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公开(公告)号：EP2875812A4
公开(公告)日：2016-02-24
申请号：EP13823261
申请日：2013-07-11
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , ABE FUMINORI , ITO HIDENORI , TAKAHASHI KIWAMU , MATSUSHIMA KOUJI , UEHA SATOSHI , ABE JUN
IPC分类号： A61K31/195 , A61K31/16 , A61K31/197 , A61K31/22 , A61K31/24 , A61K31/555 , A61K33/26 , A61K45/00 , A61K45/06 , A61P7/00 , A61P39/00 , A61P43/00
CPC分类号： A61K31/197 , A61K31/22 , A61K31/24 , A61K31/555 , A61K33/26 , A61K45/06 , A61K2300/00
摘要： An object of the present invention is to provide a preventive and/or therapeutic agent for radiation damage that has a novel mechanism of action and can prevent and alleviate a wide range of symptoms of radiation damage for which no therapeutic measures have been available so far, and moreover, is highly safe to humans. A preventive and/or therapeutic agent for radiation damage comprising a compound represented by the following formula (I) such as 5-aminolevulinic acid (5-ALA) or a salt thereof as an active ingredient can be used to improve the survival rate, improve body weight reduction, and alleviate hematopoietic disorder: (wherein R 1 represents a hydrogen atom or an acyl group; and R 2 represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, an aryl group, or an aralkyl group).
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2.发明公开ANTIMALARIAL DRUG WHICH CONTAINS 5-AMINOLEVULINIC ACID OR DERIVATIVE THEREOF AS ACTIVE INGREDIENT 有权MEDIKAMENT GEGEN MALARIA MIT 5-AMINOLEVULINSÄUREODER EINEM DERIVAT DAVON ALS WIRKSTOFF
公开(公告)号：EP2572711A4
公开(公告)日：2013-11-20
申请号：EP11783280
申请日：2011-05-18
发明人： TANAKA TOHRU , KAWATA SATOFUMI , KOHDA TAKEO , NAKAJIMA MOTOWO , KITA KIYOSHI
IPC分类号： A61K31/197 , A61K31/221 , A61K33/06 , A61K33/24 , A61K33/26 , A61K33/30 , A61K45/06 , A61P33/06 , A61P43/00
CPC分类号： A61K31/197 , A61K9/4866 , A61K31/221 , A61K33/06 , A61K33/26 , A61K33/30 , A61K45/06 , A61K2300/00
摘要： Provided is an antimalarial drug which is useful for prevention and treatment of infectious diseases caused by malaria parasites. A preventive and/or therapeutic agent for malaria, which contains, as an active ingredient, 5-aminolevulinic acid (ALA), a derivative thereof, or a pharmacologically acceptable salt thereof, is used.
摘要翻译： 提供了一种抗疟药物，可用于预防和治疗由疟疾寄生虫引起的传染病。 使用含有5-氨基乙酰丙酸（ALA），其衍生物或其药理学上可接受的盐作为活性成分的疟疾预防和/或治疗剂。
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公开(公告)号：EP3064202A4
公开(公告)日：2017-03-29
申请号：EP14858331
申请日：2014-10-22
发明人： CHIBAZAKURA TAKU , TANAKA TOHRU , ABE FUMINORI , NAKAJIMA MOTOWO , KAMIYA ATSUKO , HAGA NAOMI , TAKAHASHI KIWAMU
IPC分类号： A61K31/197 , A61P7/00 , A61P7/06 , A61P25/00 , A61P43/00
CPC分类号： A61K31/197
摘要： The object of the present invention to provide an agent effective for treating and preventing e.g. a disease caused by reduction in frataxin production. The present invention provides a frataxin enhancer comprising 5-aminolevulinic acid (ALA) or a derivative thereof or salts thereof, as well as a therapeutic and/or prophylactic agent for a disease caused by reduction in frataxin production.
摘要翻译： 本发明的目的是提供有效治疗和预防例如 一种由frataxin生产减少引起的疾病。 本发明提供了包含5-氨基乙酰丙酸（ALA）或其衍生物或其盐，以及由减少frataxin产生引起的疾病的治疗剂和/或预防剂的frataxin增强剂。
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公开(公告)号：EP2617416A4
公开(公告)日：2014-01-22
申请号：EP11824763
申请日：2011-09-12
IPC分类号： A61K31/197 , A61P35/00 , A61P43/00
CPC分类号： C07C229/22 , A61K31/197
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公开(公告)号：EP2875813A4
公开(公告)日：2016-04-20
申请号：EP13819512
申请日：2013-06-03
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , TAKAHASHI KIWAMU , ISHII TAKUYA , KIDO HIROSHI , CHIDA JUNJI , YAMANE KAZUHIKO
IPC分类号： A61K31/197 , A61K33/26 , A61P31/16 , A61P43/00
CPC分类号： A61K31/197 , A61K31/194 , A61K33/26 , A61K45/06 , A61K2300/00
摘要： Provided is a prophylactic/therapeutic agent for influenza viral infection that is effective not only before and at an early stage of infection with influenza virus but also at an intermediate or late stage of the infection and is highly safe for human bodies. A prophylactic/therapeutic drug for influenza viral infection comprising, as active ingredients, 5-aminolevulinic acid (5-ALA), a derivative thereof or a salt of the 5-ALA or the derivative, and an iron compound is prepared. This prophylactic/therapeutic agent can be used for ameliorating (preventing) depression in food consumption, water consumption and body weight, for ameliorating (decreasing) increase in ketone body levels in blood that may otherwise cause ketosis, for ameliorating (preventing) depression in ATP levels in blood, or for ameliorating (increasing) a survival rate and depression in a body surface temperature.
