利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.012 秒)

    Pertussis toxin mutants, bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines
    1.
    发明公开
    Pertussis toxin mutants, bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines 失效
    百日咳毒素突变体，同样的生产百日咳博德特氏菌及其作为抗百日咳疫苗的使用。

    公开(公告)号：EP0396964A1

    公开(公告)日：1990-11-14

    申请号：EP90107892.3

    申请日：1990-04-25

    申请人： SCLAVO S.p.A.

    发明人： Pizza, Mariagrazia ,  Covacci, Antonello ,  Rappuoli, Rino ,  Nencioni, Luciano

    IPC分类号： A61K39/10 ,  C12N15/31

    CPC分类号： C07K14/235 ,  A61K39/00 ,  A61K39/099

    摘要： New pertussis toxin (PT) mutants are described being immunologically active and having reduced or no toxicity, characterized in that at least one of the aminoacid residues Glu129, Asp11, Trp26, Arg9, Phe50, Asp1, Arg13, Tyr130, Gly86, Ile88, Tyr89, Tyr8, Gly 44, Thr53 and Gly80 of subunit's 1 aminoacid sequence is deleted and substituted by a different aminoacid residue selected in the group of natural aminoacids; Bordetella strains capable of providing and secreting said PT mutants and means and methods for obtaining them are also described.
    The Bordetella strains and the PT mutants produced by them are particularly suitable for the preparation of effective cellular and acellular antipertussis vaccines.

    摘要翻译： 新百日咳毒素（PT）的突变体被描述为免疫活性和具有降低的或没有毒性，在其特点做的氨基酸残基Glu129，Asp11，Trp26，Arg9，Phe50，ASP1，Arg13，Tyr130，Gly86，Ile88，Tyr89的至少一个 ，酪氨酸8，甘氨酸44，Thr53和亚单位的1个氨基酸序列的Gly80被删除，并且由组天然氨基酸中选择的不同氨基酸残基substituiertem; 博代氏杆菌菌株能够提供和分泌。所述PT突变体和手段和方法用于获得它们被这样描述的。 博德特氏菌菌株和由它们产生的PT突变体特别适合于有效的细胞和非细胞疫苗antipertussis的制备。

    A protective immunodominant epitope included in the S1 subunit of pertussis toxin
    3.
    发明公开
    A protective immunodominant epitope included in the S1 subunit of pertussis toxin 失效
    Schützendes独立主义者在S1-Untereinheit von Pertussistoxin中的Epitop。

    公开(公告)号：EP0320866A2

    公开(公告)日：1989-06-21

    申请号：EP88120779.9

    申请日：1988-12-13

    申请人： SCLAVO S.p.A.

    发明人： Bartoloni, Antonella ,  Pizza, Mariagrazia ,  Rappuoli, Rino

    IPC分类号： C07K13/00 ,  C12N15/00 ,  A61K39/10

    CPC分类号： C07K14/235 ,  A61K39/00

    摘要： There are described a protective immunodominant epitope of pertussis toxin which is included in the S1 subunit, and synthetic peptides with an aminoacid sequence similar to that of the epitope or to regions thereof which show an immunochemical reactivity with anti-PT protective monoclonal antibodies equivalent to that of the protein itself. Ihe peptides are particularly useful for the preparation of an antipertussis vaccine.

    摘要翻译： 描述了包含在S1亚基中的百日咳毒素的保护性免疫优势表位，以及具有与表位或其表位与抗PT保护性单克隆抗体相当的免疫化学反应性的氨基酸序列的氨基酸序列的合成肽 的蛋白质本身。 肽类特别可用于制备抗百日咳疫苗。

    Bordetella pertussis toxin with altered toxicity
    4.
    发明公开
    Bordetella pertussis toxin with altered toxicity 无效
    百日咳博德特氏菌毒素试剂盒Toxizität。

    公开(公告)号：EP0322533A1

    公开(公告)日：1989-07-05

    申请号：EP88117742.2

    申请日：1988-10-25

    申请人： SCLAVO S.p.A.

    发明人： Pizza, Mariagrazia ,  Rappuoli, Rino ,  Bartoloni, Antonella

    IPC分类号： C12N15/31 ,  A61K39/10

    CPC分类号： C07K14/235 ,  A61K39/00

    摘要： Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganismtransformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.

    摘要翻译： 无毒性或降低毒性的免疫活性多肽可用于制备抗百日咳疫苗。 用于制备所述多肽的方法，该方法包括：在合适的培养基中培养用包含编码至少一种所述多肽的基因的杂交质粒转化的微生物，并从细胞或培养基中回收所需的多肽。