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1.发明公开TREATMENT OF URINARY INCONTINENCE WITH NITRIC OXIDE SYNTHASE SUBSTRATES AND/OR NITRIC OXIDE DONORS 失效尿失禁用氮气氧化氮合酶衬底及/或治疗DONORS
公开(公告)号：EP0874627A1
公开(公告)日：1998-11-04
申请号：EP97902990.0
申请日：1997-01-21
CPC分类号： A61K31/566 , A61K31/198 , A61K31/21 , A61K31/295 , A61K31/34 , A61K31/56 , A61K31/565 , A61K31/569 , A61K31/57 , A61K31/575 , A61K2300/00
摘要： The invention provides a method for the treatment and prevention of urinary incontinence in mammals, e.g., human males and females, especially nonpregnant female mammals, by administering a nitric oxide synthase substrate and/or nitric oxide donor, alone or in combination with an estrogenic agent and/or a progestational substance, with or without supplementation with an alpha-adrenergic agonist, beta-adrenergic receptor blocking agent, cholinergic-receptor blocking compound or a cholinergic-receptor-stimulating drug, as well as pharmaceutical compositions useful in practicing the methods of this invention.
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公开(公告)号：EP0938258A1
公开(公告)日：1999-09-01
申请号：EP97921269.0
申请日：1997-04-16
CPC分类号： A61K9/0026 , A61K33/00 , Y10S514/832 , Y10S514/833
摘要： The present invention involves perfluoro compound emulsions including nitric oxide, their preparation and their use. These emulsions provide a new source of nitric oxide. Such nitric oxide-containing emulsions maybe used for the administration of nitric oxide to individuals in need thereof. Individuals in need of nitric oxide administration can include those suffering from hypertension, preeclampsia and a number of other situations where an increased blood flow, for example, is desirable. In addition, given the long use of perfluoro compound emulsions as blood substitutes, the present invention provides a relatively safe mode for administering and distributing nitric oxide, (see Figure 1) - without potential negative side effects such as toxicities due to drug metabolites.
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3.发明公开TREATMENT OF CLIMACTERIC DISORDERS WITH NITRIC OXIDE SYNTHASE SUBSTRATES AND/OR DONORS 失效用硝酸衬底和/或DONORS更年期症状治疗
公开(公告)号：EP0730445A1
公开(公告)日：1996-09-11
申请号：EP95900760.0
申请日：1994-11-17
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/198 , A61K31/295 , A61K31/341 , A61K31/57 , A61K31/60 , Y10S514/899 , A61K31/41 , A61K31/34 , A61K31/21 , A61K2300/00 , A61K31/557 , A61K31/26
摘要： The symptoms of the climacterium are ameliorated by the administration to an afflicted individual one or both of a nitric oxide substrate and/or nitric acid donor, alone or optionally in combination with a progestin or, in the case of non-pregnant female, either a progestin or an estrogen or both.
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4.发明公开
公开(公告)号：EP0790827A2
公开(公告)日：1997-08-27
申请号：EP95935145.0
申请日：1995-09-22
CPC分类号： A61K31/566 , A61K31/565 , A61K31/567 , A61K31/57 , A61K31/5585 , A61K2300/00
摘要： Cardiovascular disease, including preeclampsia in pregnant women and hypertension in both women and men, are prevented or treated by administering thereto prostacyclin or a prostacyclin analog in combination with one or both of an estrogen and a progestin, which combination is also useful for HRT in peri- and post-menopausal women.
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