMANE KAZUHIKO
IPC分类号： A61K31/197 , A61K33/26 , A61P31/16 , A61P43/00
CPC分类号： A61K31/197 , A61K31/194 , A61K33/26 , A61K45/06 , A61K2300/00
摘要： Provided is a prophylactic/therapeutic agent for influenza viral infection that is effective not only before and at an early stage of infection with influenza virus but also at an intermediate or late stage of the infection and is highly safe for human bodies. A prophylactic/therapeutic drug for influenza viral infection comprising, as active ingredients, 5-aminolevulinic acid (5-ALA), a derivative thereof or a salt of the 5-ALA or the derivative, and an iron compound is prepared. This prophylactic/therapeutic agent can be used for ameliorating (preventing) depression in food consumption, water consumption and body weight, for ameliorating (decreasing) increase in ketone body levels in blood that may otherwise cause ketosis, for ameliorating (preventing) depression in ATP levels in blood, or for ameliorating (increasing) a survival rate and depression in a body surface temperature.
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公开(公告)号：EP3011972A4
公开(公告)日：2017-03-01
申请号：EP14814295
申请日：2014-06-13
发明人： ISHIZUKA MASAHIRO , OTA URARA , KAMIYA ATSUKO , TAKAHASHI KIWAMU , TANAKA TOHRU , OZAWA TOSHIYUKI , MORIMOTO KUNIYUKI , WATANABE KEITARO
IPC分类号： A61K41/00 , A61K31/19 , A61K31/194 , A61K31/198 , A61K31/375 , A61K33/40 , A61K45/00 , A61P31/04 , A61P43/00
CPC分类号： A61K41/0061 , A61K31/16 , A61K31/194 , A61K31/197 , A61K31/198 , A61K31/375 , A61K33/40 , A61K45/06 , A61K2300/00
摘要： The object of the present invention is to elucidate the resistance mechanism in infections that show resistance to ALA-PDT that uses a single ALA, and to provide a novel treatment method against these infections. The present invention provides a pharmaceutical composition for promoting protoporphyrin IX production in ALA-PDT for treating infection, characterized in that it comprises a substance that promotes the conversion from coproporphyrinogen III to protoporphyrin IX.
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公开(公告)号：EP2767280A4
公开(公告)日：2015-04-08
申请号：EP12840143
申请日：2012-10-05
IPC分类号： A61K31/197 , A61K31/28 , A61K31/295 , A61K33/06 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/34 , A61P7/06 , A61P35/00 , A61P43/00
CPC分类号： A61K31/195 , A61K31/197 , A61K31/216 , A61K31/222 , A61K31/295 , A61K33/06 , A61K33/26 , A61K33/30 , A61K2300/00 , A61K31/22
摘要： Problem to be Solved An agent for ameliorating and/or preventing anemia, which is useful in the amelioration and/or prevention of cancerous anemia, and can improve the quality of life of a cancerous anemia patient without advancing cancer progression, is provided. Solution An agent for ameliorating and/or preventing cancerous anemia containing 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt thereof is prepared. Preferably, a metal-containing compound such as sodium ferrous citrate is contained in these ALAs. As the above-mentioned ALAs, ALA; various esters such as ALA methylester, ALA ethylester, ALA propylester, ALA butylester, and ALA pentylester; and hydrochlorides, phosphates, and sulfates, and the like of these ALA esters can be preferably exemplified.
