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1.发明授权TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环衍生物如适用G-蛋白抑制剂和增生性疾病的治疗
公开(公告)号：EP0819121B1
公开(公告)日：2007-05-30
申请号：EP96912469.2
申请日：1996-04-03
发明人： AFONSO, Adriano , BALDWIN, John, J. , DOLL, Ronald, J. , LI, Ge , MALLAMS, Alan, K. , NJOROGE, F., George , RANE, Dinanath, F. , READER, John, C. , ROSSMAN, Randall, R.
IPC分类号： C07D221/16 , A61K31/435 , C07D401/04 , C07D491/04 , C07D405/12 , C07D401/12
CPC分类号： C07D401/04 , C07D221/16 , C07D401/12 , C07D491/04
摘要： Novel compounds of Formula (1.0) are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
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2.发明授权
公开(公告)号：EP0819128B1
公开(公告)日：2002-07-10
申请号：EP96911439.6
申请日：1996-04-03
申请人： SCHERING CORPORATION
发明人： DOLL, Ronald, J. , MALLAMS, Alan, K. , AFONSO, Adriano , RANE, Dinanath, F. , NJOROGE, F., George , ROSSMAN, Randall, R.
IPC分类号： C07D471/04 , A61K31/55 , C07D403/06 , C07D401/12
CPC分类号： C07D401/12 , C07D471/04
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3.发明授权
公开(公告)号：EP0819120B1
公开(公告)日：2003-06-04
申请号：EP96911442.0
申请日：1996-04-03
申请人： SCHERING CORPORATION
发明人： DOLL, Ronald, J. , MALLAMS, Alan, K. , AFONSO, Adriano , RANE, Dinanath, F. , ROSSMAN, Randall, R. , NJOROGE, F., George
IPC分类号： C07D221/16 , A61K31/55 , A61K31/435 , A61K31/495 , C07D401/14 , C07D491/04 , C07D211/32 , C07D401/12 , C07D409/12
CPC分类号： C07D401/12 , C07D211/32 , C07D221/16 , C07D401/14 , C07D409/12 , C07D491/04
摘要： Novel compounds of Formula (1.0) are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of Formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
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4.发明公开
公开(公告)号：EP0819128A1
公开(公告)日：1998-01-21
申请号：EP96911439.0
申请日：1996-04-03
申请人： SCHERING CORPORATION
发明人： DOLL, Ronald, J. , MALLAMS, Alan, K. , AFONSO, Adriano , RANE, Dinanath, F. , NJOROGE, F., George , ROSSMAN, Randall, R.
CPC分类号： C07D401/12 , C07D471/04
摘要： Novel compounds of Formula (1.0) are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
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5.发明公开TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环衍生物如适用G-蛋白抑制剂和增生性疾病的治疗
公开(公告)号：EP0819121A1
公开(公告)日：1998-01-21
申请号：EP96912469.0
申请日：1996-04-03
发明人： AFONSO, Adriano , BALDWIN, John, J. , DOLL, Ronald, J. , LI, Ge , MALLAMS, Alan, K. , NJOROGE, F., George , RANE, Dinanath, F. , READER, John, C. , ROSSMAN, Randall, R.
CPC分类号： C07D401/04 , C07D221/16 , C07D401/12 , C07D491/04
摘要： Novel compounds of Formula (1.0) are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
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6.发明公开TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE 失效三环CONNECTIONS适合...抑制蛋白质的法尼基转移
公开(公告)号：EP0819120A1
公开(公告)日：1998-01-21
申请号：EP96911442.0
申请日：1996-04-03
申请人： SCHERING CORPORATION
发明人： DOLL, Ronald, J. , MALLAMS, Alan, K. , AFONSO, Adriano , RANE, Dinanath, F. , ROSSMAN, Randall, R. , NJOROGE, F., George
CPC分类号： C07D401/12 , C07D211/32 , C07D221/16 , C07D401/14 , C07D409/12 , C07D491/04
摘要： Novel compounds of Formula (1.0) are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of Formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
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7.发明公开TYLOSIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND NOVEL PROCESSES INVOLVING TYLOSIN DERIVATIVES 失效TYLOSINABKÖMMLINGE及其制备和使用了新工艺。
公开(公告)号：EP0263834A1
公开(公告)日：1988-04-20
申请号：EP87900538.0
申请日：1986-12-19
申请人： SCHERING CORPORATION
IPC分类号： C07H17
CPC分类号： C07H17/08 , Y02P20/582
摘要： Nouveaux composés de di- et tri- O-acétyle-23-O-démycinosyle-4''-O-iso-valeryltylosine et leurs sels pharmaceutiquement acceptable, présentant une activité anti-bactérienne améliorée tout en assurant des niveaux sanguins plus élevés que d'autres composés dérivés de la tylosine. Ces composés présentent la formule structurale (I) où R est acétyle ou hydrogène et Z est par exemple O ou (II). Sont également décrits des procédés de désacylation sélective des positions 2' et 4'' de 3, 2', 4'', 4'''-tetra-O-acyltylosine ou de 2', 4'', 4'''-tri-O-acyltylosine et d'acylation sélective de 2', 4''-di-O-acyltylosine et de 2', 4'', 4'''-tri-O-acyltylosine.
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