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公开(公告)号：EP3168296A4
公开(公告)日：2017-11-29
申请号：EP15818957
申请日：2015-07-10
CPC分类号： A61K31/197 , A01K67/02 , A61K33/26 , A61K45/06 , A61K2300/00
摘要： It is intended to provide an in vitro culture medium that allows the in vitro culture of fertilized eggs to progress normally to the blastocyst stage without arresting the development thereof. The normal development rate of a fertilized egg is improved by using 5-aminolevulinic acids represented by the following formula (I) (wherein R 1 represents a hydrogen atom or an acyl group, and R 2 represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, an aryl group, or an aralkyl group) or salts thereof as an agent for improving a normal development rate of a fertilized egg.
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公开(公告)号：EP3150067A4
公开(公告)日：2017-11-08
申请号：EP15799853
申请日：2015-02-24
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , OTA URARA , ITO HIDENORI , RII KO
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/02
摘要： Provided is an organ preservation solution for use in transplantation, which is capable of effectively preventing the occurrence of ischemia-reperfusion injury. Prepared is an organ preservation solution comprising a mixture of the following components: (a) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, and D-glucose; (b) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, glycine, and D-glucose; (c) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, L-cysteine, glycine, and D-glucose; or (d) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, L-cysteine, glycine, an iron compound, and D-glucose.
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公开(公告)号：EP2789336A4
公开(公告)日：2015-05-27
申请号：EP12854923
申请日：2012-11-30
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , ABE FUMINORI , KAWATA SATOFUMI
IPC分类号： A61K31/197 , A61K31/28 , A61K33/06 , A61K33/14 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/34 , A61P3/00
CPC分类号： A61K31/197 , A61K9/48 , A61K31/194 , A61K31/198 , A61K31/295 , A61K31/315 , A61K31/525 , A61K33/04 , A61K33/24 , A61K33/26 , A61K33/30 , C07C229/22 , A61K2300/00
摘要： The object of the present invention is to provide a hangover prophylactic and/or therapeutic agent. The present invention provides a hangover prophylactic and/or therapeutic agent comprising ALAs.
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9.发明公开
公开(公告)号：EP2835094A4
公开(公告)日：2016-03-09
申请号：EP13773042
申请日：2013-03-27
发明人： INOUE KATSUSHI , TANAKA TOHRU , ISHII TAKUYA , NAKAJIMA MOTOWO
CPC分类号： A61B5/418 , A61B1/00165 , A61B1/043 , A61B5/0071 , A61B5/0084 , A61B10/0041 , F04C2270/041 , G01N2021/6484
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公开(公告)号：EP2767276A4
公开(公告)日：2015-05-06
申请号：EP12839430
申请日：2012-10-05
发明人： TANAKA TOHRU , NAKAJIMA MOTOWO , ABE FUMINORI , KAWATA SATOFUMI , KOHDA TAKEO
IPC分类号： A61K31/197 , A61K31/28 , A61K31/295 , A61K33/06 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/34 , A61P13/12 , A61P43/00
CPC分类号： C07C229/22 , A61K31/197 , A61K31/215 , A61K31/28 , A61K31/295 , A61K33/24 , A61K33/26 , A61K33/28 , A61K33/30 , A61K33/34 , C07F15/02 , A61K2300/00
摘要： Problem to be Solved An agent for ameliorating chronic kidney disease which is not an existing symptomatic therapeutic drug for chronic kidney disease, and which can increase the eGFR value and can improve renal function per se is provided. Solution An agent for ameliorating and/or preventing chronic kidney disease containing 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt thereof as an active ingredient is prepared. Preferably, a metal-containing compound such as sodium ferrous citrate is contained in these ALAs. As the above-mentioned ALAs, ALA; various esters such as ALA methylester, ALA ethylester, ALA propylester, ALA butylester, and ALA pentylester; and hydrochlorides, phosphates, and sulfates, and the like of these ALA esters can be preferably exemplified.
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