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公开(公告)号：EP2745838A4
公开(公告)日：2015-03-18
申请号：EP12824258
申请日：2012-08-10
发明人： KINOSHITA KOSAKU , TANJOH KATSUHISA , NODA AKIHIRO , SAKURAI ATSUSHI , TANAKA TOHRU , TAKAHASHI KIWAMU , NAKAJIMA MOTOWO , ABE FUMINORI
IPC分类号： A61K31/197 , A61K31/28 , A61K31/295 , A61K33/06 , A61K33/26 , A61K33/30 , A61K33/34 , A61P31/04 , A61P43/00
CPC分类号： A61K33/26 , A61K31/197 , A61K31/28 , A61K31/295 , A61K45/06
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公开(公告)号：EP2873417A4
公开(公告)日：2016-03-09
申请号：EP13816500
申请日：2013-07-03
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , ABE FUMINORI , HAGA NAOMI , TAKAHASHI KIWAMU , ITO HIDENORI , RII KO
IPC分类号： A61K31/197 , A61K31/194 , A61K33/26 , A61K38/19 , A61P17/00 , A61P37/06 , A61P37/08
CPC分类号： A61K31/197 , A61K31/194 , A61K33/26 , A61K38/193 , A61K38/40 , C12N5/064 , C12N2500/24 , C12N2501/052 , C12N2501/22 , C12N2501/2304 , A61K2300/00
摘要： An object of the present invention is to provide a regulatory dendritic cell inducing agent applicable to the treatment of immune disease as well as an immune tolerance inducing agent such as a preventive and/or therapeutic agent for allergic disease and a preventive and/or therapeutic agent for autoimmune disease, both of which are safe and have the mechanism of action different from that of conventional drugs. As a means for achieving the above object, an immune tolerance inducing agent comprising 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of the 5-ALA or the derivative and an iron compound as active ingredients is prepared. Preferable examples of the ALAs can include ALA and various esters such as methyl ester, ethyl ester, propyl ester, butyl ester, and pentyl ester of ALA, and their hydrochlorides, phosphates, and sulfates. Preferable examples of the iron compound can include sodium ferrous citrate.
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公开(公告)号：EP2767279A4
公开(公告)日：2015-05-06
申请号：EP12839684
申请日：2012-10-05
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , TAKAHASHI KIWAMU , ABE TAKAAKI
IPC分类号： A61K31/197 , A61K31/28 , A61K31/295 , A61K33/06 , A61K33/26 , A61K33/30 , A61P7/06 , A61P13/12
CPC分类号： C07C217/08 , A61K31/195 , A61K31/197 , A61K31/221 , A61K31/28 , A61K31/295 , A61K33/06 , A61K33/26 , A61K33/30 , A61K45/06
摘要： Problem to be Solved The present invention provides a therapeutic agent and/or prophylactic agent for renal anemia. The present invention also provides an erythropoietin production promoter. Solution The present invention provides a therapeutic and/or prophylactic agent for renal anemia comprising ALAs. The present invention also provides an erythropoietin production promoter comprising ALAs.
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公开(公告)号：EP2767278A4
公开(公告)日：2015-04-08
申请号：EP12839496
申请日：2012-09-12
发明人： RII KO , TAKAHASHI KIWAMU , HAGA NAOMI , ABE FUMINORI , TANAKA TOHRU , NAKAJIMA MOTOWO , ITO HIDENORI
IPC分类号： A61K31/197 , A61K31/22 , A61K31/295 , A61K33/26 , A61P37/06
CPC分类号： A61K31/197 , A01N1/0226 , A61K31/22 , A61K31/295 , A61K33/26 , A61K35/17 , A61K45/06 , A61K2035/122 , A61K2035/124 , A61K2300/00
摘要： The present invention provides an agent for promoting graft survival which can suppress rejection without use of existing immunosuppressants, an organ preservation solution capable of maintaining the freshness of an organ excised from a donor, and the like. An agent for promoting graft survival or an organ preservation solution is prepared, which comprises 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of ALA or the derivative and an iron compound as active ingredients. Preferable examples of the ALAs can include ALA and various esters such as methyl ester, ethyl ester, propyl ester, butyl ester, and pentyl ester of ALA, and their hydrochlorides, phosphates, and sulfates. Preferable examples of the iron compound can include sodium ferrous citrate.
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公开(公告)号：EP2617416A4
公开(公告)日：2014-01-22
申请号：EP11824763
申请日：2011-09-12
IPC分类号： A61K31/197 , A61P35/00 , A61P43/00
CPC分类号： C07C229/22 , A61K31/197
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