公开(公告)号：EP1885726A2

公开(公告)日：2008-02-13

申请号：EP06759539.7

申请日：2006-05-11

申请人： Schering Corporation

发明人： PALANI, Anandan ,  SU, Jing ,  XIAO, Dong ,  HUANG, Xianhai ,  RAO, Ashwin, U. ,  CHEN, Xiao ,  TANG, Haiqun ,  QIN, Jun ,  HUANG, Ying ,  ASLANIAN, Robert, G. ,  MCKITTRICK, Brian

IPC分类号： C07D491/04

CPC分类号： C07D471/04 ,  C07D491/04 ,  C07D491/052

摘要： A compound having the general structure of Formula (I): Formula (I) or a pharmaceutically acceptable salt, solvate, ester, or tautomer thereof, wherein: Q is selected from the group consisting of: Formula (a), (b), (c), (d) and (e); and L is selected from the group consisting of: Formula (f), (g), (h), and (i); or a pharmaceutically acceptable salt, solvate, ester, or tautomer thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome and dyslipidemia.

公开(公告)号：EP0927170A1

公开(公告)日：1999-07-07

申请号：EP97938490.0

申请日：1997-08-28

申请人： SCHERING CORPORATION

发明人： SHUE, Ho-Jane ,  SHIH, Neng-Yang ,  BLYTHIN, David, J. ,  CHEN, Xiao ,  PIWINSKI, John, J. ,  MCCORMICK, Kevin, D.

IPC分类号： C07D487 ,  A61K31 ,  A61P1 ,  A61P9 ,  A61P11 ,  A61P13 ,  A61P15 ,  A61P25 ,  A61P27 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07D241 ,  C07D401 ,  C07D403 ,  C07D405 ,  C07D409 ,  C07D413 ,  C07D417 ,  C07D453 ,  C07D471

CPC分类号： C07D401/06 ,  C07D241/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D453/02 ,  C07D487/04

摘要： The invention relates to compounds of formula (I). These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

公开(公告)号：EP0823906B1

公开(公告)日：2003-07-09

申请号：EP96915342.8

申请日：1996-05-01

申请人： SCHERING CORPORATION

发明人： SHUE, Ho-Jane ,  SHIH, Neng-Yang ,  BLYTHIN, David, J. ,  CHEN, Xiao ,  TOM, Wing, C. ,  PIWINSKI, John, J. ,  MCCORMICK, Kevin, D.

IPC分类号： C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D401/14 ,  C07D453/02 ,  C07D487/04 ,  A61K31/445

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D453/02 ,  C07D487/04 ,  C07D487/10

摘要： The invention relates to compounds of formula (I). These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

摘要翻译： 本发明涉及式（I）的化合物。 这些化合物是神经激肽拮抗剂。 这些化合物可用于治疗慢性气道疾病，如哮喘。

公开(公告)号：EP0850236B1

公开(公告)日：2001-07-04

申请号：EP96931188.5

申请日：1996-08-29

申请人： SCHERING CORPORATION

发明人： SHUE, Ho-Jane ,  SHIH, Neng-Yang ,  BLYTHIN, David, J. ,  CHEN, Xiao ,  PIWINSKI, John, J. ,  MCCORMICK, Kevin, D.

IPC分类号： C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D401/14 ,  C07D453/02 ,  C07D487/04 ,  A61K31/445

CPC分类号： C07D241/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D453/02 ,  C07D487/04

摘要： The invention relates to compounds of formula (I) wherein Z, Rc, y, m, u, Ar2, n, X, Rc',(I) and Ar2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

摘要翻译： 本发明涉及式（I）的化合物，其中Z，R c，y，m，u，Ar 2，n，X，R c'，（I）和Ar 2如本文所述。 这些化合物是神经激肽拮抗剂。 这些化合物可用于治疗慢性气道疾病，如哮喘。

公开(公告)号：EP2379564A1

公开(公告)日：2011-10-26

申请号：EP09796228.6

申请日：2009-12-18

申请人： Schering Corporation

发明人： PALANI, Anandan ,  RAO, Ashwin, U. ,  CHEN, Xiao ,  SHAO, Ning ,  HUANG, Ying, R. ,  ASLANIAN, Robert, G.

IPC分类号： C07D498/04 ,  C07D513/04 ,  A61K31/437 ,  A61P3/10

CPC分类号： C07D513/04 ,  C07D498/04

摘要： The present invention relates to novel Bicyclic Heterocyclic Derivatives, pharmaceutical compositions comprising the Bicyclic Heterocyclic Derivatives and the use of these compounds for treating or preventing treating allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a cognitive disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.

公开(公告)号：EP1828188A1

公开(公告)日：2007-09-05

申请号：EP05849677.9

申请日：2005-12-07

申请人： Schering Corporation

发明人： XIAO, Dong ,  PALANI, Anandan ,  WANG, Cheng ,  TSUI, Hon-chung ,  HUANG, Xianhai ,  SHAH, Sapna S. ,  RAO, Ashwin U. ,  CHEN, Xiao ,  PALIWAL, Sunil ,  SHIH, Neng-yang

IPC分类号： C07D471/18 ,  C07D498/18 ,  C07D471/22 ,  C07D498/22 ,  A61K31/48 ,  A61K31/4375 ,  A61P25/22

CPC分类号： C07D471/08

摘要： A compound having the general structure shown in Formula (I): or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

公开(公告)号：EP0937069B1

公开(公告)日：2006-05-03

申请号：EP97912827.9

申请日：1997-10-28

申请人： SCHERING CORPORATION

发明人： BLYTHIN, David, J. ,  CHEN, Xiao ,  FRIARY, Richard, J. ,  McCORMICK, Kevin, D. ,  PIWINSKI, John, J. ,  SHIH, Neng-Yang ,  SHUE, Ho-Jane

IPC分类号： C07D403/12 ,  C07D417/14 ,  C07D487/08 ,  C07D401/12 ,  C07D401/14 ,  C07D453/06 ,  C07D471/08 ,  C07D409/12 ,  C07D413/14 ,  C07D451/06 ,  C07D451/04

CPC分类号： C07D451/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D451/06 ,  C07D453/06 ,  C07D471/08 ,  C07D487/08

摘要： The invention relates to compounds of formula (I) wherein Z, Rc, y, m, u, Ar2, n, X, Rc', l and Ar2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

摘要翻译： 本发明涉及式（I）的化合物，其中Z，R c，y，m，u，Ar 2，n，X，R c'，l和Ar 2如本文所述。 这些化合物是神经激肽拮抗剂。 这些化合物可用于治疗慢性气道疾病，如哮喘。

公开(公告)号：EP0823906A1

公开(公告)日：1998-02-18

申请号：EP96915342.0

申请日：1996-05-01

申请人： SCHERING CORPORATION

发明人： SHUE, Ho-Jane ,  SHIH, Neng-Yang ,  BLYTHIN, David, J. ,  CHEN, Xiao ,  TOM, Wing, C. ,  PIWINSKI, John, J. ,  MCCORMICK, Kevin, D.

IPC分类号： C07D487 ,  A61K31 ,  A61P1 ,  A61P9 ,  A61P11 ,  A61P13 ,  A61P15 ,  A61P25 ,  A61P27 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07D401 ,  C07D403 ,  C07D405 ,  C07D409 ,  C07D453

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D453/02 ,  C07D487/04 ,  C07D487/10

摘要： The invention relates to compounds of formula (I). These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

公开(公告)号：EP2350067A2

公开(公告)日：2011-08-03

申请号：EP09740590.6

申请日：2009-10-14

申请人： Schering Corporation

发明人： PALANI, Anandan ,  BERLIN, Michael, Y. ,  ASLANIAN, Robert, G. ,  VACCARO, Henry, M. ,  CHAN, Tin-Yau ,  XIAO, Dong ,  DEGRADO, Sylvia ,  RAO, Ashwin, U. ,  CHEN, Xiao ,  LEE, Yoon, Joo ,  SOFOLARIDES, Michael, J. ,  SHAO, Ning ,  HUANG, Ying, R. ,  LIU, Zhidan ,  WANG, Li Yuan ,  PU, Haiyan

IPC分类号： C07D417/04 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D285/135 ,  C07D271/113 ,  C07D491/107 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61P3/10

CPC分类号： C07D285/135 ,  C07D271/113 ,  C07D417/04 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/107

摘要： The present invention relates to novel Pyrrolidine, Piperidine and Piperazine Derivatives, pharmaceutical compositions comprising the Pyrrolidine, Piperidine and Piperazine Derivatives and the use of these compounds for treating or preventing treating allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disoder, a metabolic disorder, obesity, an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.

公开(公告)号：EP2350048A2

公开(公告)日：2011-08-03

申请号：EP09744830.2

申请日：2009-10-14

申请人： Schering Corporation

发明人： PALANI, Anandan ,  XIAO, Dong ,  ASLANIAN, Robert, G. ,  BERLIN, Michael, Y. ,  RAO, Ashwin, U. ,  CHEN, Xiao ,  LEE, Yoon, Joo ,  DEGRADO, Sylvia ,  SHAO, Ning ,  HUANG, Ying, R. ,  LIU, Zhidan

IPC分类号： C07D401/12 ,  A61K31/4427 ,  A61P7/12

CPC分类号： C07D401/06 ,  C07D213/643 ,  C07D213/81 ,  C07D401/12 ,  C07D417/04

摘要： The present invention relates to Azine Derivatives, pharmaceutical compositions comprising the Azine Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.